关键词: 克罗恩病, 早期诊断, 病理生理学, 流行病学, 疾病管理, 治疗学

Abstract: Crohn's disease(CD) is a chronic immune-mediated inflammatory disorder affecting the gastrointestinal tract. Due to the absence of specific clinical manifestations in the early stages of CD, its identification and diagnosis present significant challenges, often resulting in diagnostic delays. By the time a diagnosis is made, related complications typically have developed, complicating the potential for a cure. This review examines the natural history, definition, pathophysiology, epidemiological characteristics, and management strategies of early CD. It underscores the necessity of employing effective screening tools, risk stratification based on disease severity, and the implementing of opportunistic screening strategies. Close monitoring and follow-up should be conducted for high-risk populations, utilizing genetic testing, specific serum biomarkers, gut microbiota analysis, imaging, and endoscopic techniques. The "golden window of opportunity" should be capitalized upon for early, appropriate, and adequate intervention, thereby providing novel strategies and guidance for the diagnosis and treatment of this disease.

Key words: Crohn's disease, Early diagnosis, Pathophysiology, Epidemiology, Disease management, Therapeutics