Chinese General Practice ›› 2023, Vol. 26 ›› Issue (14): 1753-1757.DOI: 10.12114/j.issn.1007-9572.2022.0667
• Original Research • Previous Articles Next Articles
Received:
2022-09-10
Revised:
2022-11-03
Published:
2023-05-15
Online:
2022-11-24
Contact:
SUN Liping
通讯作者:
孙丽萍
作者简介:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0667
项目 | 未继发EPVS组(n=152) | 继发EPVS组(n=114) | 检验统计量值 | P值 |
---|---|---|---|---|
年龄( | 65.8±11.2 | 70.4±13.9 | 3.512a | 0.001 |
性别(男/女) | 109/43 | 69/45 | 3.681b | 0.055 |
吸烟史〔n(%)〕 | 67(44.1) | 53(46.5) | 0.153b | 0.696 |
饮酒史〔n(%)〕 | 39(25.7) | 24(21.0) | 0.764b | 0.382 |
高血压史〔n(%)〕 | 77(50.7) | 80(70.2) | 10.463b | 0.001 |
糖尿病史〔n(%)〕 | 73(47.4) | 44(38.6) | 2.351b | 0.125 |
心房颤动史〔n(%)〕 | 10(6.6) | 5(4.4) | 0.589b | 0.443 |
冠心病史〔n(%)〕 | 14(9.2) | 14(12.3) | 0.652b | 0.419 |
颈内动脉狭窄史〔n(%)〕 | 16(10.5) | 8(7.0) | 0.708b | 0.400 |
SBP( | 147±24 | 146±22 | 0.468a | 0.641 |
DBP( | 84±10 | 85±11 | 0.569a | 0.570 |
TC( | 4.01±0.86 | 3.90±0.74 | 1.119a | 0.265 |
TG( | 2.20±0.50 | 2.33±0.57 | 1.939a | 0.054 |
FBG( | 6.03±1.29 | 5.78±1.16 | 1.658a | 0.099 |
HDL-C( | 2.31±0.42 | 2.26±0.37 | 1.029a | 0.305 |
LDL-C( | 1.14±0.40 | 1.10±0.36 | 0.855a | 0.394 |
SUA( | 322.09±81.70 | 329.46±83.27 | 0.720a | 0.472 |
Scr( | 70.71±7.55 | 69.48±7.16 | 1.359a | 0.176 |
Hcy( | 15.93±4.21 | 16.22±4.47 | 0.592a | 0.537 |
48 h NIHSS评分( | 2.50±0.27 | 2.48±0.23 | 0.651a | 0.516 |
7 d NIHSS评分〔M(P25,P75),分〕 | 0(0,1.00) | 0(0,1.00) | 0.732c | 0.615 |
眼底动脉硬化程度〔M(P25,P75),度〕 | 1.0(1.0,2.0) | 0(0,1.0) | 7.321c | 0.001 |
眼底血管弯曲度〔M(P25,P75),度〕 | 1.0(1.0,1.0) | 1.0(1.0,1.0) | 1.385c | 0.832 |
视网膜中央动脉直径( | 115.70±14.90 | 104.89±11.35 | 6.717a | <0.001 |
视网膜动静脉比值( | 0.61±0.12 | 0.50±0.09 | 8.544a | <0.001 |
血管瘤〔n(%)〕 | 12(7.9) | 35(30.7) | 23.293b | <0.001 |
视网膜动静脉交叉征〔n(%)〕 | 18(11.8) | 107(93.9) | 175.920b | <0.001 |
Table 1 Comparison of clinical data between mild acute cerebral infarction patients with and without secondary enlarged perivascular spaces
项目 | 未继发EPVS组(n=152) | 继发EPVS组(n=114) | 检验统计量值 | P值 |
---|---|---|---|---|
年龄( | 65.8±11.2 | 70.4±13.9 | 3.512a | 0.001 |
性别(男/女) | 109/43 | 69/45 | 3.681b | 0.055 |
吸烟史〔n(%)〕 | 67(44.1) | 53(46.5) | 0.153b | 0.696 |
饮酒史〔n(%)〕 | 39(25.7) | 24(21.0) | 0.764b | 0.382 |
高血压史〔n(%)〕 | 77(50.7) | 80(70.2) | 10.463b | 0.001 |
糖尿病史〔n(%)〕 | 73(47.4) | 44(38.6) | 2.351b | 0.125 |
心房颤动史〔n(%)〕 | 10(6.6) | 5(4.4) | 0.589b | 0.443 |
冠心病史〔n(%)〕 | 14(9.2) | 14(12.3) | 0.652b | 0.419 |
颈内动脉狭窄史〔n(%)〕 | 16(10.5) | 8(7.0) | 0.708b | 0.400 |
SBP( | 147±24 | 146±22 | 0.468a | 0.641 |
DBP( | 84±10 | 85±11 | 0.569a | 0.570 |
TC( | 4.01±0.86 | 3.90±0.74 | 1.119a | 0.265 |
TG( | 2.20±0.50 | 2.33±0.57 | 1.939a | 0.054 |
FBG( | 6.03±1.29 | 5.78±1.16 | 1.658a | 0.099 |
HDL-C( | 2.31±0.42 | 2.26±0.37 | 1.029a | 0.305 |
LDL-C( | 1.14±0.40 | 1.10±0.36 | 0.855a | 0.394 |
SUA( | 322.09±81.70 | 329.46±83.27 | 0.720a | 0.472 |
Scr( | 70.71±7.55 | 69.48±7.16 | 1.359a | 0.176 |
Hcy( | 15.93±4.21 | 16.22±4.47 | 0.592a | 0.537 |
48 h NIHSS评分( | 2.50±0.27 | 2.48±0.23 | 0.651a | 0.516 |
7 d NIHSS评分〔M(P25,P75),分〕 | 0(0,1.00) | 0(0,1.00) | 0.732c | 0.615 |
眼底动脉硬化程度〔M(P25,P75),度〕 | 1.0(1.0,2.0) | 0(0,1.0) | 7.321c | 0.001 |
眼底血管弯曲度〔M(P25,P75),度〕 | 1.0(1.0,1.0) | 1.0(1.0,1.0) | 1.385c | 0.832 |
视网膜中央动脉直径( | 115.70±14.90 | 104.89±11.35 | 6.717a | <0.001 |
视网膜动静脉比值( | 0.61±0.12 | 0.50±0.09 | 8.544a | <0.001 |
血管瘤〔n(%)〕 | 12(7.9) | 35(30.7) | 23.293b | <0.001 |
视网膜动静脉交叉征〔n(%)〕 | 18(11.8) | 107(93.9) | 175.920b | <0.001 |
变量 | B | SE | Wald χ2值 | P值 | OR值 | 95%CI |
---|---|---|---|---|---|---|
年龄 | 0.038 | 0.031 | 1.503 | 0.220 | 1.039 | (0.977,1.104) |
高血压史 | 1.140 | 0.370 | 9.493 | 0.002 | 3.127 | (1.514,6.457) |
眼底动脉硬化程度 | 1.124 | 0.151 | 55.409 | <0.001 | 3.077 | (2.289,4.137) |
视网膜中央动脉直径 | 0.493 | 0.397 | 1.542 | 0.214 | 1.637 | (0.752,3.565) |
视网膜动静脉比值 | -1.579 | 1.258 | 1.575 | 0.209 | 0.206 | (0.018,2.427) |
血管瘤 | 0.973 | 0.725 | 1.801 | 0.180 | 2.646 | (0.639,10.957) |
视网膜动静脉交叉征 | 0.066 | 0.062 | 1.133 | 0.287 | 1.068 | (0.946,1.206) |
Table 2 Multivariate Logistic regression analysis of factors associated with the severity of enlarged perivascular spaces secondary to mild acute cerebral infarction
变量 | B | SE | Wald χ2值 | P值 | OR值 | 95%CI |
---|---|---|---|---|---|---|
年龄 | 0.038 | 0.031 | 1.503 | 0.220 | 1.039 | (0.977,1.104) |
高血压史 | 1.140 | 0.370 | 9.493 | 0.002 | 3.127 | (1.514,6.457) |
眼底动脉硬化程度 | 1.124 | 0.151 | 55.409 | <0.001 | 3.077 | (2.289,4.137) |
视网膜中央动脉直径 | 0.493 | 0.397 | 1.542 | 0.214 | 1.637 | (0.752,3.565) |
视网膜动静脉比值 | -1.579 | 1.258 | 1.575 | 0.209 | 0.206 | (0.018,2.427) |
血管瘤 | 0.973 | 0.725 | 1.801 | 0.180 | 2.646 | (0.639,10.957) |
视网膜动静脉交叉征 | 0.066 | 0.062 | 1.133 | 0.287 | 1.068 | (0.946,1.206) |
指标 | rs值 | P值 |
---|---|---|
眼底动脉硬化程度 | 0.751 | <0.001 |
视网膜中央动脉直径 | -0.342 | <0.001 |
视网膜动静脉比值 | -0.463 | 0.012 |
血管瘤 | 0.644 | <0.001 |
视网膜动静脉交叉征 | 0.589 | <0.001 |
Table 3 Spearman's rank correlation analysis of the severity of enlarged perivascular spaces with fundus vascular lesions
指标 | rs值 | P值 |
---|---|---|
眼底动脉硬化程度 | 0.751 | <0.001 |
视网膜中央动脉直径 | -0.342 | <0.001 |
视网膜动静脉比值 | -0.463 | 0.012 |
血管瘤 | 0.644 | <0.001 |
视网膜动静脉交叉征 | 0.589 | <0.001 |
指标 | B | 95%CI | SE | t值 | P值 |
---|---|---|---|---|---|
眼底动脉硬化程度 | 0.586 | (0.345,0.827) | 0.241 | 2.432 | 0.016 |
视网膜中央动脉直径 | -0.321 | (-0.524,-0.118) | 0.203 | -1.581 | 0.115 |
视网膜动静脉比值 | -3.974 | (-5.548,-2.400) | 1.574 | -2.525 | 0.012 |
血管瘤 | 1.558 | (0.351,2.765) | 1.207 | 1.291 | 0.198 |
视网膜动静脉交叉征 | 0.472 | (0.291,0.653) | 0.181 | 2.608 | 0.010 |
Table 4 Multivariate linear regression analysis of the number of enlarged perivascular spaces with fundus vascular lesions
指标 | B | 95%CI | SE | t值 | P值 |
---|---|---|---|---|---|
眼底动脉硬化程度 | 0.586 | (0.345,0.827) | 0.241 | 2.432 | 0.016 |
视网膜中央动脉直径 | -0.321 | (-0.524,-0.118) | 0.203 | -1.581 | 0.115 |
视网膜动静脉比值 | -3.974 | (-5.548,-2.400) | 1.574 | -2.525 | 0.012 |
血管瘤 | 1.558 | (0.351,2.765) | 1.207 | 1.291 | 0.198 |
视网膜动静脉交叉征 | 0.472 | (0.291,0.653) | 0.181 | 2.608 | 0.010 |
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