Chinese General Practice ›› 2023, Vol. 26 ›› Issue (05): 576-582.DOI: 10.12114/j.issn.1007-9572.2022.0520
Special Issue: 心血管最新文章合集; 高血压最新文章合集
• Original Research • Previous Articles Next Articles
Received:
2022-04-11
Revised:
2022-08-12
Published:
2023-02-15
Online:
2022-09-30
Contact:
HE Fang
通讯作者:
何芳
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0520
基因 | 引物序列(5'—3') |
---|---|
GAPDH | F:GACATGCCGCCTGGAGAAAC |
R:AGCCCAGGATGCCCTTTAGT | |
VEGFA | F:CCCTGGCTTTACTGCTGTACC |
R:CTTCATGGGCTTTCTGCTCCC | |
CaSR | F:ACGAGCCTCAGAAGAATGCC |
R:TCCGCATCTGCACACTGTAG |
Table 1 Primer sequences for GAPDH,VEGFA and CaSR
基因 | 引物序列(5'—3') |
---|---|
GAPDH | F:GACATGCCGCCTGGAGAAAC |
R:AGCCCAGGATGCCCTTTAGT | |
VEGFA | F:CCCTGGCTTTACTGCTGTACC |
R:CTTCATGGGCTTTCTGCTCCC | |
CaSR | F:ACGAGCCTCAGAAGAATGCC |
R:TCCGCATCTGCACACTGTAG |
组别 | 只数 | SBP | DBP | MAP | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
干预0周 | 干预16周 | t配对值 | P值 | 干预0周 | 干预16周 | t配对值 | P值 | 干预0周 | 干预16周 | t配对值 | P值 | ||
WKY组 | 5 | 107±1 | 108±1 | 0.260 | 0.999 | 92±6 | 101±10 | 1.744 | 0.575 | 95±3 | 103±6 | 1.973 | 0.479 |
SHR组 | 5 | 116±1a | 170±6ab | 22.610 | <0.001 | 108±5a | 141±10ab | 5.610 | 0.002 | 111±3a | 150±9ab | 8.959 | <0.001 |
SHR+NPS2143组 | 5 | 116±4 | 184±1 | 25.280 | <0.001 | 109±2 | 169±6 | 9.332 | <0.001 | 112±1 | 174±4 | 12.950 | <0.001 |
F值 | 124.500 | 259.300 | 12.910 | 30.420 | 30.220 | 57.880 | |||||||
P值 | <0.001 | <0.001 | 0.007 | 0.010 | 0.004 | 0.004 |
Table 2 Comparison of blood pressure in three groups of rats at baseline and 16 weeks of intervention
组别 | 只数 | SBP | DBP | MAP | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
干预0周 | 干预16周 | t配对值 | P值 | 干预0周 | 干预16周 | t配对值 | P值 | 干预0周 | 干预16周 | t配对值 | P值 | ||
WKY组 | 5 | 107±1 | 108±1 | 0.260 | 0.999 | 92±6 | 101±10 | 1.744 | 0.575 | 95±3 | 103±6 | 1.973 | 0.479 |
SHR组 | 5 | 116±1a | 170±6ab | 22.610 | <0.001 | 108±5a | 141±10ab | 5.610 | 0.002 | 111±3a | 150±9ab | 8.959 | <0.001 |
SHR+NPS2143组 | 5 | 116±4 | 184±1 | 25.280 | <0.001 | 109±2 | 169±6 | 9.332 | <0.001 | 112±1 | 174±4 | 12.950 | <0.001 |
F值 | 124.500 | 259.300 | 12.910 | 30.420 | 30.220 | 57.880 | |||||||
P值 | <0.001 | <0.001 | 0.007 | 0.010 | 0.004 | 0.004 |
组别 | 只数 | HW/BW% | LVW/BW% | CVF | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
干预0周 | 干预16周 | t配对值 | P值 | 干预0周 | 干预16周 | t配对值 | P值 | 干预0周 | 干预16周 | t配对值 | P值 | ||
WKY组 | 5 | 0.320±0.006 | 0.340±0.006 | 2.909 | 0.094 | 0.230±0.010 | 0.240±0.003 | 1.401 | 0.644 | 3.06±0.52 | 3.06±0.04 | 0.001 | 0.999 |
SHR组 | 5 | 0.330±0.002 | 0.370±0.001ab | 6.898 | 0.001 | 0.220±0.011 | 0.280±0.008ab | 6.672 | <0.001 | 2.93±0.64 | 7.41±0.54ab | 3.834 | 0.032 |
SHR+NPS2143组 | 5 | 0.330±0.003 | 0.390±0.008 | 3.803 | 0.026 | 0.240±0.011 | 0.310±0.005 | 4.880 | 0.002 | 2.74±0.37 | 9.90±0.03 | 4.577 | 0.013 |
F值 | 3.610 | 2.235 | 1.065 | 58.590 | 0.097 | 122.600 | |||||||
P值 | 0.159 | 0.002 | 0.447 | <0.001 | 0.910 | 0.001 |
Table 3 Comparison of HW/BW%,LVW/BW%,and myocardial collagen volume fraction in three groups of rats at baseline and 16 weeks of intervention
组别 | 只数 | HW/BW% | LVW/BW% | CVF | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
干预0周 | 干预16周 | t配对值 | P值 | 干预0周 | 干预16周 | t配对值 | P值 | 干预0周 | 干预16周 | t配对值 | P值 | ||
WKY组 | 5 | 0.320±0.006 | 0.340±0.006 | 2.909 | 0.094 | 0.230±0.010 | 0.240±0.003 | 1.401 | 0.644 | 3.06±0.52 | 3.06±0.04 | 0.001 | 0.999 |
SHR组 | 5 | 0.330±0.002 | 0.370±0.001ab | 6.898 | 0.001 | 0.220±0.011 | 0.280±0.008ab | 6.672 | <0.001 | 2.93±0.64 | 7.41±0.54ab | 3.834 | 0.032 |
SHR+NPS2143组 | 5 | 0.330±0.003 | 0.390±0.008 | 3.803 | 0.026 | 0.240±0.011 | 0.310±0.005 | 4.880 | 0.002 | 2.74±0.37 | 9.90±0.03 | 4.577 | 0.013 |
F值 | 3.610 | 2.235 | 1.065 | 58.590 | 0.097 | 122.600 | |||||||
P值 | 0.159 | 0.002 | 0.447 | <0.001 | 0.910 | 0.001 |
组别 | 只数 | 视网膜总厚度 | 视网膜内丛状层厚度 | 视网膜内核层厚度 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
干预0周 | 干预16周 | t配对值 | P值 | 干预0周 | 干预16周 | t配对值 | P值 | 干预0周 | 干预16周 | t配对值 | P值 | ||
WKY组 | 5 | 56.08±4.69 | 95.01±1.36 | 14.430 | <0.001 | 12.59±1.99 | 22.23±1.69 | 4.544 | 0.002 | 5.81±0.63 | 12.09±1.21 | 6.650 | <0.001 |
SHR组 | 5 | 72.18±9.02a | 112.89±8.69ab | 12.290 | <0.001 | 19.76±0.51a | 33.94±3.16ab | 6.744 | <0.001 | 7.45±0.57 | 15.59±1.05ab | 11.180 | <0.001 |
SHR+NPS2143组 | 5 | 70.63±2.63 | 193.24±29.15 | 36.670 | <0.001 | 19.33±0.58 | 55.33±9.95 | 17.120 | <0.001 | 7.87±0.96 | 25.27±2.46 | 22.810 | <0.001 |
F值 | 9.796 | 222.700 | 138.700 | 45.340 | 1.062 | 84.190 | |||||||
P值 | 0.029 | <0.001 | <0.001 | <0.001 | 0.413 | 0.001 |
Table 4 Comparison of total retinal thickness in three group of rats at baseline and 16 weeks of intervention
组别 | 只数 | 视网膜总厚度 | 视网膜内丛状层厚度 | 视网膜内核层厚度 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
干预0周 | 干预16周 | t配对值 | P值 | 干预0周 | 干预16周 | t配对值 | P值 | 干预0周 | 干预16周 | t配对值 | P值 | ||
WKY组 | 5 | 56.08±4.69 | 95.01±1.36 | 14.430 | <0.001 | 12.59±1.99 | 22.23±1.69 | 4.544 | 0.002 | 5.81±0.63 | 12.09±1.21 | 6.650 | <0.001 |
SHR组 | 5 | 72.18±9.02a | 112.89±8.69ab | 12.290 | <0.001 | 19.76±0.51a | 33.94±3.16ab | 6.744 | <0.001 | 7.45±0.57 | 15.59±1.05ab | 11.180 | <0.001 |
SHR+NPS2143组 | 5 | 70.63±2.63 | 193.24±29.15 | 36.670 | <0.001 | 19.33±0.58 | 55.33±9.95 | 17.120 | <0.001 | 7.87±0.96 | 25.27±2.46 | 22.810 | <0.001 |
F值 | 9.796 | 222.700 | 138.700 | 45.340 | 1.062 | 84.190 | |||||||
P值 | 0.029 | <0.001 | <0.001 | <0.001 | 0.413 | 0.001 |
组别 | CaSR | VEGFA |
---|---|---|
WKY组 | 1±0 | 1±0 |
SHR组 | 0.35±0.03ab | 3.82±0.53ab |
SHR+NPS2143组 | 0.13±0.02 | 11.48±0.56 |
t值 | 1223 | 383 |
P值 | <0.001 | <0.001 |
Table 5 Expression of CaSR and VEGFA in retinal tissues in three groups of rats at 16 weeks of intervention
组别 | CaSR | VEGFA |
---|---|---|
WKY组 | 1±0 | 1±0 |
SHR组 | 0.35±0.03ab | 3.82±0.53ab |
SHR+NPS2143组 | 0.13±0.02 | 11.48±0.56 |
t值 | 1223 | 383 |
P值 | <0.001 | <0.001 |
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