关键词: 肺疾病, 慢性阻塞性, 严重程度, 合并症, 肌营养不良, 肌, 骨骼, 肺功能

Abstract: Background　Chronic obstructive pulmonary disease（COPD） is one of the world's leading lethal chronic diseases，which continues to the increase of global economic burden.Skeletal muscle malnutrition，as one of the common complications of COPD，seriously affects patient's quality of life and prognosis，but the research on its mechanism，prevention and treatment is currently incomplete.Objective　To explore the correlation between the severity of COPD and skeletal muscle malnutrition.Methods　From September in 2017 to June in 2019，205 COPD patients who treated in the First Affiliated Hospital of Jinzhou Medical University were selected as the case group，and 125 healthy people who underwent physical examination at the same period were selected as the control group（gender and age matched to case group）.Various body composition indexes and pulmonary function after diastole were measured in two groups.Univariate analysis was used to compare the body composition indexes of two groups.Pearson correlation analysis and Spearman's rank correlation were used to explore the correlation between percentage of forced expiratory volume in 1 second（FEV1%） predicted，inspiratory capacity and total lung capacity ratio（IC/TLC），and various body composition indexes.Results　The BMI，fat-free mass（FFM），total muscle mass，trunk muscle mass，double upper limb muscle mass，double lower limb muscle mass，limb muscle mass，grip strength，skeletal muscle index，and fat-free BMI of male patients with COPD were lower than those of male patients in control group（P<0.05）.Female patients with COPD had lower BMI，FFM，total muscle mass，trunk muscle mass，double upper limb muscle mass，double lower limb muscle mass，limb muscle mass，grip strength，skeletal muscle index，and fat-free BMI than females in the control group（P<0.05）.The correlation analysis showed that IC/TLC had positive correlation with FFM，total muscle mass，trunk muscle mass，double upper limb muscle mass，double lower limb muscle mass，limb muscle mass，grip strength，skeletal muscle index，and fat-free BMI in male COPD patients（P<0.05），and IC/TLC had positive correlation with BMI，FFM，total fat mass，total muscle mass，trunk muscle mass，double upper limb muscle mass，double lower limb muscle mass，limb muscle mass，grip strength，skeletal muscle index，fat-free BMI，and fat BMI in female COPD patients（P<0.05）.Except that FEV1% in male COPD patients had a linear positive correlation with grip strength（P<0.05），FEV1% had no correlation with other body composition indexes in male and female COPD patients（P>0.05）.Conclusion　BMI，FFM，muscle mass，and grip strength of COPD patients are lower than those of healthy people.Body composition indexes of COPD patients are not related to FEV1%，but have significant correlation with IC/TLC，another index that reflects the severity of the disease.

Key words: Pulmonary disease, chronic obstructive；Severity；Complication；Muscular dystrophies；Muscle, skeletal；Pulmonary function