中性粒细胞明胶酶相关脂质运载蛋白在冠心病中的研究进展

doi:10.12114/j.issn.1007-9572.2020.00.096

中国全科医学 ›› 2020, Vol. 23 ›› Issue (27): 3492-3495.DOI: 10.12114/j.issn.1007-9572.2020.00.096

中性粒细胞明胶酶相关脂质运载蛋白在冠心病中的研究进展

崔小豪1，杨志明2*

1.030001山西省太原市，山西医科大学
2.030001山西省太原市，山西医科大学第二医院心内科
*通信作者：杨志明，主任医师，博士生导师；E-mail：Zhimingyang800@sina.com

出版日期:2020-09-20 发布日期:2020-09-20

Research Progress of Neutrophil Gelatinase-associated Lipocalin in Coronary Heart Disease　

CUI Xiaohao1，YANG Zhiming2*

1.Shanxi Medical University，Taiyuan 030001，China
2.Department of Cardiology，Second Hospital of Shanxi Medical University，Taiyuan 030001，China
*Corresponding author：YANG Zhiming，Chief physician，Doctoral supervisor；E-mail：Zhimingyang800@sina.com

Published:2020-09-20 Online:2020-09-20

摘要/Abstract

摘要： 近年来心脏标志物领域有了飞速的发展，推动了整体心血管疾病诊断水平的提高。研究表明，中性粒细胞明胶酶相关脂质运载蛋白（NGAL）作为急性肾损伤（AKI）的一种标志物，与冠心病患者疾病的严重程度、不良预后及未来心血管事件的发生相关，是冠心病领域的潜力标志物。本文就NGAL的来源与性质及NGAL与冠状动脉病变严重程度、稳定型冠心病、急性冠脉综合征（ACS）、未来冠心病事件的关系的研究进展做一综述，希望能够为冠心病生物标志物领域的研究提供新的参考方向。

关键词: 冠心病, 中性粒细胞明胶酶相关脂质运载蛋白, 生物标志物, 冠状动脉病变, 稳定型冠心病, 急性冠脉综合征, 未来冠心病事件

Abstract: In recent years，the rapid development of cardiac markers has improved the overall level of cardiovascular disease's diagnosis.Research findings have shown that neutrophil gelatinase-associated lipocalin（NGAL），as a marker of acute renal injury（AKI），is closely related to the severity of coronary heart disease，adverse prognosis and the occurrence of future cardiovascular events.NGAL is also a potential marker in coronary heart disease.The purpose of this review is to elucidate the origin and nature of NGAL and the relationship between NGAL and the severity of coronary artery disease，stable coronary heart disease，acute coronary syndrome（ACS）and future coronary heart disease events.And it aims to provide a promising reference direction for the researches of biomarkers in coronary heart disease.

Key words: Coronary disease, Neutrophil gelatinase-associated lipocalin, Biomarkers, Coronary artery disease, Stable coronary heart disease, Acute coronary syndrome, Future coronary heart disease events

崔小豪,杨志明. 中性粒细胞明胶酶相关脂质运载蛋白在冠心病中的研究进展[J]. 中国全科医学, 2020, 23(27): 3492-3495. DOI: 10.12114/j.issn.1007-9572.2020.00.096.
CUI Xiaohao,YANG Zhiming. Research Progress of Neutrophil Gelatinase-associated Lipocalin in Coronary Heart Disease　[J]. Chinese General Practice, 2020, 23(27): 3492-3495. DOI: 10.12114/j.issn.1007-9572.2020.00.096.

参考文献

［1］PIEPOLI M F，CORRà U，DENDALE P，et al．Challenges in secondary prevention after acute myocardial infarction：a call for action［J］．Eur J Cardiovasc Nurs，2017，16（5）：369-380．DOI：10.1177/1474515117702594.
［2］KHAWAJA S，JAFRI L，SIDDIQUI I，et al．The utility of neutrophil gelatinase-associated Lipocalin（NGAL）as a marker of acute kidney injury（AKI）in critically ill patients［J］．Biomark Res，2019，7：4．DOI：10.1186/s40364-019-0155-1.
［3］KJELDSEN L，JOHNSEN A H，SENGEL?V H，et al．Isolation and primary structure of NGAL，a novel protein associated with human neutrophil gelatinase［J］．J Biol Chem，1993，268（14）：10425-10432.
［4］PEDERSEN K R，RAVN H B，HJORTDAL V E，et al．Neutrophil gelatinase-associated lipocalin（NGAL）：validation of commercially available ELISA［J］．Scand J Clin Lab Invest，2010，70（5）：374-382．DOI：10.3109/00365513.2010.486868.
［5］HELANOVA K，SPINAR J，PARENICA J.Diagnostic and prognostic utility of neutrophil gelatinase-associated lipocalin（NGAL）in patients with cardiovascular diseases——review［J］．Kidney Blood Press Res，2014，39（6）：623-629．DOI：10.1159/000368474.
［6］PRECEK J，HUTYRA M，KOVáCIK F，et al．Biomarkers of renal function in prognostic stratification of patients with acute coronary syndrome［J］．Cor Vasa，2018，60（2）：e148-154．DOI：10.1016/j.crvasa.2017.05.018.
［7］HEMDAHL A L，GABRIELSEN A，ZHU C Y，et al．Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction［J］．Arterioscler Thromb Vasc Biol，2006，26（1）：136-142．DOI：10.1161/01.ATV.0000193567.88685.f4.
［8］EILENBERG W，STOJKOVIC S，PIECHOTA-POLANCZYK A，et al．Neutrophil gelatinase-associated lipocalin（NGAL）is associated with symptomatic carotid atherosclerosis and drives pro-inflammatory state in vitro［J］．Eur J Vasc Endovasc Surg，2016，51（5）：623-631．DOI：10.1016/j.ejvs.2016.01.009.
［9］SUNG H K，CHAN Y K，HAN M，et al．Lipocalin-2（NGAL）attenuates autophagy to exacerbate cardiac apoptosis induced by myocardial ischemia［J］．J Cell Physiol，2017，232（8）：2125-2134．DOI：10.1002/jcp.25672.
［10］ZOGRAFOS T，HALIASSOS A，KOROVESIS S，et al．Association of neutrophil gelatinase-associated lipocalin with the severity of coronary artery disease［J］．Am J Cardiol，2009，104（7）：917-920．DOI：10.1016/j.amjcard.2009.05.023.
［11］SOYLU K，AKSAN G，NAR G，et al．Serum neutrophil gelatinase-associated lipocalin levels are correlated with the complexity and the severity of atherosclerosis in acute coronary syndrome［J］．Anatol J Cardiol，2015，15（6）：450-455．DOI：10.5152/akd.2014.5513.
［12］KATAGIRI M，TAKAHASHI M，DOI K，et al．Serum neutrophil gelatinase-associated lipocalin concentration reflects severity of coronary artery disease in patients without heart failure and chronic kidney disease［J］．Heart Vessels，2016，31（10）：1595-1602．DOI：10.1007/s00380-015-0776-8.
［13］李超，彭瑜，高涵翔，等．血浆中性粒细胞明胶酶相关脂质运载蛋白水平与急性ST段抬高型心肌梗死病变严重程度的关系［J］．中国循环杂志，2018，33（3）：222-226．DOI：10.3969/j.issn.1000-3614.2018.03.004.
LI C，PENG Y，GAO H X，et al．Relationship between plasma level of neutrophil gelatinase-associated lipocalin and coronary lesion severity in patients with acute ST-elevation myocardial infarction［J］．Chinese Circulation Journal，2018，33（3）：222-226．DOI：10.3969/j.issn.1000-3614.2018.03.004.
［14］MALYSZKO J，BACHORZEWSKA-GAJEWSKA H，MALYSZKO J S，et al．Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in hypertensive and normotensive patients with coronary artery disease［J］．Nephrology（Carlton），2008，13（2）：153-156．DOI：10.1111/j.1440-1797.2007.00899.x.
［15］PAULSSON J，DADFAR E，HELD C，et al．Activation of peripheral and in vivo transmigrated neutrophils in patients with stable coronary artery disease［J］．Atherosclerosis，2007，192（2）：328-334．DOI：10.1016/j.atherosclerosis.2006.08.003.
［16］CHAKRABARTI S，PATEL K D.Regulation of matrix metalloproteinase-9 release from IL-8-stimulated human neutrophils［J］．J Leukoc Biol，2005，78（1）：279-288．DOI：10.1189/jlb.1004612.
［17］SIVALINGAM Z，ERIK MAGNUSSON N，GROVE E L，et al．Neutrophil gelatinase-associated lipocalin（NGAL）and cardiovascular events in patients with stable coronary artery disease［J］．Scand J Clin Lab Invest，2018，78（6）：470-476．DOI：10.1080/00365513.2018.1499956.
［18］LINDBERG S，PEDERSEN S H，MOGELVANG R，et al．Prognostic utility of neutrophil gelatinase-associated lipocalin in predicting mortality and cardiovascular events in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention［J］．J Am Coll Cardiol，2012，60（4）：339-345．DOI：10.1016/j.jacc.2012.04.017.
［19］ZYKOV M V，KASHTALAP V V，BYKOVA I S，et al．Clinical and prognostic value of serum neutrophil gelatinase-associated lipocalin in patients with ST-segment elevation myocardial infarction［J］．Kardiologiia，2016，56（5）：24-29．DOI：10.18565/cardio.2016.5.24-29.
［20］LIM Y M，MOON J Y，MIN D，et al．Serial measurements of neutrophil gelatinase-associated lipocalin：prognostic value in patients with ST-segment elevation myocardial infarction treated with a primary percutaneous coronary intervention［J］．Coron Artery Dis，2017，28（8）：690-696．DOI：10.1097/MCA.0000000000000542.
［21］FAN Y，ZOU C.Prognostic value of neutrophil gelatinase-associated lipocalin in patients with acute ST-segment elevation myocardial infarction：a meta-analysis［J］．Eur J Prev Cardiol，2019，26（4）：444-446．DOI：10.1177/2047487318783254.
［22］NYMO S H，HARTFORD M，UELAND T，et al．Serum neutrophil gelatinase-associated lipocalin（NGAL）concentration is independently associated with mortality in patients with acute coronary syndrome［J］．Int J Cardiol，2018，262：79-84．DOI：10.1016/j.ijcard.2018.03.028.
［23］LAHIRI A，ALEX A G，GEORGE P V.Estimating the prevalence of elevated plasma neutrophil gelatinase associated lipocalin level in patients with acute coronary syndromes and its association with outcomes［J］．Indian Heart J，2018，70（2）：220-224．DOI：10.1016/j.ihj.2017.06.005.
［24］SHALENKOVA M A，MIKHAILOVA Z D，KLIMKIN P F.NGAL as a marker for some extrarenal complications in acute coronary syndrome［J］．Kardiologiia，2018（S3）：19-26.
［25］MARTíNEZ-MARTíNEZ E，BUONAFINE M，BOUKHALFA I，et al．Aldosterone target NGAL（neutrophil gelatinase-associated lipocalin）is involved in cardiac remodeling after myocardial infarction through NFκB pathway［J］．Hypertension，2017，70（6）：1148-1156．DOI：10.1161/HYPERTENSIONAHA.117.09791.
［26］NAKA K K，PAPATHANASSIOU K，BECHLIOULIS A，et al．Association of vascular indices with novel circulating biomarkers as prognostic factors for cardiovascular complications in patients with type 2 diabetes mellitus［J］．Clin Biochem，2018，53：31-37．DOI：10.1016/j.clinbiochem.2017.12.010.
［27］CHONG J J H，PRINCE R L，THOMPSON P L，et al．Association between plasma neutrophil gelatinase-associated lipocalin and cardiac disease hospitalizations and deaths in older women［J］．J Am Heart Assoc，2019，8（1）：e011028．DOI：10.1161/JAHA.118.011028.
［28］FASSETT R G，ROBERTSON I K，BALL M J，et al．Effects of atorvastatin on NGAL and cystatin C in chronic kidney disease：a post hoc analysis of the LORD trial［J］．Nephrol Dial Transplant，2012，27（1）：182-189．DOI：10.1093/ndt/gfr193.
［29］LáBR K，?PINAR J，PARENICA J，et al．Renal functions and prognosis stratification in chronic heart failure patients and the importance of neutrophil gelatinase-associated lipocalin［J］．Kidney Blood Press Res，2018，43（6）：1865-1877．DOI：10.1159/000495819.
［30］CHEN S，CHEN X C，LOU X H，et al．Determination of serum neutrophil gelatinase-associated lipocalin as a prognostic biomarker of acute spontaneous intracerebral hemorrhage［J］．Clin Chim Acta，2019，492：72-77．DOI：10.1016/j.cca.2019.02.009.
［31］MOSCHEN A R，ADOLPH T E，GERNER R R，et al．Lipocalin-2：a master mediator of intestinal and metabolic inflammation［J］．Trends Endocrinol Metab，2017，28（5）：388-397．DOI：10.1016/j.tem.2017.01.003.
［61］MATSUSHITA S，YONEKURA K，MERA K，et al．Successful treatment of metastatic extramammary Paget's disease with S-1 and docetaxel combination chemotherapy［J］．J Dermatol，2011，38（10）：996-998．DOI:10.1111/j.1346-8138.2010.01149.x.
［62］BELEZNAY K M，LEVESQUE M A，GILL S.Response to 5-fluorouracil in metastatic extramammary Paget disease of the scrotum presenting as pancytopenia and back pain［J］．Curr Oncol，2009，16（5）：81-83．DOI:10.3747/co.v16i5.374.
［63］TAKAHAGI S，NODA H，KAMEGASHIRA A，et al．Metastatic extramammary Paget's disease treated with paclitaxel and trastuzumab combination chemotherapy［J］．J Dermatol，2009，36（8）：457-461．DOI:10.1111/j.1346-8138.2009.00676.x.
［64］MOCHITOMI Y，SAKAMOTO R，GUSHI A，et al．Extramammary Paget's disease/carcinoma successfully treated with a combination chemotherapy：report of two cases［J］．J Dermatol，2005，32（8）：632-637．DOI:10.1111/j.1346-8138.2005.tb00812.x.
［65］WATANABE Y，HOSHIAI H，UEDA H，et al．Low-dose mitomycin C，etoposide，and cisplatin for invasive vulvar Paget's disease［J］．Int J Gynecol Cancer，2002，12（3）：304-307．DOI:10.1046/j.1525-1438.2002.01126.x.
［66］AL HALLAK M N，ZOUAIN N.Extramammary perianal Paget's disease［J］．Case Rep Gastroenterol，2009，3（3）：332-337．DOI:10.1159/000256382.
［67］ZOLLO J D，ZEITOUNI N C.The Roswell park cancer institute experience with extramammary Paget's disease［J］．Br J Dermatol，2000，142（1）：59-65．DOI:10.1046/j.1365-2133.2000.03242.x.
［68］YE J N，RHEW D C，YIP F，et al．Extramammary Paget's disease resistant to surgery and imiquimod monotherapy but responsive to imiquimod combination topical chemotherapy with 5-fluorouracil and retinoic acid：a case report［J］．Cutis，2006，77（4）：245-250.
［69］ITO T，KAKU Y，NAGAE K，et al．Tumor thickness as a prognostic factor in extramammary Paget's disease［J］．J Dermatol，2015，42（3）：269-275．DOI:10.1111/1346-8138.12764.
［70］KARAM A，DORIGO O.Treatment outcomes in a large cohort of patients with invasive extramammary Paget's disease［J］．Gynecol Oncol，2012，125（2）：346-351．DOI:10.1016/j.ygyno.2012.01.032.
［71］HERREL L A 1，WEISS A D，GOODMAN M，et al．Extramammary Paget's disease in males:survival outcomes in 495 patients［J］.Ann Surg Oncol，2015，22（5）:1625-1630．DOI：10.1245/s10434-014-4139-y.
［72］WANG Z，LU M，DONG G Q，et al．Penile and scrotal Paget's disease:130 Chinese patients with long-term follow-up［J］.BJU Int，2008，102（4）：485-488．DOI:10.1111/j.1464-410X.2008.07575.x.

[1]	杨玲, 杜雪平. 全科住院医师规范化培训第3年基层门诊教学实践：PQRST疼痛评估法联合心血管风险评估诊治不典型急性冠脉综合征[J]. 中国全科医学, 2026, 29(09): 1121-1128.
[2]	江晓蕊, 闫玉瑶, 卫靖靖, 乔利杰, 彭广操, 朱明军. 冠心病患者并发心力衰竭风险预测模型的系统评价[J]. 中国全科医学, 2026, 29(03): 393-402.
[3]	王学胜, 张羽松, 龚福汉, 蒋丁胜. β-原肌球蛋白在不同心肌病患者心肌组织中的表达及临床价值研究[J]. 中国全科医学, 2026, 29(03): 311-315.
[4]	张云秋, 李扬雪, 刘浩洋, 陈佩璇, 王星月, 崔敬雅. 早发冠心病患者共病情况及共病模式研究[J]. 中国全科医学, 2026, 29(02): 226-231.
[5]	范转转, 李文婷, 马国亮. 绝经后女性内脏脂肪指数与心血管疾病的关联性分析：前瞻性队列研究[J]. 中国全科医学, 2026, 29(02): 180-187.
[6]	刘燕, 袁艳玲, 令榕, 王兰云, 孙丽. 远程医疗在冠心病患者心脏康复中应用的范围综述[J]. 中国全科医学, 2025, 28(36): 4640-4647.
[7]	陈丽, 熊卫红, 路孝琴. 经皮冠状动脉介入术后患者用药依从性及影响因素研究[J]. 中国全科医学, 2025, 28(36): 4586-4591.
[8]	田佳庆, 彭鹏, 韦雨柔, 肖方骏, 何宪顺, 林锟, 陆舜, 何敏聪, 刘良燕, 魏秋实. 胱抑素A对股骨头坏死的预测价值研究[J]. 中国全科医学, 2025, 28(35): 4464-4472.
[9]	代天顾, 何清, 高雪菲, 张高钰, 樊佳溶, 王子涵, 肖响, 李琳. 肱踝脉搏波传导速度和血清总胆固醇及N末端B型脑钠肽前体联合检测对原发性高血压患者发生冠心病的预测价值研究[J]. 中国全科医学, 2025, 28(32): 4061-4066.
[10]	吴文俊, 卫靖靖, 李雪, 任红杰, 于瑞, 彭广操, 朱明军. 基于隐结构模型结合关联规则分析冠心病合并高血压的方药规律[J]. 中国全科医学, 2025, 28(30): 3787-3795.
[11]	李玲, 李雅萍, 钱时兴, 聂婧, 陆春华, 李霞. 社区中老年人认知功能影响因素及风险预测研究[J]. 中国全科医学, 2025, 28(30): 3773-3778.
[12]	周启保, 罗潇, 陈玲, 曹俊达, 李菊香, 徐劲松, 苏海. 收缩压昼夜变异率联合正常RR间期标准差对冠心病诊断价值的临床研究[J]. 中国全科医学, 2025, 28(30): 3760-3765.
[13]	农景堂, 杨成敏, 莫圣龙, 陆志成, 唐丽娜, 简崇东, 商敬伟. 脑梗死预后相关生物标志物的研究新进展：机制与临床应用[J]. 中国全科医学, 2025, 28(29): 3711-3720.
[14]	李嘉欣, 刘钟桧, 谢硕, 付志方, 孙丹, 焦红梅. 分解代谢及炎症状态的生物标志物变化趋势对老年患者慢性危重症的早期预测价值研究[J]. 中国全科医学, 2025, 28(24): 2993-2999.
[15]	杨继, 张垚, 赵英强, 张秋月. 中医三级防控模式对冠心病与脑卒中患者的管理效能评价：一项单中心前瞻性队列研究[J]. 中国全科医学, 2025, 28(22): 2750-2761.

中性粒细胞明胶酶相关脂质运载蛋白在冠心病中的研究进展

Research Progress of Neutrophil Gelatinase-associated Lipocalin in Coronary Heart Disease

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

留言