中国全科医学 ›› 2021, Vol. 24 ›› Issue (9): 1165-1172.DOI: 10.12114/j.issn.1007-9572.2021.00.003
• 专题研究 • 上一篇
肖锶瑶1,张纾难2*
出版日期:
2021-03-20
发布日期:
2021-03-20
XIAO Siyao1,ZHANG Shunan2*
Published:
2021-03-20
Online:
2021-03-20
摘要: 肠道菌群是定植在肠道内的庞大微生物群落。研究表明,肠道菌群在生物体内的新陈代谢、免疫系统发育、炎性反应等方面发挥着重要作用,与消化系统、免疫系统、神经系统、呼吸系统等疾病密切相关。随着微生物分析技术的发展,肠道菌群与呼吸系统疾病之间的关系受到越来越多的关注和重视,“肠-肺轴”的提出更为呼吸系统疾病的发病机制研究和治疗手段提供了新的思路。本文综述了肠道和呼吸道菌群的相关性以及与肠-肺轴之间的交互作用,重点介绍了肠道菌群与呼吸道感染性疾病、气道过敏性疾病、慢性阻塞性肺疾病、囊性纤维化、肺结核、肺癌等呼吸系统疾病之间的关系和作用机制,以期为呼吸系统疾病的发病机制研究和治疗提供新的思路。
[1]MOELLER A H,LI Y,NGOLE E M,et al.Rapid changes in the gut microbiome during human evolution[J].PNAS,2014,111(46):16431-16435.DOI:10.1073/pnas.1419136111.
[2]GOODRICH J K,WATERS J L,POOLE A C,et al.Human genetics shape the gut microbiome[J].Cell,2014,159(4):789-799.DOI:10.1016/j.cell.2014.09.053. [3]B?UMLER A J,SPERANDIO V.Interactions between the microbiota and pathogenic bacteria in the gut[J].Nature,2016,535(7610):85-93.DOI:10.1038/nature18849. [4]LYNCH S V,PEDERSEN O.The human intestinal microbiome in health and disease[J].N Engl J Med,2016,375(24):2369-2379.DOI:10.1056/nejmra1600266. [5]MCALEER J P,KOLLS J K.Contributions of the intestinal microbiome in lung immunity[J].Eur J Immunol,2018,48(1):39-49.DOI:10.1002/eji.201646721. [6]FOSTER J A,MCVEY NEUFELD K A.Gut-brain axis:how the microbiome influences anxiety and depression[J].Trends Neurosci,2013,36(5):305-312.DOI:10.1016/j.tins.2013.01.005. [7]DELZENNE N M,KNUDSEN C,BEAUMONT M,et al.Contribution of the gut microbiota to the regulation of host metabolism and energy balance:a focus on the gut–liver axis[J].Proc Nutr Soc,2019,78(3):319-328.DOI:10.1017/s0029665118002756. [8]SAMUELSON D R,CHARLES T P,DE LA RUA N M,et al.Analysis of the intestinal microbial community and inferred functional capacities during the host response to Pneumocystis pneumonia[J].Exp Lung Res,2016,42(8/9/10):425-439.DOI:10.1080/01902148.2016.1258442. [9]SEKIROV I,RUSSELL S L,ANTUNES L C M,et al.Gut microbiota in health and disease[J].Physiol Rev,2010,90(3):859-904.DOI:10.1152/physrev.00045.2009. [10]VUTCOVICI M,BITTON A,ERNST P,et al.Inflammatory bowel disease and risk of mortality in COPD[J].Eur Respir J,2016,47(5):1357-1364.DOI:10.1183/13993003.01945-2015. [11]BELKACEM N,BOURDET-SICARD R,TAHA M K.Lactobacillus paracasei feeding improves the control of secondary experimental meningococcal infection in flu-infected mice[J].BMC Infect Dis,2018,18(1):1-9.DOI:10.1186/s12879-018-3086-9. [12]WYPYCH T P,MARSLAND B J.Diet hypotheses in light of the microbiota revolution:new perspectives[J].Nutrients,2017,9(6):537.DOI:10.3390/nu9060537. [13]B?CKHED F,ROSWALL J,PENG Y,et al.Dynamics and stabilization of the human gut microbiome during the first year of life[J].Cell Host Microbe,2015,17(5):690-703.DOI:10.1016/j.chom.2015.04.004. [14]YALLAPRAGADA S G,NASH C B,ROBINSON D T.Early-life exposure to antibiotics,alterations in the intestinal microbiome,and risk of metabolic disease in children and adults[J].Pediatr Ann,2015,44(11):e265-269.DOI:10.3928/00904481-20151112-09. [15]FUJIMURA K E,DEMOOR T,RAUCH M,et al.House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection[J].PNAS,2014,111(2):805-810.DOI:10.1073/pnas.1310750111. [16]BIRCHENOUGH G M H,NYSTROM E E L,JOHANSSON M E V,et al.A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion[J].Science,2016,352(6293):1535-1542.DOI:10.1126/science.aaf7419. [17]KNOOP K A,GUSTAFSSON J K,MCDONALD K G,et al.Antibiotics promote the sampling of luminal antigens and bacteria via colonic goblet cell associated antigen passages[J].Gut Microbes,2017,8(4):400-411.DOI:10.1080/19490976.2017.1299846. [18]TAN J,MCKENZIE C,POTAMITIS M,et al.The role of short-chain fatty acids in health and disease[J].Adv Immunol,2014,121:91-119.DOI:10.1016/b978-0-12-800100-4.00003-9. [19]CHELLAPPAN D K,SZE NING Q L,SU MIN S K,et al.Interactions between microbiome and lungs:paving new paths for microbiome based bio-engineered drug delivery systems in chronic respiratory diseases[J].Chem Biol Interact,2019,310:108732.DOI:10.1016/j.cbi.2019.108732. [20]MASCHIROW L,SUTTORP N,OPITZ B.Microbiota-dependent regulation of antimicrobial immunity in the lung[J].Am J Respir Cell Mol Biol,2019,61(3):284-289.DOI:10.1165/rcmb.2019-0101tr. [21]BARCIK W,BOUTIN R C T,SOKOLOWSKA M,et al.The role of lung and gut microbiota in the pathology of asthma[J].Immunity,2020,52(2):241-255.DOI:10.1016/j.immuni.2020.01.007. [22]HE Y,WEN Q,YAO F,et al.Gut-lung axis:the microbial contributions and clinical implications[J].Crit Rev Microbiol,2017,43(1):81-95.DOI:10.1080/1040841x.2016.1176988. [23]ZHENG X L,YANG Y,WANG B J,et al.Synchronous dynamic research on respiratory and intestinal microflora of chronic bronchitis rat model[J].Chin J Integr Med,2017,23(3):196-200.DOI:10.1007/s11655-016-2731-7. [24]DICKSON R P,SCHULTZ M J,VAN DER POLL T,et al.Lung microbiota predict clinical outcomes in critically ill patients[J].Am J Respir Crit Care Med,2020,201(5):555-563.DOI:10.1164/rccm.201907-1487oc. [25]GAUGUET S,D'ORTONA S,AHNGER-PIER K,et al.Intestinal microbiota of mice influences resistance to staphylococcus aureus pneumonia[J].Infect Immun,2015,83(10):4003-4014.DOI:10.1128/iai.00037-15. [26]MCALEER J P,NGUYEN N L,CHEN K,et al.Pulmonary Th17 antifungal immunity is regulated by the gut microbiome[J].J Immunol,2016,197(1):97-107.DOI:10.4049/jimmunol.1502566. [27]VAREILLE-DELARBRE M,MIQUEL S,GARCIN S,et al.Immunomodulatory effects of lactobacillus plantarum on inflammatory response induced by klebsiella pneumoniae[J].Infect Immun,2019,87(11).DOI:10.1128/iai.00570-19. [28]TENG F,KLINGER C N,FELIX K M,et al.Gut microbiota drive autoimmune arthritis by promoting differentiation and migration of peyer's patch T follicular helper cells[J].Immunity,2016,44(4):875-888.DOI:10.1016/j.immuni.2016.03.013. [29]GROVES H T,CUTHBERTSON L,JAMES P,et al.Respiratory disease following viral lung infection alters the murine gut microbiota[J].Front Immunol,2018,9:182.DOI:10.3389/fimmu.2018.00182. [30]LANKELMA J M,BIRNIE E,WEEHUIZEN T A F,et al.The gut microbiota as a modulator of innate immunity during melioidosis[J].PLoS Negl Trop Dis,2017,11(4):e0005548.DOI:10.1371/journal.pntd.0005548. [31]谢青梅,陆浩然,张露萱,等.H9N2 AIV对小鼠肠道菌群结构及黏膜屏障功能的影响研究[J].中国家禽,2017,39(20):18-22.DOI:10.16372/j.issn.1004-6364.2017.20.004. [32]何玉姝,李慧玲,王瑾,等.肠道微生态变化与小儿反复呼吸道感染的相关研究[J].世界最新医学信息文摘:连续型电子期刊,2019,19(7):107-108.DOI:10.19613/j.cnki.1671-3141.2019.07.074. [33]曾芜薇,余斓,丁伟艳,等.抗生素诱导的肠道菌群失调加重小鼠肺炎支原体感染[J].中华微生物学和免疫学杂志,2020,40(1):68-73.DOI:10.3760/cma.j.issn.0254-5101.2020.01.012. [34]郭宏伟,张妮妮,张伟,等.抗生素诱导的菌群紊乱对幼鼠结肠黏膜屏障及免疫反应的影响[J].中华实用儿科临床杂志,2019,34(7):505-509.DOI:10.3760/cma.j.issn.2095-428X.2019.07.007. GUO H W,ZHANG N N,ZHANG W,et al.Effect of antibiotic-induced microbiota dysbiosis on colonic mucosal barrier and immune response in juvenile mice[J].Chinese Journal of Applied Clinical Pediatrics,2019,34(7):505-509.DOI:10.3760/cma.j.issn.2095-428X.2019.07.007. [35]FELIX K M,JAIMEZ I A,NGUYEN T V,et al.Gut microbiota contributes to resistance against pneumococcal pneumonia in immunodeficient rag(-/-) mice[J].Front Cell Infect Microbiol,2018,8:118.DOI:10.3389/fcimb.2018.00118. [36]YITBAREK A,ALKIE T,TAHA-ABDELAZIZ K,et al.Gut microbiota modulates type I interferon and antibody-mediated immune responses in chickens infected with influenza virus subtype H9N2[J].Benef Microbes,2018,9(3):417-427.DOI:10.3920/bm2017.0088. [37]LI B,YIN G F,WANG Y L,et al.Impact of fecal microbiota transplantation on TGF-β1/Smads/ERK signaling pathway of endotoxic acute lung injury in rats[J].Biotech,2020,10(2):52.DOI:10.1007/s13205-020-2062-4. [38]COSTA M C,SANTOS J R,RIBEIRO M J,et al.The absence of microbiota delays the inflammatory response to Cryptococcus gattii[J].Int J Med Microbiol,2016,306(4):187-195.DOI:10.1016/j.ijmm.2016.03.010. [39]SCHUIJT T J,LANKELMA J M,SCICLUNA B P,et al.The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia[J].Gut,2016,65(4):575-583.DOI:10.1136/gutjnl-2015-309728. [40]NIE X,LI L,YI M,et al.The intestinal microbiota plays as a protective regulator against radiation pneumonitis[J].Radiat Res,2020,194(1):52-60.DOI:10.1667/rr15579.1. [41]FANGOUS M S,ALEXANDRE Y,HYMERY N,et al.Lactobacilli intra-tracheal administration protects from Pseudomonas aeruginosa pulmonary infection in mice——a proof of concept[J].Benef Microbes,2019,10(8):893-900.DOI:10.3920/bm2019.0069. [42]STEED A L,CHRISTOPHI G P,KAIKO G E,et al.The microbial metabolite desaminotyrosine protects from influenza through type I interferon[J].Science,2017,357(6350):498-502.DOI:10.1126/science.aam5336. [43]CHAN C K Y,TAO J,CHAN O S,et al.Preventing respiratory tract infections by synbiotic interventions:a systematic review and meta-analysis of randomized controlled trials[J].Adv Nutr,2020,11(4):979-988.DOI:10.1093/advances/nmaa003. [44]BARFOD K K,ROGGENBUCK M,AL-SHUWELI S,et al.Alterations of the murine gut microbiome in allergic airway disease are independent of surfactant protein D[J].Heliyon,2017,3(3):e00262.DOI:10.1016/j.heliyon.2017.e00262. [45]VITAL M,HARKEMA J R,RIZZO M,et al.Alterations of the murine gut microbiome with age and allergic airway disease[J].J Immunol Res,2015,2015:1-8.DOI:10.1155/2015/892568. [46]MICHALOVICH D,RODRIGUEZ-PEREZ N,SMOLINSKA S,et al.Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients[J].Nat Commun,2019,10(1):5711.DOI:10.1038/s41467-019-13751-9. [47]BUENDíA E,ZAKZUK J,SAN-JUAN-VERGARA H,et al.Gut microbiota components are associated with fixed airway obstruction in asthmatic patients living in the tropics[J].Sci Rep,2018,8(1):9582.DOI:10.1038/s41598-018-27964-3. [48]BARCIK W,PUGIN B,BRESCó M S,et al.Bacterial secretion of histamine within the gut influences immune responses within the lung[J].Allergy,2019,74(5):899-909.DOI:10.1111/all.13709. [49]SKALSKI J H,LIMON J J,SHARMA P,et al.Expansion of commensal fungus Wallemia mellicola in the gastrointestinal mycobiota enhances the severity of allergic airway disease in mice[J].PLoS Pathog,2018,14(9):e1007260.DOI:10.1371/journal.ppat.1007260. [50]KIM Y G,UDAYANGA K G S,TOTSUKA N,et al.Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE2[J].Cell Host Microbe,2014,15(1):95-102.DOI:10.1016/j.chom.2013.12.010. [51]RAFTIS E J,DELDAY M I,COWIE P,et al.Bifidobacterium breve MRx0004 protects against airway inflammation in a severe asthma model by suppressing both neutrophil and eosinophil lung infiltration[J].Sci Rep,2018,8:12024.DOI:10.1038/s41598-018-30448-z. [52]ZHANG J,MA J Y,LI Q H,et al.Lactobacillus rhamnosus GG induced protective effect on allergic airway inflammation is associated with gut microbiota[J].Cell Immunol,2018,332:77-84.DOI:10.1016/j.cellimm.2018.08.002. [53]SPACOVA I,VAN BEECK W,SEYS S,et al.Lactobacillus rhamnosus probiotic prevents airway function deterioration and promotes gut microbiome resilience in a murine asthma model[J].Gut Microbes,2020,11(6):1729-1744.DOI:10.1080/19490976.2020.1766345. [54]ZHANG Z,SHI L,PANG W,et al.Dietary fiber intake regulates intestinal microflora and inhibits ovalbumin-induced allergic airway inflammation in a mouse model[J].PLoS One,2016,11(2):e0147778.DOI:10.1371/journal.pone.0147778. [55]OTTMAN N,RUOKOLAINEN L,SUOMALAINEN A,et al.Soil exposure modifies the gut microbiota and supports immune tolerance in a mouse model[J].J Allergy Clin Immunol,2019,143(3):1198-1206.e12.DOI:10.1016/j.jaci.2018.06.024. [56]ALLAIS L,KERCKHOF F M,VERSCHUERE S,et al.Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut[J].Environ Microbiol,2016,18(5):1352-1363.DOI:10.1111/1462-2920.12934. [57]FITCH M N,PHILLIPPI D,ZHANG Y,et al.Effects of inhaled air pollution on markers of integrity,inflammation,and microbiota profiles of the intestines in apolipoprotein E knockout mice[J].Environ Res,2020,181:108913.DOI:10.1016/j.envres.2019.108913. [58]VIGNAL C,PICHAVANT M,ALLEMAN L Y,et al.Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon[J].Part Fibre Toxicol,2017,14(1):46.DOI:10.1186/s12989-017-0227-z. [59]BIEDERMANN L,ZEITZ J,MWINYI J,et al.Smoking cessation induces profound changes in the composition of the intestinal microbiota in humans[J].PLoS One,2013,8(3):e59260.DOI:10.1371/journal.pone.0059260. [60]REALE M,BOSCOLO P,BELLANTE V,et al.Daily intake of Lactobacillus casei Shirota increases natural killer cell activity in smokers[J].Br J Nutr,2012,108(2):308-314.DOI:10.1017/s0007114511005630. [61]OJHA U C,SINGH D P,CHOUDHARI O K,et al.Correlation of severity of functional gastrointestinal disease symptoms with that of asthma and chronic obstructive pulmonary disease:a multicenter study[J].Int J Appl Basic Med Res,2018,8(2):83-88.DOI:10.4103/ijabmr.ijabmr_258_17. [62]吴永红,陈军,罗洲.慢性阻塞性肺疾病肠道微生态与炎症因子及临床指标的相关性[J].实用医学杂志,2020,36(5):634-638,644.DOI:10.3969/j.issn.1006-5725.2020.05.018. [63]邓素敏,朱涛峰,陈如华,等.慢性阻塞性肺疾病稳定期患者肠道菌群状态与炎性指标及肺功能的相关性分析[J].中国全科医学,2020,23(17):2137-2141.DOI:10.12114/j.issn.1007-9572.2019.00.644. [64]ANTOSCA K,CHERNIKOVA D A,RUOFF K L,et al.Altered stool microbiota of infants with cystic fibrosis shows a reduction in genera associated with immune programming[J].J Bacteriol,2019,201(16):e00274-19.DOI:10.1128/JB.00274-19. [65]HOEN A G,LI J,MOULTON L A,et al.Associations between gut microbial colonization in early life and respiratory outcomes in cystic fibrosis[J].J Pediatr,2015,167(1):138-147,e3.DOI:10.1016/j.jpeds.2015.02.049. [66]ENAUD R,HOOKS K B,BARRE A,et al.Intestinal inflammation in children with cystic fibrosis is associated with Crohn's -like microbiota disturbances[J].J Clin Med,2019,8(5):645.DOI:10.3390/jcm8050645. [67]KANHERE M,HE J,CHASSAING B,et al.Bolus weekly vitamin D3 supplementation impacts gut and airway microbiota in adults with cystic fibrosis:a double-blind,randomized,placebo-controlled clinical trial[J].J Clin Endocrinol Metab,2018,103(2):564-574.DOI:10.1210/jc.2017-01983. [68]SCHNAPP Z,HARTMAN C,LIVNAT G,et al.Decreased fecal calprotectin levels in cystic fibrosis patients after antibiotic treatment for respiratory exacerbation[J].J Pediatr Gastroenterol Nutr,2019,68(2):282-284.DOI:10.1097/mpg.0000000000002197. [69]LI W,ZHU Y,LIAO Q,et al.Characterization of gut microbiota in children with pulmonary tuberculosis[J].BMC Pediatr,2019,19(1):445.DOI:10.1186/s12887-019-1782-2. [70]NEGI S,PAHARI S,BASHIR H,et al.Gut microbiota regulates mincle mediated activation of lung dendritic cells to protect against Mycobacterium tuberculosis[J].Front Immunol,2019,10:1142.DOI:10.3389/fimmu.2019.01142. [71]HU Y F,FENG Y Q,WU J N,et al.The gut microbiome signatures discriminate healthy from pulmonary tuberculosis patients[J].Front Cell Infect Microbiol,2019,9:90.DOI:10.3389/fcimb.2019.00090. [72]MAJLESSI L,SAYES F,BUREAU J F,et al.Colonization with helicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of mycobacterium tuberculosis[J].Mucosal Immunol,2017,10(5):1178-1189.DOI:10.1038/mi.2016.140. [73]ARNOLD I C,HUTCHINGS C,KONDOVA I,et al.Helicobacter hepaticus infection in BALB/c mice abolishes subunit-vaccine-induced protection against M.tuberculosis[J].Vaccine,2015,33(15):1808-1814.DOI:10.1016/j.vaccine.2015.02.041. [74]VORKAS C,WIPPERMAN M,LI K,et al.Mucosal-associated invariant and γδ T cell subsets respond to initial mycobacterium tuberculosis infection[J].JCI Insight,2018,3(19):e121899.DOI:10.1172/jci.insight.121899. [75]CHEN W Q,ZHENG R S,BAADE P D,et al.Cancer statistics in China,2015[J].CA:A Cancer J Clin,2016,66(2):115-132.DOI:10.3322/caac.21338. [76]ZHUANG H,CHENG L WANG Y,et al.Dysbiosis of the gut microbiome in lung cancer[J].Frontiers Media SA,2019,9:112.DOI:10.3389/fcimb.2019.00112. [77]GUI Q,LI H,WANG A,et al.The association between gut butyrate-producing bacteria and non-small-cell lung cancer[J].J Clin Lab Anal,2020,34(6):e23318.DOI:10.1002/jcla.23318. [78]LIU F,LI J J,GUAN Y B,et al.Dysbiosis of the gut microbiome is associated with tumor biomarkers in lung cancer[J].Int J Biol Sci,2019,15(11):2381-2392.DOI:10.7150/ijbs.35980. [79]YU G,GAIL M H,CONSONNI D,et al.Characterizing human lung tissue microbiota and its relationship to epidemiological and clinical features[J].Genome Biol,2016,17(1):163.DOI:10.1186/s13059-016-1021-1. [80]YAN X,YANG M,LIU J,et al.Discovery and validation of potential bacterial biomarkers for lung cancer[J].Am J Cancer Res,2015,5(10):3111-3122. [81]KIM K,KWON O,RYU T Y,et al.Propionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer[J].Mol Med Rep,2019,20(2):1569-1574.DOI:10.3892/mmr.2019.10431. [82]XU J,LIAN F M,ZHAO L H,et al.Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula[J].ISME J,2015,9(3):552-562.DOI:10.1038/ismej.2014.177. [83]ZHI H,JIN X,ZHU H,et al.Exploring the effective materials of flavonoids-enriched extract from Scutellaria baicalensis roots based on the metabolic activation in influenza A virus induced acute lung injury[J].J Pharm Biomed Anal,2020,177:112876.DOI:10.1016/j.jpba.2019.112876. [84]CHEN M Y,LI H,LU X X,et al.Houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice[J].Chin J Nat Med,2019,17(3):187-197.DOI:10.1016/s1875-5364(19)30021-4. [85]ZHU H,LU X,LING L,et al.Houttuynia cordata polysaccharides ameliorate pneumonia severity and intestinal injury in mice with influenza virus infection[J].J Ethnopharmacol,2018,218:90-99.DOI:10.1016/j.jep.2018.02.016. [86]SHI C C,ZHU H Y,LI H,et al.Regulating the balance of Th17/Treg cells in gut-lung axis contributed to the therapeutic effect of houttuynia cordata polysaccharides on H1N1-induced acute lung injury[J].Int J Biol Macromol,2020,158:52-66.DOI:10.1016/j.ijbiomac.2020.04.211. [87]DING Z H,ZHONG R X,YANG Y N,et al.Systems pharmacology reveals the mechanism of activity of Ge-Gen-Qin-Lian decoction against LPS-induced acute lung injury:a novel strategy for exploring active components and effective mechanism of TCM formulae[J].Pharmacol Res,2020,156:104759.DOI:10.1016/j.phrs.2020.104759. [88]付雯,刘兴隆,张珑琼,等.3种方法治疗肠道菌群失调合并过敏性哮喘大鼠对肠道菌群的影响[J].重庆医学,2017,46(25):3477-3479,3483.DOI:10.3969/j.issn.1671-8348.2017.25.007. |
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