Chinese General Practice ›› 2023, Vol. 26 ›› Issue (17): 2176-2182.DOI: 10.12114/j.issn.1007-9572.2022.0609
Special Issue: 神经退行性病变最新文章合集; 阿尔茨海默病最新文章合集
• Review & Perspectives • Previous Articles
Received:
2022-06-26
Revised:
2022-10-08
Published:
2023-06-15
Online:
2022-10-13
Contact:
BAI Yanjie
通讯作者:
白艳杰
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0609
第一作者 | 发表年份(年) | 研究类型 | 主要结果 |
---|---|---|---|
MATSUYAMA[ | 2020 | 动物实验 | NLRP3炎症小体、IL-18、IL-1β均上调 |
LI[ | 2022 | 细胞实验 | NLRP3、ASC、caspase-1、IL-1β、IL-18均上调 |
吴金波[ | 2021 | 临床研究 | NLRP3 mRNA上调 |
李国丽[ | 2022 | 临床研究 | NLRP3、IL-1β、IL-18均上调 |
赵凤华[ | 2021 | 临床研究 | NLRP3、ASC、caspase-1、IL-1β均上调 |
Table 1 Studies on the increased expression of NLRP3 inflammasome in PSCI
第一作者 | 发表年份(年) | 研究类型 | 主要结果 |
---|---|---|---|
MATSUYAMA[ | 2020 | 动物实验 | NLRP3炎症小体、IL-18、IL-1β均上调 |
LI[ | 2022 | 细胞实验 | NLRP3、ASC、caspase-1、IL-1β、IL-18均上调 |
吴金波[ | 2021 | 临床研究 | NLRP3 mRNA上调 |
李国丽[ | 2022 | 临床研究 | NLRP3、IL-1β、IL-18均上调 |
赵凤华[ | 2021 | 临床研究 | NLRP3、ASC、caspase-1、IL-1β均上调 |
第一作者 | 发表年份(年) | 研究类型 | 干预方式 | 治疗作用机制 |
---|---|---|---|---|
LI[ | 2020 | 动物实验 | MCC950 | 阻断NLRP3寡聚化和形成,减少小胶质细胞数量,增加神经元数量,促进海马神经发生 |
WANG[ | 2017 | 动物实验 | DY-9836 | 抑制亚硝化应激和NLRP3信号传导 |
FENG[ | 2021 | 动物实验 | miR-138-5p | 与NLRP3特异性相互作用,改善神经炎症 |
ZHANG[ | 2021 | 动物+细胞实验 | 牡荆素 | 抑制NLRP3炎症小体介导的炎性反应 |
ZHANG[ | 2020 | 动物实验 | Kellerin | 抑制NLRP3炎症小体通路的激活,调节小胶质细胞的极化 |
LI[ | 2017 | 动物实验 | 黄芪甲苷 | 控制ROS的产生来抑制NLRP3炎症小体活化,降低海马中小胶质细胞的过度激活和炎性细胞因子的过度表达 |
LIU[ | 2020 | 动物实验 | 蛇床子素 | 改善海马神经元损伤,抑制小胶质细胞活化,并通过抑制NLRP3炎症小体活化减少海马中的Aβ沉积 |
BANG[ | 2019 | 动物实验 | 梅素 | 抑制神经胶质增生并减弱NLRP3和NF-κB的激活 |
SHI[ | 2021 | 网络药理学和分子对接 | 益智通脉汤 | 抑制NLRP3炎症小体、TNF信号通路和toll样受体信号通路 |
XIA[ | 2019 | 动物实验 | 小脑顶核电刺激 | 下调NLRP3、caspase-1、IL-1β、IL-18的表达,抑制自噬过程和炎性反应,从而减轻神经元的凋亡 |
DU[ | 2018 | 动物实验 | 针刺足三里和百会穴 | 减少海马神经元丢失和氧化应激,降低硫氧还蛋白相互作用蛋白、NLRP3、caspase-1和IL-1β的表达 |
ZHONG[ | 2022 | 动物实验 | 电针神庭和百会穴 | 上调线粒体自噬相关蛋白和抑制ROS诱导的NLRP3炎症小体活化发挥神经保护作用 |
Table 2 Studies on inhibition NLRP3 inflammasome to improve PSCI
第一作者 | 发表年份(年) | 研究类型 | 干预方式 | 治疗作用机制 |
---|---|---|---|---|
LI[ | 2020 | 动物实验 | MCC950 | 阻断NLRP3寡聚化和形成,减少小胶质细胞数量,增加神经元数量,促进海马神经发生 |
WANG[ | 2017 | 动物实验 | DY-9836 | 抑制亚硝化应激和NLRP3信号传导 |
FENG[ | 2021 | 动物实验 | miR-138-5p | 与NLRP3特异性相互作用,改善神经炎症 |
ZHANG[ | 2021 | 动物+细胞实验 | 牡荆素 | 抑制NLRP3炎症小体介导的炎性反应 |
ZHANG[ | 2020 | 动物实验 | Kellerin | 抑制NLRP3炎症小体通路的激活,调节小胶质细胞的极化 |
LI[ | 2017 | 动物实验 | 黄芪甲苷 | 控制ROS的产生来抑制NLRP3炎症小体活化,降低海马中小胶质细胞的过度激活和炎性细胞因子的过度表达 |
LIU[ | 2020 | 动物实验 | 蛇床子素 | 改善海马神经元损伤,抑制小胶质细胞活化,并通过抑制NLRP3炎症小体活化减少海马中的Aβ沉积 |
BANG[ | 2019 | 动物实验 | 梅素 | 抑制神经胶质增生并减弱NLRP3和NF-κB的激活 |
SHI[ | 2021 | 网络药理学和分子对接 | 益智通脉汤 | 抑制NLRP3炎症小体、TNF信号通路和toll样受体信号通路 |
XIA[ | 2019 | 动物实验 | 小脑顶核电刺激 | 下调NLRP3、caspase-1、IL-1β、IL-18的表达,抑制自噬过程和炎性反应,从而减轻神经元的凋亡 |
DU[ | 2018 | 动物实验 | 针刺足三里和百会穴 | 减少海马神经元丢失和氧化应激,降低硫氧还蛋白相互作用蛋白、NLRP3、caspase-1和IL-1β的表达 |
ZHONG[ | 2022 | 动物实验 | 电针神庭和百会穴 | 上调线粒体自噬相关蛋白和抑制ROS诱导的NLRP3炎症小体活化发挥神经保护作用 |
[1] |
董强,郭起浩,罗本燕,等. 卒中后认知障碍管理专家共识[J]. 中国卒中杂志,2017,12(6):519-531.
|
[2] |
|
[3] |
|
[4] |
|
[5] |
|
[6] |
|
[7] |
|
[8] |
|
[9] |
|
[10] |
|
[11] |
|
[12] |
|
[13] |
|
[14] |
|
[15] |
|
[16] |
|
[17] |
|
[18] |
|
[19] |
|
[20] |
|
[21] |
|
[22] |
|
[23] |
|
[24] |
|
[25] |
|
[26] |
|
[27] |
|
[28] |
|
[29] |
|
[30] |
李程飞,潘益凯,李曦,等. 线粒体相关内质网膜(MAMs)在心血管疾病中的研究进展[J]. 心脏杂志,2022,34(1):79-84.
|
[31] |
|
[32] |
|
[33] |
|
[34] |
|
[35] |
|
[36] |
|
[37] |
|
[38] |
|
[39] |
|
[40] |
|
[41] |
|
[42] |
|
[43] |
|
[44] |
|
[45] |
|
[46] |
吴金波,杨春兰,姚振兴,等. 血清sRAGE、25-羟维生素-D3、NLRP3 mRNA与高血压脑出血患者发生认知功能损害的关系[J]. 中国医师杂志,2021,23(10):1492-1495,1500.
|
[47] |
李国丽,许海霞,岑岚,等. NLRP3炎症小体的活化水平与急性缺血性脑卒中患者认知功能改变的关系[J]. 脑与神经疾病杂志,2022,30(2):67-71.
|
[48] |
赵凤华,李万春,阮世旺,等. NLRP3炎症小体的活化水平与急性缺血性脑卒中患者认知功能改变的关系[J]. 中华行为医学与脑科学杂志,2021,30(6):515-521. DOI:10.3760/cma.j.cn371468-20210105-00009.
|
[49] |
|
[50] |
|
[51] |
|
[52] |
|
[53] |
|
[54] |
|
[55] |
|
[56] |
|
[57] |
|
[58] |
|
[59] |
|
[60] |
|
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