关键词: 文献计量学, 处方精简, Web of Science, 老年人, 多重用药

Abstract: Background　Inappropriate polypharmacy，especially in older people，imposes substantial burden of adverse drug events，illness，disability，hospitalization and even death.Deprescribing is the process of tapering or stopping drugs，aimed at minimizing polypharmacy and improving patient outcomes.Objective　To search and analyze theoriginal researches on deprescribing from 2013 to 2018 in Web of Science，and to explore the literature distribution and research focus.Methods　The retrieval date was October 10，2018.We searched medical subject headings in Web of Science Core Collection Databases，set the date ranged from 2003 to 2018 and the search formula was as follows：subject=（"deprescribing"） OR topic=（"deprescribe"）．Firstly，the retrieved literature were screened according to the inclusion criteria.Then the included literature were analyzed by bibliometric through EndNote 8.0 and the analysis and retrieval tools in Web of Science.Results　A total of 70 original research papers were included in the study.From 2012 to 2014，two articles about deprescribing were published（accounting for 2.9%）．The number of published articles began to increase and 5 articles（accounting for 7.1%） were published in 2015.From January 2016 to October 2018，the number of published articles increased rapidly 〔a total of 63 articles（accounting for 90.0%）〕.BMJ Open and European Journal of Hospital Pharmacy Science and Practice published the largest number of papers（each with 5 papers），and seven SCI journals published three or more papers each.In addition，BMC Medicine had the highest influence factor（IF=9.08）．There were 21 highly cited papers（citation≥7）．The included literature were from 17 countries and regions，among which Canada，Australia and the United States were the three countries with the largest number of publications.The average author cooperation degree of the literature was 5.4，that is，each paper has an average of 5-6 authors.And the average institutional cooperation degree was 3.0，that is，an average of three institutions participated in the research of each paper.The analysis of the occupational distribution of the first authors showed that most of them were clinical pharmacists，public health scholars and general practitioners.And the research disciplines of the included literature were mainly pharmacy and internal medicine，followed by geriatrics.Conclusion　Although research on deprescribing is still at an early stage，it has become a research focus.The number of published literature has increased rapidly since 2016 and Canadian，Australian and American scholars have published the most number of papers.The first authors of published literature were mainly pharmacists，public health researchers and general practitioners.

Key words: 　Bibliometrics, Deprescribing, Web of Science, Aged, Multiple drug use