关键词: 甲状腺疾病, 促甲状腺素, 甲状腺自身抗体, 尿碘, 甲状腺体积, 合肥

Abstract: Background　Iodine is one of the important raw materials for the synthesis of thyroid hormones in the thyroid.Previous studies have shown that excessive iodine intake induces the production of anti-thyroid antibodies.Our previous survey results show that excessive iodine intake is frequently seen in 8-10-year-old school-age children in Hefei，but the characteristics of urinary iodine levels and thyroid autoantibodies in adult population in this area are still unclear.Objective　To investigate the characteristics of thyroid autoantibodies and influencing factors among adult population in Hefei area.Methods　A cross-sectional survey was carried out in a cluster sample of 2 593 permanent residents aged over 18 years who lived in Baohe District，Hefei for at least 6 months and were eligible for the study during January to February 2017.Physical parameters such as height，body weight，waist circumference，systolic blood pressure，and diastolic blood pressure were measured，and body mass index was calculated.Laboratory parameters such as fasting plasma glucose，2-hour postprandial plasma glucose，triacylglycerol，total cholesterol，high-density lipoprotein cholesterol，low-density lipoprotein cholesterol，glycated hemoglobin，thyroid-stimulating hormone（TSH），thyroid peroxidase antibody（TPOAb），thyroglobulin antibody（TgAb），urinary iodine，thyroid volume（TV） were also measured.According to the TPOAb and TgAb levels，they were divided into autoantibody double-positive group（both TPOAb and TgAb were positive，n=177），autoantibody single-positive group（positive TPOAb with negative TgAb or negative TPOAb with positive TgAb，n=231），and autoantibody double-negative group（both TPOAb and TgAb were negative，n=2 185）．The rate of positive thyroid autoantibodies in the participants was analyzed by sex and age.And physical and laboratory parameters were compared by both TPOAb and TgAb levels.Multivariate Logistic regression analysis was used to investigate the influencing factors for positive thyroid autoantibodies.Results　The prevalence of positive TPOAb，positive TgAb，positive TPOAb and TgAb，positive TPOAb with negative TgAb or negative TPOAb with positive TgAb，and negative TPOAb and TgAb was 9.6%（248/2 593），11.8%（307/2 593），6.8%（177/2 593），8.9%（231/2 593），84.3%（2 185/2 593），respectively.Females had higher prevalence of positive TPOAb and TgAb compared with males（P<0.05）．Females had higher percentages than males in autoantibody double-positive group and autoantibody single-positive group（P<0.001），but had lower percentage than males in autoantibody double-negative group（P=0.002）．Autoantibody single-positive group had a greater average age than autoantibody double-negative group（P=0.001）．Autoantibody double-positive group had higher average TSH and TV levels than other two groups（P<0.05）．The TSH levels and TV in autoantibody single-positive group were significantly higher than those of autoantibody double-negative group（P<0.05）．Multivariate Logistic regression analysis showed that sex，TSH levels，and TV were influencing factors for positive thyroid autoantibodies（P<0.05）．Conclusion　The median urinary iodine for adults in Hefei was 208.59μg/L，indicating that most of them took too much iodine.The prevalence of positive thyroid autoantibody，positive TPOAb，and positive TgAb was 29.4%，9.6% and 13.0%，respectively in adults in this area，which basically coincide with those of the adult populations in central and eastern of China.Females were associated with higher prevalence of positive TPOAb，and positive TgAb.Sex，TSH and TV were the influencing factors of positive thyroid autoantibody.

Key words: Thyroid diseases, Thyrotropin, Thyroid autoantibodies, Urinary iodine, Thyroid volume, Hefei