关键词: 双向情感障碍, 诊断, 抑郁, 药物使用, 不良反应, 初次发病年龄

Abstract: Background　Bipolar disorder（BPD）is a severe mental disorder with a wide incidence and difficulty in treatment.Currently，clinical diagnosis and treatment guidelines in China are based on clinical survey data from foreign countries.Relevant data in China is rare.Objective　To understand the diagnosis and medication situation of patients with BPD in Wenzhou in order to make up for the lack of regional data and provide references for the clinical guidelines based on China's national conditions.Methods　A cross-sectional random sampling method was used to distribute a self-made questionnaire to doctors on duty in neurological/psychiatric departments randomly selected in 10 hospitals in Wenzhou from May 15 to 19 in 2017.The questionnaire was a mixed form that includes patients' essential information，initial onset status，age at which the diagnosis was determined，the time from the first diagnosis，drug use，doses，current adverse reactions，and the next medication plan.Results　A total of 150 questionnaires were distributed and 127 valid questionnaires were returned.The effective recovery rate was 84.7%.The initial onset age was 8 to 56；the age at which the diagnosis was determined was 8 to 78；the time from the first diagnosis was 1 month to 33 years.The most commonly used pharmacological agent was quetiapine with 77 times.Obesity was the most common adverse reaction with 41 cases.There were 106 cases in the medication maintenance period.The average doses of quetiapine，magnesium valproate，and lithium carbonate in maintenance period were 0.50 g/d，1.00 g/d，and 0.85 g/d，respectively.Conclusion　The situation in Wenzhou is different from what reported in other regions at home and abroad.Based on different regional situation，deeper and larger-scale investigations should be started as soon as possible to better provide more information for clinical diagnosis and treatment of BPD.

Key words: Bipolar disorder, Diagnosis, Depression, Medication used, Adverse reaction, Age at onset