柴胡加龙骨牡蛎汤联合失眠认知行为疗法治疗肝郁化火型急性失眠的临床疗效研究

doi:10.12114/j.issn.1007-9572.2025.0271

中国全科医学 ›› 2026, Vol. 29 ›› Issue (13): 1666-1672.DOI: 10.12114/j.issn.1007-9572.2025.0271

柴胡加龙骨牡蛎汤联合失眠认知行为疗法治疗肝郁化火型急性失眠的临床疗效研究

余学芳¹, 朱敏², 马清林², 谭神朗², 吴子幸³^,^*(), 江伟³^,^*()

1．230031　安徽省合肥市，中国人民解放军联勤保障部队第九〇一医院中医科
2．241003　安徽省芜湖市，皖南医学院研究生学院
3．230031　安徽省合肥市，中国人民解放军联勤保障部队第九〇一医院全科医学科

收稿日期:2025-04-10 修回日期:2025-11-20 出版日期:2026-05-05 发布日期:2026-04-14
通讯作者: 吴子幸, 江伟
作者贡献：
余学芳主要负责研究框架的构建、论文撰写；朱敏、马清林共同承担实验数据的采集与整理；谭神朗负责研究数据的统计处理与分析；吴子幸、江伟负责研究方向的确定、实验方案设计，并对论文终稿进行审阅与修改。
基金资助:
安徽省重点研究与开发计划项目(202104j07020002); 安徽医科大学校科学基金项目(2022xkj251，2023xkj125); 中国人民解放军联勤保障部队第九〇一医院院级项目(2023YGYB02)

Clinical Efficacy of Chaihu Longgu Muli Decoction Combined with Cognitive Behavioral Therapy in the Treatment of Acute Insomnia of Liver Qi Stagnation with Fire Transformation Type

YU Xuefang¹, ZHU Min², MA Qinglin², TAN Shenlang², WU Zixing³^,^*(), JIANG Wei³^,^*()

1. Department of Traditional Chinese Medicine, the 901th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Hefei 230031, China
2. Graduate School, Wannan Medical College, Wuhu 241003, China
3. Department of General Practice, the 901th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Hefei 230031, China

Received:2025-04-10 Revised:2025-11-20 Published:2026-05-05 Online:2026-04-14
Contact: WU Zixing, JIANG Wei

分享到

摘要/Abstract

摘要： 背景肝郁化火型急性失眠源于情志失调，致扰心失眠，治疗以疏肝解郁、清热泻火、安神为主，柴胡加龙骨牡蛎汤具有镇静安神之功效，失眠认知行为疗法（CBT-I）被推荐为非药物治疗失眠的首选方案。目前有关柴胡加龙骨牡蛎汤联合CBT-I治疗肝郁化火型急性失眠的研究尚少。目的本研究旨在评估柴胡加龙骨牡蛎汤联合CBT-I治疗肝郁化火型急性失眠患者的临床疗效。方法选取2023年3月—2024年9月在中国人民解放军联勤保障部队第九〇一医院就诊的90例符合肝郁化火型急性失眠诊断标准的患者为研究对象。根据随机数字表法将患者分为对照组（45例）和观察组（45例）。对照组接受CBT-I干预，观察组则在CBT-I基础上联合应用柴胡加龙骨牡蛎汤治疗，两组均接受4周干预。研究评估指标包括：（1）临床症状改善情况（中医证候积分）；（2）睡眠质量参数[匹兹堡睡眠质量指数（PSQI）评分、光电容积脉搏波描记法（PPG）监测指标]；（3）情绪状态指标[汉密尔顿焦虑量表（HAMA）评分、汉密尔顿抑郁量表（HAMD）评分]；（4）血清生物标志物水平[肿瘤坏死因子α（TNF-α）、白介素1β（IL-1β）、5-羟色胺（5-HT）]；（5）临床疗效及安全性。结果观察组临床总有效率[88.89%（40/45）]优于对照组[66.67%（30/45）]（χ2=14.284，P<0.05）。组内比较显示，与治疗前比较，两组治疗后总睡眠时间、睡眠效率和5-HT水平提升（P<0.05），而睡眠潜伏期、觉醒次数、PSQI评分、HAMA评分、HAMD评分、中医证候积分及炎症因子（TNF-α、IL-1β）水平降低（P<0.05）。治疗后组间比较表明，观察组上述指标均优于对照组（P<0.05）。对照组和观察组不良事件发生率比较，差异无统计学意义（χ2=0.511，P>0.05）。结论柴胡加龙骨牡蛎汤联合CBT-I治疗肝郁化火型急性失眠安全可行，能有效改善患者的睡眠质量、缓解情绪障碍、降低中医症候评分、调节神经递质水平和抑制炎症反应，治疗效果优于单独使用CBT-I。

关键词: 入睡和睡眠障碍, 急性失眠, 肝郁化火型, 柴胡加龙骨牡蛎汤, 失眠认知行为疗法

Abstract:

Background

Acute insomnia with liver qi stagnation and fire transformation type originates from emotional imbalance, which disturbs the heart and causes sleeplessness. The treatment focuses on soothing the liver, relieving depression, clearing heat, purging fire, and calming the mind. Chaihu Longgu Muli Decoction has the effect of calming and soothing the mind, and Cognitive Behavioral Therapy for Insomnia (CBT-I) is recommended as the first choice for non-drug treatment of insomnia. At present, there are few studies on Chaihu Longgu Muli Decoction combined with CBT-I in the treatment of acute insomnia with liver qi stagnation and fire transformation type.

Objective

The purpose of this study is to systematically evaluate the clinical effect of Chaihu Longgu Muli Decoction combined with CBT-I on acute insomnia patients with liver qi stagnation and fire transformation type.

Methods

From March 2023 to September 2024, 90 patients who met the diagnostic criteria of acute insomnia with liver qi stagnation and fire transformation type at the 901th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army were selected as the research objects. According to the table of random numbers method, patients were divided into control group (45 cases) and observation group (45 cases). The control group received CBT-I intervention, while the observation group was treated with Chaihu Longgu Muli Decoction on the basis of CBT-I. Both groups received intervention for 4 weeks. Research evaluation indicators include: (1) Clinical symptom improvement [traditional Chinese medicine (TCM) syndrome score]; (2) Sleep quality parameters [Pittsburgh Sleep Quality Index (PSQI) score, photoplethysmography (PPG) monitoring indicators]; (3) Mood state indicators [Hamilton Anxiety Scale (HAMA) score, Hamilton Depression Scale (HAMD) score]; (4) Serum biomarker levels [Tumor Necrosis Factor-alpha (TNF-α), Interleukin-1beta (IL-1β), 5-Hydroxytryptamine (5-HT) ]; (5) Clinical efficacy and safety.

Results

The clinical total effective rate of the observation group [88.89% (40/45) ] was significantly better than that of the control group [66.67% (30/45), χ²=14.284, P<0.05]. Intra-group comparison showed that compared with before treatment, the total sleep time, sleep efficiency and 5-HT level in the two groups were significantly increased (P<0.05), while the sleep latency, awakening times, PSQI score, HAMA score, HAMD score, TCM syndrome score and inflammatory factors (TNF-α, IL-1β) levels were significantly decreased (P<0.05). The comparison between groups showed that the above indexes in the observation group were significantly better than those in the control group (P<0.05). There was no significant difference in the incidence of adverse events between the two groups (χ²=0.511, P>0.05) .

Conclusion

The combination of Chaihu Longgu Muli Decoction with CBT-I is safe and feasible for treating acute insomnia with liver qi stagnation and fire transformation type. It effectively improves patients' sleep quality, alleviates emotional disturbances, reduces TCM symptom scores, regulates neurotransmitter levels, and suppresses inflammatory responses. The therapeutic efficacy surpasses that of CBT-I alone.

Key words: Sleep initiation and maintenance disorders, Acute insomnia, Liver qi stagnation with fire transformation, Chaihu longgu muli decoction, Cognitive behavioral therapy

中图分类号:

R 741

余学芳,朱敏,马清林,等. 柴胡加龙骨牡蛎汤联合失眠认知行为疗法治疗肝郁化火型急性失眠的临床疗效研究[J]. 中国全科医学, 2026, 29(13): 1666-1672. DOI: 10.12114/j.issn.1007-9572.2025.0271.
YU Xuefang,ZHU Min,MA Qinglin, et al. Clinical Efficacy of Chaihu Longgu Muli Decoction Combined with Cognitive Behavioral Therapy in the Treatment of Acute Insomnia of Liver Qi Stagnation with Fire Transformation Type[J]. Chinese General Practice, 2026, 29(13): 1666-1672. DOI: 10.12114/j.issn.1007-9572.2025.0271.

图/表 6

参考文献 36

[1]	PERLIS M L, VARGAS I, ELLIS J G, et al. The natural history of insomnia: the incidence of acute insomnia and subsequent progression to chronic insomnia or recovery in good sleeper subjects[J]. Sleep, 2020, 43(6): zsz299. DOI: 10.1093/sleep/zsz299.
[2]	DE CRESCENZO F, D'ALÒ G L, OSTINELLI E G, et al. Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis[J]. Lancet, 2022, 400(10347): 170-184.
[3]	BARROSO D, HESPANHOL L, SIEGLOCH M L, et al. Effect of minimal cognitive behavioral therapy for patients with acute insomnia: a systematic review and meta-analysis[J]. Sleep Med, 2024, 122: 171-176. DOI: 10.1016/j.sleep.2024.08.003.
[4]	KOZOLE SMID A K, MLAKAR A, ŠTUKOVNIK V. Toxicity of benzodiazepines in the treatment of insomnia disorders in older adults: a systematic literature review[J]. Croat Med J, 2024, 65(2): 146-155.
[5]	EL-SOLH A A, MARTINSON A, ATTAI P, et al. Determinants of treatment response to cognitive behavioral therapy in veterans presenting with comorbid insomnia and sleep apnea[J]. Sleep Breath, 2025, 29(2): 129. DOI: 10.1007/s11325-025-03298-z.
[6]	中医科学院失眠症中医临床实践指南课题组. 失眠症中医临床实践指南(WHO/WPO)[J]. 世界睡眠医学杂志, 2016, 3(1): 8-25.
[7]	朱佳欣，苏广，蔡冬美，等. 疏肝调神耳穴刮痧法联合耳尖放血治疗肝郁化火型失眠临床研究[J]. 新中医, 2024, 56(13): 203-207.
[8]	李乐，杨叔禹. 杨叔禹从肝脾论治失眠经验[J]. 中医杂志, 2022, 63(23): 2218-2222. DOI: 10.13288/j.11-2166/r.2022.23.004.
[9]	袁江芳，郭秀霞. 加减柴胡加龙骨牡蛎汤对肝气郁滞型更年期失眠的影响[J]. 内蒙古中医药, 2024, 43(11): 55-57.
[10]	SATEIA M J. International classification of sleep disorders-third edition: highlights and modifications[J]. Chest, 2014, 146(5): 1387-1394. DOI: 10.1378/chest.14-0970.
[11]	BUYSSE DJ, REYNOLDS CF 3RD, MONK TH, et al. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research[J]. Psychiatry Res, 1989, 28(2): 193-213.
[12]	HAMILTON M. The assessment of anxiety states by rating[J]. Br J Med Psychol, 1959, 32(1): 50-55.
[13]	HAMILTON M. A rating scale for depression[J]. J Neurol Neurosurg Psychiatry, 1960, 23(1): 56-62. DOI: 10.1136/jnnp.23.1.56.
[14]	BOYLE J T, MORALES K H, MUENCH A, et al. The natural history of insomnia: evaluating illness severity from acute to chronic insomnia; is the first the worst [J]. Sleep, 2024, 47(4): zsae034.
[15]	WALKER J L, VARGAS I, DRAKE C L, et al. The natural history of insomnia: high sleep reactivity interacts with greater life stress to predict the onset of acute insomnia[J]. Sleep, 2022, 45(9): zsac149.
[16]	张硕华，王敬卿. 基于"阳不入阴"理论探讨围绝经期失眠之辨治[J]. 江苏中医药, 2024, 56(6): 30-33.
[17]	杨栋峰. 五脏失眠的中医调摄方法研究[D]. 南昌: 江西中医药大学, 2021.
[18]	韩珊，冯智伟，吕桃桃，等. 针刺联合睡眠卫生教育治疗肝郁化火型急性失眠的临床效果[J]. 中国医药导报, 2024, 21(28): 119-123, 137. DOI: 10.20047/j.issn1673-7210.2024.28.22.
[19]	SMID A K K, MLAKAR A, ŠTUKOVNIK V. Toxicity of benzodiazepines in the treatment of insomnia disorders in older adults: a systematic literature review[J]. Croat Med J, 2024, 65(2): 146-155. DOI: 10.3325/cmj.2024.65.146.
[20]	DOROOSHI G, KERMANI R, SABZGHABAEE A M, et al. Comparison of clinical manifestations of patients poisoned with tricyclic antidepressants alone or with benzodiazepine intoxication according to the dose of benzodiazepines[J]. J Res Pharm Pract, 2022, 11(2): 59-63. DOI: 10.4103/jrpp.jrpp_43_21.
[21]	MIJNSTER T, BOERSMA G J, MEIJER E, et al. Effectivity of (personalized) cognitive behavioral therapy for insomnia in mental health populations and the elderly: an overview[J]. J Pers Med, 2022, 12(7): 1070. DOI: 10.3390/jpm12071070.
[22]	刘恒亮，金子轩，苏克雷，等. 基于现代病理生理机制的柴胡加龙骨牡蛎汤方证解读及临床运用体会[J]. 中国中药杂志, 2023, 48(10): 2620-2624. DOI: 10.19540/j.cnki.cjcmm.20230206.501.
[23]	王嘉昀，高祖，高琳，等. 经方柴胡加龙骨牡蛎汤的研究进展及质量标志物预测分析[J]. 中华中医药学刊, 2023, 41(4): 29-36.
[24]	李肃义，姜珊，刘丽佳，等. 光电容积脉搏波的睡眠呼吸暂停综合征筛查方法[J]. 光谱学与光谱分析, 2019, 39(6): 1852-1857.
[25]	CHEN H B, ZENG G Y, WU S F, et al. Efficacy and safety of escitalopram combined with tandospirone citrate in treating patients with vascular depression and chronic insomnia: a randomized controlled trial[J]. CNS Drugs, 2025, 39(7): 669-683.
[26]	王静，侯婉婷，秦雪梅，等. 昼夜节律的相关研究进展[J]. 中国中药杂志, 2021, 46(13): 3240-3248.
[27]	BESEDOVSKY L, LANGE T, HAACK M. The sleep-immune crosstalk in health and disease[J]. Physiol Rev, 2019, 99(3): 1325-1380. DOI: 10.1152/physrev.00010.2018.
[28]	WANG J H, WU X L, LIANG W J, et al. Objective short sleep duration is related to the peripheral inflammasome dysregulation in patients with chronic insomnia[J]. Nat Sci Sleep, 2020, 12: 759-766.
[29]	WALKER J L, SLAVISH D C, DOLAN M, et al. Age-dependent associations among insomnia, depression, and inflammation in nurses[J]. Psychol Health, 2021, 36(8): 967-984.
[30]	ZHANG F, HAN X L, MU Q S, et al. Elevated cerebrospinal fluid biomarkers of neuroinflammation and neuronal damage in essential hypertension with secondary insomnia: implications for Alzheimer's disease risk[J]. Brain Behav Immun, 2025, 125: 158-167.
[31]	LI L Y, LIU S Z, YU X C, et al. Liuwei Anshen Capsule alleviates cognitive impairment induced by sleep deprivation by reducing neuroapoptosis and inflammation[J]. J Ethnopharmacol, 2025, 341: 119311. DOI: 10.1016/j.jep.2024.119311.
[32]	吴子幸，胡欣，陶诗萌，等. 老年慢性失眠患者认知功能与失眠严重程度和血清25-羟维生素D₃及肿瘤坏死因子α水平的相关性研究[J]. 中国全科医学, 2024, 27(3): 328-334.
[33]	DITMER M, GABRYELSKA A, TURKIEWICZ S, et al. The influence of serotonergic signaling on quality of life, depression, insomnia, and hypoxia in obstructive sleep apnea patients: cross-sectional study[J]. J Clin Med, 2025, 14(2): 445.
[34]	MAIEREAN A D, BORDEA I R, SALAGEAN T, et al. Polymorphism of the serotonin transporter gene and the peripheral 5-hydroxytryptamine in obstructive sleep apnea: what do we know and what are we looking for a systematic review of the literature[J]. Nat Sci Sleep, 2021, 13: 125-139. DOI: 10.2147/NSS.S278170.
[35]	WITKOWSKA A, JAROMIRSKA J, GABRYELSKA A, et al. Obstructive sleep apnea and serotoninergic signalling pathway: pathomechanism and therapeutic potential[J]. Int J Mol Sci, 2024, 25(17): 9427. DOI: 10.3390/ijms25179427.
[36]	吴圆圆. 基于5-HT通路探讨柴胡加龙骨牡蛎汤治疗2型糖尿病合并抑郁患者的作用机制[D]. 哈尔滨: 黑龙江省中医药科学院, 2022.

组别	例数	年龄（±s，岁）	性别（男/女）	BMI （±s，kg/m²）	病程（±s，周）	文化程度[例（%）]
组别	例数	年龄（±s，岁）	性别（男/女）	BMI （±s，kg/m²）	病程（±s，周）	小学或初中	高中或中专	大专及以上
对照组	45	38.5±10.2	25/20	24.11±3.02	8.73±3.00	7（15.6）	15（33.3）	23（51.1）
观察组	45	37.8±9.3	28/17	24.26±2.68	8.38±2.71	8（17.8）	17（37.8）	20（44.4）
t（χ²）值		0.312	0.413^a	0.243	0.590	0.401^a
P值		0.756	0.520	0.808	0.557	0.818

组别	例数	年龄（±s，岁）	性别（男/女）	BMI （±s，kg/m²）	病程（±s，周）	文化程度[例（%）]
组别	例数	年龄（±s，岁）	性别（男/女）	BMI （±s，kg/m²）	病程（±s，周）	小学或初中	高中或中专	大专及以上
对照组	45	38.5±10.2	25/20	24.11±3.02	8.73±3.00	7（15.6）	15（33.3）	23（51.1）
观察组	45	37.8±9.3	28/17	24.26±2.68	8.38±2.71	8（17.8）	17（37.8）	20（44.4）
t（χ²）值		0.312	0.413^a	0.243	0.590	0.401^a
P值		0.756	0.520	0.808	0.557	0.818

组别	例数	痊愈	显效	有效	无效
对照组	45	6（13.33）	8（17.78）	16（35.56）	15（33.33）
观察组	45	14（33.11）	16（33.56）	10（22.22）	5（11.11）

组别	例数	痊愈	显效	有效	无效
对照组	45	6（13.33）	8（17.78）	16（35.56）	15（33.33）
观察组	45	14（33.11）	16（33.56）	10（22.22）	5（11.11）

组别	例数	总睡眠时间（min）		睡眠潜伏期（min）		睡眠效率（%）		觉醒次数（次）
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	45	349.71±49.90	390.44±66.36^a	37.16±13.25	31.64±9.79^a	63.43±12.30	72.54±12.48^a	10.87±4.76	7.20±3.70^a
观察组	45	345.96±44.75	420.16±70.22^ab	36.38±12.46	26.62±9.21^ab	63.11±10.49	79.86±9.51^ab	11.64±5.33	4.93±2.20^ab
t值		0.376	2.063	0.287	2.507	0.135	3.132	0.731	3.531
P值		>0.05	<0.05	>0.05	<0.05	>0.05	<0.01	>0.05	<0.01

柴胡加龙骨牡蛎汤联合失眠认知行为疗法治疗肝郁化火型急性失眠的临床疗效研究

Clinical Efficacy of Chaihu Longgu Muli Decoction Combined with Cognitive Behavioral Therapy in the Treatment of Acute Insomnia of Liver Qi Stagnation with Fire Transformation Type

RichHTML

PDF

可视化

摘要/Abstract

引用本文

使用本文

图/表 6

参考文献 36

相关文章 14

编辑推荐

Metrics

留言

[1]	中国康复医学会社区康复工作委员会. 虚拟现实技术应用于肿瘤相关性失眠居家康复的专家共识（2025年版）[J]. 中国全科医学, 2025, 28(35): 4385-4396.
[2]	张红石, 曲子涵, 孙雪峰, 王宇峰, 丛德毓, 张野. 基于蛋白质组学技术分析腹部推拿对失眠大鼠下丘脑的影响研究[J]. 中国全科医学, 2025, 28(27): 3399-3409.
[3]	吴子幸, 胡欣, 陶诗萌, 何友军, 蔡传云, 江伟. 老年慢性失眠患者认知功能与失眠严重程度和血清25-羟维生素D₃及肿瘤坏死因子α水平的相关性研究[J]. 中国全科医学, 2024, 27(03): 328-334.
[4]	朱琳, 郭闫葵, 高琛, 陈学志, 王法帅. 单纯西药、中成药及其联合治疗卒中后失眠疗效的网状Meta分析[J]. 中国全科医学, 2023, 26(30): 3823-3832.
[5]	陈品琪, 张丽清, 向婷, 孙熙哲, 潘集阳. 静息态功能磁共振局部一致性在抑郁障碍伴失眠症状患者中的研究进展[J]. 中国全科医学, 2022, 25(35): 4462-4467.
[6]	郭琛琛, 鹿海峰, 庄贺, 李丽, 王从安, 丁懿. "五音调神"法治疗卒中后失眠的临床疗效及机制研究[J]. 中国全科医学, 2022, 25(12): 1475-1481.
[7]	王月莹，牟云平，尹又，朱冰倩. 电子化认知行为疗法治疗失眠效果的系统评价[J]. 中国全科医学, 2021, 24(35): 4516-4524.
[8]	黄柳，张希，蔡春凤. 心血管疾病患者内感觉意识、焦虑敏感性与失眠症状的关系研究[J]. 中国全科医学, 2020, 23(25): 3188-3193.
[9]	郑亚威, 吴力菲, 张星星, 顾冬梅, 张思奇, 刘鸣, 方祝元. 中医药疗法对冠心病并发失眠疗效的网状Meta分析[J]. 中国全科医学, 2020, 23(2): 227-233.
[10]	周其达，范健，秦琳，华键，韩杨，查蕾蕾，周卫，周玉洁. 低剂量佐匹克隆延迟控释片治疗早醒性失眠的疗效研究[J]. 中国全科医学, 2019, 22(33): 4078-4082.
[11]	邢佳，董斐，张迎，秦裕驹. 慢性失眠症诊断与团体心理行为治疗的研究进展[J]. 中国全科医学, 2019, 22(30): 3762-3767.
[12]	杨瑛，孙艳格，闫岩，李超，吕凯敏. 社区规范化管理老年慢性病患者镇静催眠药使用情况研究[J]. 中国全科医学, 2019, 22(13): 1613-1617.
[13]	奎瑜，陈秀华，徐振华，陈全新，李颖，王聪，黄彬城，张圣浩 . 陈氏飞针治疗椎动脉型颈椎病伴失眠的临床研究[J]. 中国全科医学, 2016, 19(21): 2553-2556.
[14]	魏婷婷，陈小岑，侯云霞，阎玲，王平. 肺癌化疗患者癌因性失眠及肿瘤相关症状调查研究[J]. 中国全科医学, 2015, 18(21): 2564-2567,2572.

组别	例数	PSQI评分		HAMA评分		HAMD评分
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	45	12.36±2.67	7.80±2.24 ^a	14.02±1.57	11.47±1.22 ^a	15.22±1.81	12.34±1.74 ^a
观察组	45	12.11±1.56	6.44±2.11^ab	14.24±1.82	9.44±1.01 ^ab	15.71±1.90	10.18±1.11^ab
t值		0.530	2.956	0.619	8.568	1.250	7.022
P值		>0.05	<0.01	>0.05	<0.01	>0.05	<0.01

组别	例数	PSQI评分		HAMA评分		HAMD评分
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	45	12.36±2.67	7.80±2.24 ^a	14.02±1.57	11.47±1.22 ^a	15.22±1.81	12.34±1.74 ^a
观察组	45	12.11±1.56	6.44±2.11^ab	14.24±1.82	9.44±1.01 ^ab	15.71±1.90	10.18±1.11^ab
t值		0.530	2.956	0.619	8.568	1.250	7.022
P值		>0.05	<0.01	>0.05	<0.01	>0.05	<0.01

组别	例数	主证		次证		舌脉
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	45	13.91±3.85	8.04±2.24^a	11.56±2.33	5.20±1.79^a	5.33±1.78	2.87±1.14^a
观察组	45	13.13±2.98	5.22±1.76^ab	11.24±2.13	3.78±1.13^ab	5.27±1.76	1.76±0.74^ab
t值		1.072	6.659	0.661	4.509	0.178	5.476
P值		>0.05	<0.01	>0.05	<0.01	>0.05	<0.01

组别	例数	主证		次证		舌脉
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	45	13.91±3.85	8.04±2.24^a	11.56±2.33	5.20±1.79^a	5.33±1.78	2.87±1.14^a
观察组	45	13.13±2.98	5.22±1.76^ab	11.24±2.13	3.78±1.13^ab	5.27±1.76	1.76±0.74^ab
t值		1.072	6.659	0.661	4.509	0.178	5.476
P值		>0.05	<0.01	>0.05	<0.01	>0.05	<0.01