Medical insurance payment is an important link in deepening medical reform, and an important lever for regulating medical service behavior and guiding the allocation of medical resources. At present, China's medical insurance reform tends to pay according to health outcomes, and the trend is from "cure" to "prevention". DIP payment is an important manifestation of health outcome payment in medical reform. General practitioners are the first line of defense to protect the health of the whole people, and the general practice department of general hospitals undertakes the task of promoting hierarchical medical system and the dual referral system. The full-cycle, standardized and refined diagnosis and treatment mode of general practitioners is the prerequisite for the successful implementation of DIP payment, and the connotation of DIP reflects the work value of general practitioners, and the two complement and promote each other. By illustrating the definition and connotation of DIP payment, this paper reviews the process of medical insurance reform in China, sorts out the excellent practice cases of domestic medical institutions implementing DIP payment, analyzes the difficulties and shortcomings in the work and management of general medicine in general hospitals in China. On this basis, it is proposed that a high-quality and efficient medical and health service system and an evaluation index system should be built, combining prevention and treatment with professional characteristics to promote mutual benefit between doctors and patients, relieve the pressure of medical insurance, promote the integration of medical insurance and improve the ability to control costs. This study aims to provide reference for the adaptation of general practice departments to medical insurance reform in domestic general hospitals.