Chinese General Practice ›› 2022, Vol. 25 ›› Issue (24): 3005-3012.DOI: 10.12114/j.issn.1007-9572.2022.0093
Special Issue: 阿尔茨海默病最新文章合集; 阿尔茨海默病最新文章合集
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Received:
2022-03-01
Revised:
2022-04-18
Published:
2022-08-20
Online:
2022-05-26
Contact:
Xulai ZHANG
About author:
通讯作者:
张许来
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0093
组别 | 例数 | MMSE评分〔M(P25,P75),分)〕 | BEHAVE-AD评分〔M(P25,P75),分)〕 | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
记忆力 | 视空间 | 注意集中 | 语言能力 | 定向力 | 总分 | 偏执和妄想 | 幻觉 | 行为紊乱 | 攻击行为 | 日夜节律紊乱 | 情感障碍 | 焦虑和恐惧 | 总分 | |||||
AD组 | 41 | 0(0,3.50) | 0(0,0.50) | 0(0,1.00) | 2.00(0,4.00) | 1.00(0,7.00) | 3.00(0,18.00) | 2.00(0,9.00) | 2.00(0,5.00) | 2.00(0,5.50) | 0(0,2.50) | 1.00(0,2.00) | 3.00(0,5.50) | 6.00(0,12.00) | 21.00(1.0,32.50) | |||
健康对照组 | 37 | 6.00(5.00,6.00) | 0(0,1.00) | 5.00(4.50,5.00) | 8.00(8.00,8.00) | 10.00(9.00,10.00) | 28.00(26.50,30.00) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
Z值 | -6.311 | -2.216 | -7.314 | -7.843 | -6.670 | -7.483 | -5.286 | -5.441 | -5.742 | -4.199 | -5.605 | -4.809 | -5.487 | -5.988 | ||||
P值 | <0.001 | 0.027 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | ||||
组别 | 脑内酰胺质子含量( | |||||||||||||||||
2 ut下右侧海马 | 2 ut下左侧海马 | 2 ut下海马(总) | 2 ut下右侧颞叶 | 2 ut下左侧颞叶 | 2 ut下颞叶(总) | 3 ut下右侧海马 | 3 ut下左侧海马 | 3 ut下海马(总) | 3 ut下右侧颞叶 | 3 ut下左侧颞叶 | 3 ut下颞叶(总) | 4 ut下右侧海马 | 4 ut下左侧海马 | 4 ut下海马(总) | 4 ut下右侧颞叶 | 4 ut下左侧颞叶 | 4 ut下颞叶(总) | |
AD组 | 0.90±0.25 | 1.26±0.35 | 2.02±0.56 | 0.76±.022 | 0.79±0.23 | 1.21±0.35 | 1.12±0.31 | 0.84±0.23 | 1.40±0.39 | 0.60±0.17 | 0.84±0.24 | 1.06±0.30 | 0.75±0.21 | 1.00±0.28 | 1.46±0.41 | 0.68±0.20 | 0.89±0.26 | 1.14±0.33 |
健康对照组 | 0.64±0.18 | 0.80±0.22 | 1.30±0.36 | 0.84±0.23 | 1.11±0.31 | 1.60±0.44 | 0.76±0.21 | 0.93±0.26 | 1.58±0.44 | 0.71±0.20 | 1.46±0.40 | 1.90±0.53 | 0.53±0.15 | 0.50±0.15 | 0.53±0.15 | 0.65±0.18 | 0.76±0.21 | 1.13±0.31 |
t值 | 2.893 | 3.344 | 3.403 | -0.421 | 1.092 | 0.507 | 1.549 | 3.249 | 2.923 | 0.472 | 1.145 | 1.086 | 2.559 | 3.785 | 3.778 | -1.383 | 0.519 | -0.431 |
P值 | 0.008 | 0.003 | 0.002 | 0.678 | 0.286 | 0.617 | 0.134 | 0.003 | 0.007 | 0.641 | 0.264 | 0.289 | 0.017 | 0.001 | 0.001 | 0.18 | 0.609 | 0.671 |
Table 1 Comparison of the total and domain scores of MMSE and BEHAVE-AD and cerebral amide proton content in Alzheimer's disease patients and healthy controls
组别 | 例数 | MMSE评分〔M(P25,P75),分)〕 | BEHAVE-AD评分〔M(P25,P75),分)〕 | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
记忆力 | 视空间 | 注意集中 | 语言能力 | 定向力 | 总分 | 偏执和妄想 | 幻觉 | 行为紊乱 | 攻击行为 | 日夜节律紊乱 | 情感障碍 | 焦虑和恐惧 | 总分 | |||||
AD组 | 41 | 0(0,3.50) | 0(0,0.50) | 0(0,1.00) | 2.00(0,4.00) | 1.00(0,7.00) | 3.00(0,18.00) | 2.00(0,9.00) | 2.00(0,5.00) | 2.00(0,5.50) | 0(0,2.50) | 1.00(0,2.00) | 3.00(0,5.50) | 6.00(0,12.00) | 21.00(1.0,32.50) | |||
健康对照组 | 37 | 6.00(5.00,6.00) | 0(0,1.00) | 5.00(4.50,5.00) | 8.00(8.00,8.00) | 10.00(9.00,10.00) | 28.00(26.50,30.00) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
Z值 | -6.311 | -2.216 | -7.314 | -7.843 | -6.670 | -7.483 | -5.286 | -5.441 | -5.742 | -4.199 | -5.605 | -4.809 | -5.487 | -5.988 | ||||
P值 | <0.001 | 0.027 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | ||||
组别 | 脑内酰胺质子含量( | |||||||||||||||||
2 ut下右侧海马 | 2 ut下左侧海马 | 2 ut下海马(总) | 2 ut下右侧颞叶 | 2 ut下左侧颞叶 | 2 ut下颞叶(总) | 3 ut下右侧海马 | 3 ut下左侧海马 | 3 ut下海马(总) | 3 ut下右侧颞叶 | 3 ut下左侧颞叶 | 3 ut下颞叶(总) | 4 ut下右侧海马 | 4 ut下左侧海马 | 4 ut下海马(总) | 4 ut下右侧颞叶 | 4 ut下左侧颞叶 | 4 ut下颞叶(总) | |
AD组 | 0.90±0.25 | 1.26±0.35 | 2.02±0.56 | 0.76±.022 | 0.79±0.23 | 1.21±0.35 | 1.12±0.31 | 0.84±0.23 | 1.40±0.39 | 0.60±0.17 | 0.84±0.24 | 1.06±0.30 | 0.75±0.21 | 1.00±0.28 | 1.46±0.41 | 0.68±0.20 | 0.89±0.26 | 1.14±0.33 |
健康对照组 | 0.64±0.18 | 0.80±0.22 | 1.30±0.36 | 0.84±0.23 | 1.11±0.31 | 1.60±0.44 | 0.76±0.21 | 0.93±0.26 | 1.58±0.44 | 0.71±0.20 | 1.46±0.40 | 1.90±0.53 | 0.53±0.15 | 0.50±0.15 | 0.53±0.15 | 0.65±0.18 | 0.76±0.21 | 1.13±0.31 |
t值 | 2.893 | 3.344 | 3.403 | -0.421 | 1.092 | 0.507 | 1.549 | 3.249 | 2.923 | 0.472 | 1.145 | 1.086 | 2.559 | 3.785 | 3.778 | -1.383 | 0.519 | -0.431 |
P值 | 0.008 | 0.003 | 0.002 | 0.678 | 0.286 | 0.617 | 0.134 | 0.003 | 0.007 | 0.641 | 0.264 | 0.289 | 0.017 | 0.001 | 0.001 | 0.18 | 0.609 | 0.671 |
MMSE评分 | BEHAVE-AD评分 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
记忆力 | 视空间 | 注意集中 | 语言能力 | 定向力 | 总分 | 偏执和妄想 | 幻觉 | 行为紊乱 | 攻击行为 | 日夜节律紊乱 | 情感障碍 | 焦虑和恐惧 | 总分 | |
2 ut下右侧海马 | -0.253 | -0.513 | -0.513 | -0.385 | -0.351 | -0.396 | 0.574a | 0.595a | -0.078 | 0.458 | 0.591a | -0.103 | 0.015 | 0.367 |
2 ut下左侧海马 | -0.033 | -0.228 | -0.228 | -0.148 | -0.160 | -0.216 | 0.039 | 0.217 | 0.025 | 0.207 | 0.006 | 0.029 | -0.039 | 0.099 |
2 ut下海马(总) | -0.275 | -0.513 | -0.513 | -0.358 | -0.364 | -0.405 | 0.325 | 0.458 | -0.050 | 0.396 | 0.335 | -0.072 | 0.033 | 0.232 |
3 ut下右侧海马 | 0.011 | -0.285 | -0.285 | -0.099 | -0.028 | -0.075 | 0.588a | 0.572a | -0.170 | 0.440 | 0.650a | -0.063 | -0.015 | 0.295 |
3 ut下左侧海马 | -0.490 | -0.285 | -0.285 | -0.443 | -0.590a | -0.509 | 0.006 | 0.103 | 0.095 | 0.225 | 0.112 | 0.078 | -0.006 | 0.061 |
3 ut下海马(总) | -0.301 | -0.513 | -0.513 | -0.301 | -0.323 | -0.324 | 0.625a | 0.606a | -0.097 | 0.548 | 0.611a | -0.049 | 0.039 | 0.359 |
4 ut下右侧海马 | -0.208 | 0.000 | 0.000 | -0.105 | -0.151 | -0.048 | 0.048 | 0.023 | 0.456 | 0.027 | -0.126 | 0.615a | 0.386 | 0.179 |
4 ut下左侧海马 | -0.732a | -0.570a | -0.570a | -0.292 | -0.449 | -0.312 | 0.171 | 0.092 | 0.287 | 0.324 | -0.041 | 0.322 | 0.224 | 0.135 |
4 ut下海马(总) | -0.542 | -0.342 | -0.342 | -0.196 | -0.276 | -0.165 | 0.056 | 0 | 0.387 | 0.144 | -0.156 | 0.580a | 0.338 | 0.105 |
Table 2 Correlation analysis of cerebral amide proton content with the total and domain scores of MMSE and BEHAVE-AD in Alzheimer's disease patients
MMSE评分 | BEHAVE-AD评分 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
记忆力 | 视空间 | 注意集中 | 语言能力 | 定向力 | 总分 | 偏执和妄想 | 幻觉 | 行为紊乱 | 攻击行为 | 日夜节律紊乱 | 情感障碍 | 焦虑和恐惧 | 总分 | |
2 ut下右侧海马 | -0.253 | -0.513 | -0.513 | -0.385 | -0.351 | -0.396 | 0.574a | 0.595a | -0.078 | 0.458 | 0.591a | -0.103 | 0.015 | 0.367 |
2 ut下左侧海马 | -0.033 | -0.228 | -0.228 | -0.148 | -0.160 | -0.216 | 0.039 | 0.217 | 0.025 | 0.207 | 0.006 | 0.029 | -0.039 | 0.099 |
2 ut下海马(总) | -0.275 | -0.513 | -0.513 | -0.358 | -0.364 | -0.405 | 0.325 | 0.458 | -0.050 | 0.396 | 0.335 | -0.072 | 0.033 | 0.232 |
3 ut下右侧海马 | 0.011 | -0.285 | -0.285 | -0.099 | -0.028 | -0.075 | 0.588a | 0.572a | -0.170 | 0.440 | 0.650a | -0.063 | -0.015 | 0.295 |
3 ut下左侧海马 | -0.490 | -0.285 | -0.285 | -0.443 | -0.590a | -0.509 | 0.006 | 0.103 | 0.095 | 0.225 | 0.112 | 0.078 | -0.006 | 0.061 |
3 ut下海马(总) | -0.301 | -0.513 | -0.513 | -0.301 | -0.323 | -0.324 | 0.625a | 0.606a | -0.097 | 0.548 | 0.611a | -0.049 | 0.039 | 0.359 |
4 ut下右侧海马 | -0.208 | 0.000 | 0.000 | -0.105 | -0.151 | -0.048 | 0.048 | 0.023 | 0.456 | 0.027 | -0.126 | 0.615a | 0.386 | 0.179 |
4 ut下左侧海马 | -0.732a | -0.570a | -0.570a | -0.292 | -0.449 | -0.312 | 0.171 | 0.092 | 0.287 | 0.324 | -0.041 | 0.322 | 0.224 | 0.135 |
4 ut下海马(总) | -0.542 | -0.342 | -0.342 | -0.196 | -0.276 | -0.165 | 0.056 | 0 | 0.387 | 0.144 | -0.156 | 0.580a | 0.338 | 0.105 |
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