关键词: 失眠症, 睡眠障碍, 氧化性应激, 病例对照研究

Abstract: Background　Studies show that cerebral free radicals accumulate during daytime wakefulness and are removed during sleep. The removal of excess free radicals during sleep is fulfilled by reducing the production of free radicals and increasing the efficiency of endogenous antioxidant mechanisms. However, the relationship between oxidative stress and insomnia is unclear yet.Objective　To examine the levels of free radicals and antioxidant enzymes in patients with nonorganic insomnia, and to evaluate whether they have a correlation with nonorganic insomnia.Methods　This study was implemented from January 2015 to March 2017，following a case-control design.From Sleep Disorders Department，Xinjiang Mental Health Center，78 inpatients and outpatients with nonorganic insomnia〔diagnosed in accordance with the corresponding criteria included in ICD-10，in combination with Pittsburgh Sleep Quality Index （PSQI） total score ≥7 〕 were invited，and other 76 healthy workers of this hospital were invited as the controls.The plasma levels of catalase （CAT），glutathione peroxidase （GSH-PX），malondialdehyde （MDA） and superoxide dismutase （SOD） were compared between the two groups.Results　There were no significant differences in the distribution of age and sex，prevalence of smoking and drinking between the two groups （P>0.05）．The nonorganic insomnia group had higher PSQI total score and factor scores than the control group （P<0.001）．The levels of CAT，GSH-PX，and SOD activity of the nonorganic insomnia group were lower than those of the control group（P<0.001），but the level of MDA activity was similar in both groups（P>0.05）.Conclusion　Nonorganic insomnia patients have increased oxidative stress level，suggesting that oxidative stress may be involved in the development of nonorganic insomnia.

Key words: Insomnia, Sleep disorders, Oxidative stress, Case-control studies