关键词: 脑梗死, 青年人, 中年人, 老年人, 危险因素, 预后

Abstract: Objective　To investigate the risk factors，etiological type and prognosis of pontine infarction patients of different age groups.Methods　We enrolled 74 pontion infarction patients from Department of Neurology，Beijing Zhongguancun Hospital from March 2015 to March 2017 and assigned 37 younger than 65 years old of them to the young-to-middle-aged group，and other 37 aged ≥65 to elderly group，respectively.We collected and analyzed their baseline characteristics，such as demographic data，past medical history，laboratory findings and imaging findings as well as modified Rankin Scale （mRS） score.Results　Compared with the young-to-middle-aged group，elderly group demonstrated higher percentage of patients with diabetes but lower percentage of patients with hyperlipidemia（P<0.05）.Moreover，elderly patients were found with higher levels of mean glycosylated hemoglobin and systolic pressure and lower level of mean triacylglycerol（P<0.05）.Two groups presented no significant differences in types of etiology for pontine infarction（χ2=2.303，P=0.316）.To be specific，young-to-middle-aged group and elderly group showed similar prevalence of large-artery-occlusive disease-related pontine infarction〔5.4%（2/37） vs.16.2%（6/37）〕，similar prevalence of basilar artery branch disease related-pontine infarction〔45.9%（17/37） vs.43.3%（16/37）〕 and similar prevalence of small vessel disease-related pontine infarction〔48.7% （18/37） vs.40.5% （15/37）〕.Young-to-middle-aged group and elderly group also presented similar rate of poor short-term prognosis〔27.0% （10/37） vs.29.7% （11/37）〕（χ2=0.111，P>0.05）.Conclusion　Hypertension，hyperlipidemia，and history of smoking and drinking were major risk factors for pontion infarction in young-to-middle-aged people，while diabetes was the major risk factor for pontion infarction in elderly people.Pontion infarction in young-to-middle-aged people was mainly due to small vessel disease，whereas that in elderly people was mainly due to basilar artery branch disease.Poor short-term prognosis was found in 1/3 of the young-to-middle-aged patients and elderly patients with pontion infarction.

Key words: Brain infarction, Young adult, Middle aged, Aged, Risk factors, Prognosis