关键词: SAPHO综合征, 获得性骨肥大综合征, 痤疮, 中草药, 病例报告

Abstract: SAPHO syndrome is a rare heterogeneous disease mainly characterized by inflammatory lesions of the skin and/or bone and joint.Its typical skin manifestations include aseptic pustulosis and severe acne.In addition，it also involves suppurative hyperhidrosis，psoriasis vulgaris and so on，while the skin disorder may also be absent.The subtypes of SAPHO syndrome have not been recognized，and there is no consensus on whether the various subtypes should be treated differently.So far，few cases of SAPHO syndrome treated by TCM have been reported，especially those with severe acne.A case of SAPHO syndrome with severe acne is reported in this paper，who was admitted to Rheumatology Department，Xiyuan Hospital，China Academy of Chinese Medical Sciences on April 27，2017 with a chief complaint of a three-year history of facial inflammatory papules，nodules，and cysts，and a two-week history of pain in the right gluteal region and right hip.He was diagnosed with SAPHO syndrome with severe acne and his conditions were improved significantly by TCM treatment，revealing that the subtype is mainly developed due to the stasis of dampness，heat and toxin in essence with tendon clonus as external manifestation，so the priority of treatment should be given to the use of heat-clearing and detoxifying drugs，antispasmodic and analgesic drugs，heart-entering meridian drugs and rattan drugs，while discussing the necessity and feasibility of SAPHO syndrome subtype classification based on a literature review.

Key words: SAPHO syndrome；Acquired hyperostosis syndrome；Acne；Drugs, Chinese herbal；Case reports