新疆地区2型糖尿病患者合并亚临床甲状腺功能减退症情况及影响因素研究

doi:10.3969/j.issn.1007-9572.2016.28.014

摘要/Abstract

摘要： 目的　了解新疆地区2型糖尿病（T2DM）患者合并亚临床甲状腺功能减退症（甲减）的情况，并探讨其影响因素。方法　选取2013年1月—2014年12月到新疆医科大学第一附属医院就诊的T2DM患者444例。回顾性分析其基本情况和实验室检测指标，采用Logistic逐步回归分析探讨T2DM患者合并亚临床甲减的影响因素。结果　共73例患者（16.4%）合并亚临床甲减，维吾尔族患者的亚临床甲减合并率（27.4%，52/190）高于汉族（8.3%，21/254），差异有统计学意义（P0.05）；合并亚临床甲减患者的维吾尔族比例、收缩压、舒张压高于未合并患者，血肌酐（SCr）低于未合并者，差异有统计学意义（P<0.05）。多元Logistic逐步回归分析结果显示，民族、收缩压、舒张压、尿酸、SCr对T2DM患者合并亚临床甲减的影响有统计学意义（P<0.05）。结论　新疆地区T2DM患者的亚临床甲减合并率较高，且维吾尔族高于汉族。民族、收缩压、舒张压、尿酸、SCr是其影响因素。

关键词: 糖尿病, 2型, 甲状腺功能减退症, 影响因素分析, 新疆［维吾尔自治区］

Abstract: Objective　To understand status of type 2 diabetic mellitus（T2DM） patients combined with subclinical hypothyroidism in Xinjiang,and to investigate its influencing factors.Methods　444 patients with T2DM who received treatment in the First Affiliated Hospital of Xinjiang Medical University from January 2013 to December 2014 were collected.Basic situation and laboratory test indicators were retrospectively analyzed,and influencing factors of T2DM patients combined with subclinical hypothyroidism were discussed by Logistic regression analysis.Results　There were 73 patients（16.4%） combined with subclinical hypothyroidism,the combining rate of subclinical hypothyroidism of Uygur patients（27.4%,52/190） was significantly higher than that of the Han nationality（8.3%,21/254,P<0.05）.The comparison of gender,average age,BMI,glycated hemoglobin（HbA1c）,total cholesterol（TC）,triglyceride（TG）,low density lipoprotein cholesterol（LDL-C）,high density lipoprotein cholesterol（HDL-C）,uric acid,ALT,anti-thyroglobulin antibody（TGAb） and thyroid peroxidase antibody（TPOAb） between patients combined with or without subclinical hypothyroidism was not significantly different（P>0.05）;the comparison of Uygur proportion,systolic blood pressure and diastolic blood pressure of patients combined with subclinical hypothyroidism was significantly higher than that of patients combined without subclinical hypothyroidism,the comparison of serum creatinine（SCr） of patients combined with subclinical hypothyroidism was significantly lower than that of patients combined without subclinical hypothyroidism（P<0.05）.Multiple Logistic stepwise regression analysis showed that nationality,systolic blood pressure,diastolic blood pressure,uric acid,SCr significantly influenced T2DM patients combined with subclinical hypothyroidism（P<0.05）.Conclusion　The combining rate of subclinical hypothyroidism of T2DM patients in Xinjiang is rather high,and the rate of Uygur is higher than that of the Han nationality.The influencing factors are nationality,systolic blood pressure,diastolic blood pressure,uric acid and SCr.

Key words: Diabetes mellitus,type 2, Hypothyroidism, Root cause analysis, Xinjiang

唐若曦, 樊勇. 新疆地区2型糖尿病患者合并亚临床甲状腺功能减退症情况及影响因素研究[J]. 中国全科医学, 2016, 19(28): 3452-3456.

TANG Ruo-xi, FAN Yong. Status and Influencing Factors of Type 2 Diabetic Mellitus Patients Combined with Subclinical Hypothyroidism in Xinjiang[J]. Chinese General Practice, 2016, 19(28): 3452-3456.

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