Cancer-related fatigue (CRF) is a painful, persistent, subjective, physical, emotional or cognitive feeling of fatigue caused by multiple factors related to cancer or cancer treatment, which does not match the amount of recent activity and seriously affects the quality of life of tumor patients. However, there are no approved Western medicine indications specifically for CRF, and treatment recommendations are mostly symptomatic and supportive. In contrast, traditional Chinese medicine (TCM) has demonstrated better clinical efficacy through syndrome differentiation and treatment. The "Clinical Practice Guideline for the Cancer-related Fatigue with Integrated Traditional Chinese and Western Medicine" still remains a blank slate. To better guide the clinical practice of integrated traditional Chinese and Western medicine in the management of CRF, the guideline working group, in collaboration with domestic experts in the field of oncology, conducted discussions based on evidence-based medicine. Ultimately, the "Clinical Practice Guideline for the Integrated Traditional Chinese and Western Medicine Diagnosis and Treatment of Cancer-related Fatigue" was formulated. This guideline introduces the epidemiological characteristics and pathogenesis of CRF, elaborates on the diagnostic criteria and evaluation methods from both traditional Chinese and Western medicine perspectives, and provides a detailed discussion of the integrated traditional Chinese and Western medicine treatment strategies. These strategies include TCM treatment, external TCM therapies, Western medicine treatment, psychological therapy, exercise, and dietary management. And the guideline offers recommendations for post-treatment assessment and preventive care to guide clinical treatment and improve patients' quality of life, with the aim of more formally, comprehensively, and integratively guiding and regulating the clinical diagnosis and treatment of CRF.

癌因性疲乏（CRF）是由癌症或癌症治疗相关的多种因素引起的一种痛苦的、持续的、主观的、有关躯体、情感或认知方面的疲乏感或疲惫感，且与近期的活动量不相符，严重影响肿瘤患者的生活质量。目前针对CRF西药无适应证用药推荐，多为对症支持治疗，而中医药通过辨证治疗有较好的临床疗效。有关CRF中西医结合的诊治指南尚为空白，为更好地指导中西医结合诊治CRF的临床实践，本指南工作组同国内部分肿瘤领域专家，结合循证证据进行讨论，最终形成《癌因性疲乏中西医结合诊治指南》，介绍了CRF的流行病学特点、病因病机，阐述了中西医诊断标准和评估方法，详细论述了中西医结合治疗策略，包括中药治疗、中医外治法、西药治疗、心理疗法、运动、饮食管理等，并对治疗后评估和预防调护给出建议，为临床治疗提供指导，提升患者生活质量，以期更加正规、全面、综合地指导和规范CRF的临床诊治。