Chinese General Practice ›› 2023, Vol. 26 ›› Issue (21): 2639-2646.DOI: 10.12114/j.issn.1007-9572.2023.0062
• Original Research • Previous Articles Next Articles
Received:
2023-02-05
Revised:
2023-03-23
Published:
2023-07-20
Online:
2023-03-30
Contact:
SONG Guangyao
通讯作者:
宋光耀
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2023.0062
组别 | 只数 | 体质量(g) | 肝指数(%) | 肝脏TG(mmol/g) | GIR (mg·kg-1·min-1) |
---|---|---|---|---|---|
ND组 | 6 | 305.7±24.6 | 2.44±0.25 | 0.71±0.07 | 27.36±2.16 |
造模组 | 6 | 328.8±35.1a | 2.58±0.30 | 1.55±0.15a | 18.17±2.62 |
t值 | -2.242 | -2.524 | -12.536 | 5.409 | |
P值 | 0.041 | 0.030 | <0.001 | 0.020 |
Table 1 Comparison of relevant indicators of rats between ND group and model group after 8-week high-fructose feeding
组别 | 只数 | 体质量(g) | 肝指数(%) | 肝脏TG(mmol/g) | GIR (mg·kg-1·min-1) |
---|---|---|---|---|---|
ND组 | 6 | 305.7±24.6 | 2.44±0.25 | 0.71±0.07 | 27.36±2.16 |
造模组 | 6 | 328.8±35.1a | 2.58±0.30 | 1.55±0.15a | 18.17±2.62 |
t值 | -2.242 | -2.524 | -12.536 | 5.409 | |
P值 | 0.041 | 0.030 | <0.001 | 0.020 |
组别 | 只数 | 体质量(g) | 肝指数(%) | TG (mmol/L) | TC (mmol/L) | FFA (mmol/L) | ALT (U/L) | AST (U/L) | FBG (mmol/L) | FINS (mU/L) | AUCglu (mmol/L×h) | GIR (mg·kg-1·min-1) |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ND组 | 6 | 353.8±35.4 | 2.46±0.26 | 0.51±0.13 | 1.41±0.35 | 0.71±0.20 | 34.43±4.86 | 125.88±19.46 | 5.89±1.03 | 0.90±0.12 | 13.48±1.85 | 26.75±1.63 |
HFD亚组 | 6 | 405.8±38.3a | 2.96±0.15a | 0.84±0.22a | 1.64±0.22 | 0.95±0.15a | 46.29±8.64a | 129.43±30.14 | 7.13±0.49a | 1.76±0.13a | 21.25±2.77a | 15.36±1.22a |
HFD+Ex亚组 | 6 | 329.2±28.9b | 2.60±0.15b | 0.67±0.17 | 1.46±0.10 | 0.80±0.15b | 38.00±8.50b | 115.43±34.96 | 5.91±0.92b | 1.01±0.10b | 15.02±2.50b | 20.88±1.29b |
F值 | 4.511 | 3.869 | 7.128 | 1.447 | 4.519 | 5.536 | 0.939 | 4.968 | 8.799 | 10.411 | 7.479 | |
P值 | 0.025 | 0.041 | 0.005 | 0.260 | 0.025 | 0.013 | 0.410 | 0.018 | 0.001 | 0.011 | 0.005 |
Table 2 Comparison of relevant indicators of rats in three groups after 4-week drug intervention
组别 | 只数 | 体质量(g) | 肝指数(%) | TG (mmol/L) | TC (mmol/L) | FFA (mmol/L) | ALT (U/L) | AST (U/L) | FBG (mmol/L) | FINS (mU/L) | AUCglu (mmol/L×h) | GIR (mg·kg-1·min-1) |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ND组 | 6 | 353.8±35.4 | 2.46±0.26 | 0.51±0.13 | 1.41±0.35 | 0.71±0.20 | 34.43±4.86 | 125.88±19.46 | 5.89±1.03 | 0.90±0.12 | 13.48±1.85 | 26.75±1.63 |
HFD亚组 | 6 | 405.8±38.3a | 2.96±0.15a | 0.84±0.22a | 1.64±0.22 | 0.95±0.15a | 46.29±8.64a | 129.43±30.14 | 7.13±0.49a | 1.76±0.13a | 21.25±2.77a | 15.36±1.22a |
HFD+Ex亚组 | 6 | 329.2±28.9b | 2.60±0.15b | 0.67±0.17 | 1.46±0.10 | 0.80±0.15b | 38.00±8.50b | 115.43±34.96 | 5.91±0.92b | 1.01±0.10b | 15.02±2.50b | 20.88±1.29b |
F值 | 4.511 | 3.869 | 7.128 | 1.447 | 4.519 | 5.536 | 0.939 | 4.968 | 8.799 | 10.411 | 7.479 | |
P值 | 0.025 | 0.041 | 0.005 | 0.260 | 0.025 | 0.013 | 0.410 | 0.018 | 0.001 | 0.011 | 0.005 |
组别 | 只数 | SREBP-1 | FAS | SCD-1 | ACC |
---|---|---|---|---|---|
ND组 | 6 | 0.50±0.05 | 0.49±0.07 | 0.48±0.06 | 0.58±0.11 |
HFD亚组 | 6 | 0.91±0.12a | 0.91±0.08a | 0.88±0.06a | 0.93±0.07a |
HFD+Ex亚组 | 6 | 0.64±0.07b | 0.54±0.04b | 0.56±0.08b | 0.56±0.04b |
F值 | 24.426 | 30.948 | 37.117 | 21.583 | |
P值 | 0.001 | 0.001 | <0.001 | 0.002 |
Table 3 Comparison of SREBP-1、FAS、SCD-1 and ACC protein expression in liver of rats among three groups
组别 | 只数 | SREBP-1 | FAS | SCD-1 | ACC |
---|---|---|---|---|---|
ND组 | 6 | 0.50±0.05 | 0.49±0.07 | 0.48±0.06 | 0.58±0.11 |
HFD亚组 | 6 | 0.91±0.12a | 0.91±0.08a | 0.88±0.06a | 0.93±0.07a |
HFD+Ex亚组 | 6 | 0.64±0.07b | 0.54±0.04b | 0.56±0.08b | 0.56±0.04b |
F值 | 24.426 | 30.948 | 37.117 | 21.583 | |
P值 | 0.001 | 0.001 | <0.001 | 0.002 |
组别 | 只数 | β-catenin总蛋白 | β-catenin核内蛋白 |
---|---|---|---|
ND组 | 6 | 0.82±0.05 | 0.85±0.07 |
HFD亚组 | 6 | 0.43±0.06a | 0.58±0.08a |
HFD+Ex亚组 | 6 | 0.67±0.08b | 0.94±0.10b |
F值 | 12.373 | 32.03 | |
P值 | 0.007 | 0.001 |
Table 4 Comparison of β-catenin protein expression in liver of rats among three groups
组别 | 只数 | β-catenin总蛋白 | β-catenin核内蛋白 |
---|---|---|---|
ND组 | 6 | 0.82±0.05 | 0.85±0.07 |
HFD亚组 | 6 | 0.43±0.06a | 0.58±0.08a |
HFD+Ex亚组 | 6 | 0.67±0.08b | 0.94±0.10b |
F值 | 12.373 | 32.03 | |
P值 | 0.007 | 0.001 |
组别 | 细胞数 | β-catenin总蛋白 | β-catenin核内蛋白 | TG (μmol/mg) |
---|---|---|---|---|
Con组 | 6 | 0.52±0.03 | 0.54±0.07 | 26.36±2.71 |
HF组 | 6 | 0.40±0.02a | 0.41±0.06a | 44.94±3.79a |
HF+Ex4组 | 6 | 0.63±0.07b | 0.58±0.05b | 33.06±5.82b |
HF+Ex4+Si-control组 | 6 | 0.56±0.06b | 0.62±0.10b | 34.29±5.17b |
HF+Ex4+Si-β-catenin组 | 6 | 0.17±0.02ac | 0.18±0.01ac | 40.44±5.15ac |
F值 | 20.467 | 11.305 | 9.369 | |
P值 | <0.001 | 0.001 | 0.01 |
Table 5 Comparison of β-catenin protein expression and TG levels of HepG2 cells among five groups
组别 | 细胞数 | β-catenin总蛋白 | β-catenin核内蛋白 | TG (μmol/mg) |
---|---|---|---|---|
Con组 | 6 | 0.52±0.03 | 0.54±0.07 | 26.36±2.71 |
HF组 | 6 | 0.40±0.02a | 0.41±0.06a | 44.94±3.79a |
HF+Ex4组 | 6 | 0.63±0.07b | 0.58±0.05b | 33.06±5.82b |
HF+Ex4+Si-control组 | 6 | 0.56±0.06b | 0.62±0.10b | 34.29±5.17b |
HF+Ex4+Si-β-catenin组 | 6 | 0.17±0.02ac | 0.18±0.01ac | 40.44±5.15ac |
F值 | 20.467 | 11.305 | 9.369 | |
P值 | <0.001 | 0.001 | 0.01 |
组别 | 细胞数 | SREBP-1 | ACC | FAS | SCD-1 |
---|---|---|---|---|---|
Con组 | 6 | 0.38±0.05 | 0.46±0.04 | 0.45±0.05 | 0.56±0.06 |
HF组 | 6 | 0.59±0.03a | 0.62±0.05a | 0.66±0.04a | 0.88±0.08a |
HF+Ex4组 | 6 | 0.47±0.04b | 0.48±0.05b | 0.50±0.05b | 0.65±0.05b |
HF+Ex4+Si-control组 | 6 | 0.47±0.07b | 0.49±0.05b | 0.49±0.06b | 0.63±0.03b |
HF+Ex4+Si-β-catenin组 | 6 | 0.58±0.08ac | 0.60±0.10ac | 0.61±0.04ac | 0.83±0.07ac |
F值 | 7.019 | 3.903 | 8.956 | 14.683 | |
P值 | 0.006 | 0.037 | 0.002 | <0.001 |
Table 6 Comparison of SREBP-1、ACC、FAS and SCD-1 protein expression of HepG2 cells among five groups
组别 | 细胞数 | SREBP-1 | ACC | FAS | SCD-1 |
---|---|---|---|---|---|
Con组 | 6 | 0.38±0.05 | 0.46±0.04 | 0.45±0.05 | 0.56±0.06 |
HF组 | 6 | 0.59±0.03a | 0.62±0.05a | 0.66±0.04a | 0.88±0.08a |
HF+Ex4组 | 6 | 0.47±0.04b | 0.48±0.05b | 0.50±0.05b | 0.65±0.05b |
HF+Ex4+Si-control组 | 6 | 0.47±0.07b | 0.49±0.05b | 0.49±0.06b | 0.63±0.03b |
HF+Ex4+Si-β-catenin组 | 6 | 0.58±0.08ac | 0.60±0.10ac | 0.61±0.04ac | 0.83±0.07ac |
F值 | 7.019 | 3.903 | 8.956 | 14.683 | |
P值 | 0.006 | 0.037 | 0.002 | <0.001 |
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