Abstract: The comorbidity of diabetes and depression is relatively common in clinical practice,with a significant bidirectional association between the two conditions.. This comorbid state not only increases the disease burden and treatment complexity but also severely impacts patients' quality of life and long-term prognosis. The shared pathophysiological mechanisms of diabetes and depression may involve neuroendocrine dysregulation，chronic inflammation，and unhealthy lifestyle factors. Currently，clinical management faces several major challenges：insufficient awareness and recognition of the comorbidity among healthcare providers often leads to underdiagnosis or misdiagnosis of depression；lack of effective interdisciplinary collaboration hampers the implementation of integrated care；and the absence of specific diagnostic and treatment guidelines both domestically and internationally results in a lack of standardized clinical practice. To address these issues，the Psychosomatic Endocrinology Collaboration Group of the Psychosomatic Medicine Branch of the Chinese Medical Association，in collaboration with experts from endocrinology and metabolism，psychiatry，neurology，psychology，psychosomatic medicine，and traditional Chinese medicine，has developed the first Chinese Expert Consensus on the Diagnosis and Treatment of Diabetes Comorbid with Depression. This consensus systematically elaborates on the clinical features，pathophysiological mechanisms，assessment tools，and intervention strategies for the comorbidity，underscores the importance of multidisciplinary collaboration，proposes a standardized screening and diagnostic pathway，and provides specific recommendations for collaborative care. The release of this consensus aims to offer scientific and practical clinical guidance，improve the recognition and management of this comorbidity，and ultimately enhance overall patient care and long-term outcomes.

Key words: Diabetes mellitus, Depression, Comorbid, Diagnosis, Treatment, Expert consensus, Guidebook

摘要： 糖尿病与抑郁共病现象在临床中较为常见，二者之间存在显著的双向关系。这种共病状态不仅加重疾病负担，增加治疗复杂性，还显著影响患者的生活质量和长期预后。糖尿病与抑郁的共同病理机制可能涉及神经内分泌调节异常、慢性炎症反应及不良生活方式等多种因素。目前临床面临的主要挑战包括：医务人员对该共病的认识不足，导致抑郁症状常被忽视或漏诊；学科之间缺乏有效协作，限制了综合管理的实施；且国内外均缺乏专门针对该共病的诊疗指南，导致临床实践中缺乏统一标准。为此，由中华医学会心身医学分会心身内分泌协作学组牵头，联合内分泌代谢、精神医学、神经科、心理学、心身医学及中医学等多领域专家，首次制定了《糖尿病共患抑郁诊疗中国专家共识》。该共识系统阐述了糖尿病共患抑郁的临床特点、病理机制、评估工具及干预策略，明确强调多学科协作管理的重要性，提出了标准化的筛查与诊断路径，并给出了协作治疗的具体建议。共识的发布将为临床医生提供科学、可操作的诊疗指导，有助于提高共病的识别率与干预效率，促进糖尿病患者整体健康管理和预后改善。

关键词: 糖尿病, 抑郁, 共病, 诊断, 治疗, 共识, 指南