关键词: 肾透析, 营养不良-炎性反应综合征, 生活质量

Abstract: Objective　To explore the influence of malnutrition-inflammatory complex syndrome（MICS）on the quality of life of patients with maintenance hemodialysis（MHD）.Methods　The research samples,70 patients who received MHD in the First Affiliated Hospital of Kunming Medical University and Yunnan Kidney Disease Hospital from October 2014 to December 2015 were selected.According to scores of malnutrition-inflammation（MIS）,patients were separated into 3 groups,involving mild group（n=19）,moderate group（n=29）,and severe group（n=22）.The nutrition and inflammatory index of patients in three groups were detected,and short form health survey questionnaire（SF-36） was used to evaluate their quality of life,and the correlations between MIS and patients’ age,nutrition and inflammatory index,and SF-36 scores were investigated.Results　The incidence rate of included patients was 100.0%,average MIS scores of patients in mild,moderate and severe group were（2.7±1.0）,（6.1±0.9）,and（10.9±2.2）.There was significant difference in grip strength,serum ferritin（SF）,high-sensitivity C-reactive protein（hs-CRP）,and tumor necrosis factor α（TNF-α） among patients in 3 groups（P<0.05）;while there was no significant difference in prealbumin（PA） and interleukin-6（IL-6,P>0.05）.Pearson correlation analysis showed that there was a linearly positive correlation between MIS and age,TNF-α（P<0.05）,there was a linearly negative correlation between MIS and grip strength（P<0.05）,and MIS and PA showed no linearly correlation（P>0.05）;Spearman rank correlation analysis presented that MIS was positive correlated with SF and hs-CRP（P<0.05）,and not correlated with IL-6（P>0.05）.There was significant difference in scores of role physical（RP） and total scores of the scale among patients in three groups（P<0.05）;While there was no significant difference in scores of physical function（PF）,body pain（BP）,general health（GH）,energy state（Energy）,social function（SOCF）,role emotional（RE）,emotion well-being（EWB） and physical health（PH）,mental health（MH） score（P>0.05）.Pearson correlation analysis showed that MIS was linearly negatively correlated with PH scores（P<0.05）,and was not linearly correlated with scores of GH and Energy（P>0.05）;Spearman rank correlation analysis manifested that MIS was negatively correlated with PF,RP and total scores of scale（P<0.05）,and was not correlated with scores of BP,SOCF,RE,EWB and MH（P>0.05）.Conclusion　The incidence rate of MICS of MHD patients is high,the more severe MICS is,the more obvious grip strength reduces,the more severe inflammatory state is,the worse overall quality of life is.

Key words: Renal dialysis, Malnutrition-inflammation complex syndrome, Quality of life