中性粒细胞与淋巴细胞比值在心血管疾病中作用的研究进展

doi:10.12114/j.issn.1007-9572.2019.00.819

摘要/Abstract

摘要： 中性粒细胞与淋巴细胞比值（NLR）是一种新型的炎性标志物，其与肿瘤、脓毒症、急性胰腺炎等多种疾病密切相关。近年来研究发现NLR参与心血管疾病的发生发展，对多种心血管疾病具有重要的预测价值。本文介绍了NLR在心血管疾病（包括冠心病、心力衰竭、高血压、心律失常、心脏瓣膜病）中作用的研究进展，NLR可以预测冠心病患者的近、远期死亡率及主要不良心血管事件。较高的NLR与急性失代偿性心力衰竭患者短期内再入院风险增加及远期死亡率有关。NLR对高血压患者的舒张功能障碍和全因死亡率、心房颤动的新发和射频消融术后的复发均有较好的预测价值。NLR对经导管主动脉瓣置换术的患者具有一定的预后作用。NLR以其价格低廉、立即获得、可重复检测等特点，在社区及基层医疗机构可以获得很大的优势，以期为心血管疾病的诊疗提供新方向。

关键词: 心血管疾病, 中性粒细胞与淋巴细胞比值, 炎性标志物, 综述

Abstract: Neutrophil-to-lymphocyte-ratio（NLR） is a novel inflammatory marker，which is closely related to tumor，sepsis，acute pancreatitis and other diseases.Recent studies have found that NLR is involved in the occurrence and development of cardiovascular diseases and has important predictive value for a variety of cardiovascular diseases.This article introduces the research progress of NLR in cardiovascular diseases，including coronary heart disease，heart failure，hypertension，arrhythmia and heart valve disease，NLR can predict the near and long term mortality and major adverse cardiovascular events in patients with coronary heart disease.Higher NLR is associated with an increased risk of short-term readmissions and long-term mortality in patients with acute decompensated heart failure.NLR is a predictor of diastolic dysfunction and all-cause mortality in patients with hypertension.NLR has a good predictive value for new onset of atrial fibrillation and recurrence after radiofrequency ablation.NLR has a prognostic value for patients undergoing transcatheter aortic valve replacement.NLR has many advantages in community and grass-roots medical institutions due to its low price，immediate access，and repeatable detection，in order to provide a new direction for the diagnosis and treatment of cardiovascular diseases.

Key words: Cardiovascular diseases, Neutrophil-to-lymphocyte-ratio, Inflammatory maker, Review

邱乐,刘奇志. 中性粒细胞与淋巴细胞比值在心血管疾病中作用的研究进展[J]. 中国全科医学, 2020, 23(12): 1559-1565. DOI: 10.12114/j.issn.1007-9572.2019.00.819.
QIU Le,LIU Qizhi. Advances in Research on the Role of NLR in Cardiovascular Diseases　[J]. Chinese General Practice, 2020, 23(12): 1559-1565. DOI: 10.12114/j.issn.1007-9572.2019.00.819.

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