Vascular endothelial growth factor signaling pathway (VSP) inhibitors have gradually increased and been widely used recently, with a high incidence of inducing hypertension adverse events. VSP inhibitor induced hypertension is difficult to diagnose in a timely and the management of uncontrolled blood pressure is neglected, active blood pressure management strategies are essential. This paper summarized the status of VSP inhibitors treatment and its related hypertension, as well as the blood pressure management strategies for VSP inhibitor-related hypertension. The aim was to increase the awareness of VSP inhibitor-related hypertension among healthcare professionals and provide blood pressure management strategies for patients using VSP inhibitors to improve blood pressure control and cardiovascular health.
Annexin A1 (ANXA1) is a potent anti-inflammatory protein, and research progress regarding its role in respiratory diseases has increasingly attracted attention. Research indicates that ANXA1 may participate in the pathophysiological process of respiratory diseases by regulating inflammatory response, clearing oxidative stress substances, and influencing cell apoptosis. However, there is currently a lack of effective integration in the research on ANXA1's involvement in the aforementioned disease processes. This article systematically and comprehensively summarizes the effects of ANXA1 on chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis, lung ischemia-reperfusion injury and lung cancer by reviewing relevant literature from recent years. It explores the mechanisms by which ANXA1 is involved in the occurrence and progression of these diseases. Research shows that ANXA1 exerts anti-inflammatory effects by regulating various inflammatory signaling pathways, participating in the inhibition of leukocyte migration, adhesion, and neutrophil apoptosis, suppressing airway hyperreactivity in asthma, alleviating pulmonary inflammation in COPD, and improving pulmonary fibrosis. In addition, ANXA1 also affects the proliferation, metastasis, and invasion of tumor cells. This article can provide a reference for the treatment of ANXA1 in respiratory diseases and serve as a guide for further in-depth research.
Type 1 diabetes mellitus (T1DM) is currently considered to be a chronic autoimmune disease caused by destruction of pancreatic β-cells. It is mainly caused by a combination of genetic and environmental factors that lead to destruction of pancreatic β-cells, which results in an absolute lack of insulin secretion in the body and a lifelong dependence on extracorporeal insulin therapy. As the incidence of T1DM continues to increase globally, more attention has been paid to the prevention and treatment of T1DM. Numerous studies have demonstrated that vitamin D, in addition to its value in bone metabolism and calcium-phosphorus homeostasis, also plays an important role in the development and progression of chronic inflammatory and immune-related diseases. Therefore, on the basis of introducing the epidemiology of T1DM and the role of vitamin D, this article further elaborates the correlation between vitamin D and T1DM and its complications, with a view to providing a theoretical basis for clinicians to comprehensively diagnose and treat T1DM.
The prevalence rate of type 2 diabetes is increasing year by year. It is known that oxidative stress and inflammation can participate in the occurrence and development of diabetes. Dipeptidyl peptidase-4 (DPP-4) inhibitors can enhance the incretin effect by inhibiting DPP-4, thus playing a hypoglycemic role, and have been widely used in the treatment of diabetes patients. Currently, studies have shown that DPP-4 expression is up-regulated in a variety of inflammatory diseases, suggesting that it may be involved in the occurrence of inflammation. However, there are few relevant reports on the mechanism of action of DPP-4 inhibitor in inflammation and oxidative stress. Therefore, this paper reviews the anti-inflammatory and antioxidant stress mechanism of sitagliptin, a DPP-4 inhibitor, and proposes that sitagliptin has certain application prospects in the treatment of other diseases, providing references for subsequent relevant studies.
Subjective cognitive decline (SCD) usually predicts the risk of future cognitive decline, and sleep disturbances are very common in patients with SCD and often precede detectable cognitive changes. Although there is a lack of clarity regarding the relationship between sleep and SCD and the underlying mechanisms of sleep-related cognitive deterioration, studies in recent years have shown a strong link between sleep and cognitive decline. Cognitive decline may be triggered by either sleep deprivation or decreased sleep quality. Therefore, the aim of this review is to provide a comprehensive overview of the research progress on sleep and subjective cognitive decline, and to explore in depth the mechanism of their interaction, with a view to providing new ideas and methods for preventing and delaying cognitive decline, and providing useful references for research and practice in related fields.
The gastric precancerous conditions includes gastric mucosal atrophy and intestinal metaplasia, which is key link in the occurrence and development of gastric cancer, and its prevalence is on the rise in China. This paper details the conceptual difference between gastric precancerous conditions and precancerous lesions, identifies the evaluation methods of patients with high risk of carcinogenesis in gastric precancerous conditions from the aspects of endoscopy, pathological histology, and biomarkers, and summarizes the pathogenesis of gastric precancerous conditions. This paper shows that the cancer risk of gastric precancerous conditions is related to various factors such as the degree, range and subtype of lesions. In the microenvironment of gastric mucosa, imbalance and disorder of oxidation and antioxidant effect, energy metabolism, immune homeostasis, cell proliferation and death are the pathogenesis of gastric precancerous conditions. A comprehensive and prudent assessment of the cancer risk of gastric precancerous conditions is needed in clinical practice, thus providing patients with appropriate surveillance and follow-up programs to improve the detection rate of early gastric cancer. This paper can provide powerful evidence-based medical evidence for high-risk screening and prevention measures of gastric precancerous conditions in China, provide a reference for the in-depth development of mechanism research and new drug development.
As a non-invasive and non-radiative non-contact clinical detection technology, infrared thermography can identify various diseases early by detecting the body surface temperature and reconstructing the temperature distribution image, and achieve early diagnosis and intervention. This article focuses on reviewing the application and related research progress of infrared thermography in the fields of acute respiratory infectious diseases, sleep apnea syndrome, traditional Chinese medicine lung disease research, neonatal intensive care, and early screening of pulmonary embolism, which has important clinical guidance significance. As a Functional imaging technology, the core advantage of infrared imaging is "Early". Unlike structural changes in the course of a disease, the early stages of a disease are often Hemodynamics, the functional changes of local abnormal temperature distribution caused by local inflammation and so on can be early diagnosed, early intervention and dynamic monitoring by means of infrared thermography technology based on thermal sensitivity.
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. It is characterized by high morbidity and mortality. Therefore, early detection, early diagnosis and early treatment are very important. Sensitive and convenient serological biomarkers play a key role in the diagnosis and treatment of HCC. However, traditional biomarkers such as alpha-fetoprotein fall far short of the clinical needs. Liver is an important organ of metabolism in the body. The occurrence and development of HCC are closely related to metabolism. Metabolomics is a newly developed subject. It has certain advantages in the screening diagnosis, mechanism exploration, precise treatment, prognosis judgment and efficacy evaluation of HCC. As an important part of systems biology, metabolomics technology can screen differentially expressed metabolites in the tissues, blood and urine of HCC patients. On the one hand, these metabolites can be used as biomarkers for early diagnosis and prognosis evaluation of HCC. On the other hand, these metabolites can also clarify the metabolic mechanism in the development and progression of HCC, which can be used to develop new drugs and new targets for the treatment of HCC. This article reviews the research progress of metabolomics in the diagnosis and treatment of HCC, in order to provide a theoretical basis for the screening of HCC biological diagnostic markers and potential therapeutic targets.
Cognitive impairment is also known as cognitive disorders. With the rapid aging of the population, the number of people affected by cognitive disorders and the Alzheimer's disease is on the rise. The stigma associated with cognitive disorder is widely recognized in the international community, but related research in this field remains limited. This paper found that definition and measurement of stigma of cognitive disorders need to be standardized, there is a lack of research on economically underdeveloped areas and evidence to establish causal inference; and there is ample room for improvement in both the quantity and quality of intervention studies. The research on stigma of cognitive disorders provides an unique opportunity to break the binary subject perspective in the traditional field of stigma research. At the same time, the discussion on the mechanism of cognitive disorder stigma formation can also deepen the academic discussion on labeling theory and attribution theory.
Alzheimer's disease (AD) is a common neurodegenerative disease in the elderly population. It's typical clinical manifestation is progressive memory impairment. Ferroptosis, rising as a new research direction on AD biological mechanism in recent years, mainly studies on iron-dependent programmed cell death. A large amount of evidence has shown that AD is closely related to ferroptosis in the brain. However, the exact mechanism of the role ferroptosis has played in AD is still unclear. One of the most popular research results indicates that AD might be induced by iron metabolism disorders, lipid peroxidation, and amino acid metabolism, thereby affecting the deposition of iron ions in the brain. So far, some effective chemical components of traditional Chinese herbs as cures of AD have been studied in depth, such as rhodiola rosea, polygala root, ginkgo biloba, poria cocos, etc. These traditional Chinese herbs have shown remarkable effects in the treatment of AD by means of targeting ferroptosis. In this context, this review systematically elaborates on the metabolism of iron in the brain, the characteristics of ferroptosis, and focuses on the metabolic regulation mechanism of ferroptosis. Meanwhile, this review also discusses the connection between ferroptosis and AD. Furthermore, it lists the effective compositions in traditional Chinese herbs that can improve AD by inhibiting ferroptosis, so as to provide reference information for the development and research of ferroptosis inhibitors in the future.
Obstructive sleep apnea (OSA) is one of the most common sleep disorders, which is closely related to a variety of cardiovascular diseases, and has become one of the key directions for the control and prevention of cardiovascular disease risk factors. In recent years, many clinical studies have confirmed that OSA is closely related to the initiation and evolution of acute coronary syndrome (ACS). Therefore, this article summarized the status quo of clinical studies on OSA and ACS, the shortcomings of current studies, and prospects for future research directions.
Prediabetes is a condition characterized by impaired fasting glucose, impaired glucose tolerance, or a combination of both, which is classified under the category of "Pi Dan" in Traditional Chinese Medicine (TCM). With the changes in modern lifestyles, the prevalence of prediabetes is continuously rising, carrying a risk comparable to diabetes prognosis. Therefore, timely diagnosis and early intervention are crucial. This article reviewed the origins and definitions of prediabetes from both TCM and modern medical perspectives, revealing that TCM had already recognized "Pi Dan" as early as the composition of the "SuWen". With the development of evidence-based medicine and the implementation of standardized clinical research, China has gradually established the standardized clinical practice guidelines for prediabetes with TCM characteristics. Regarding diagnosis, diagnostic indicators and thresholds for monitoring blood glucose levels, various non-invasive integrated TCM and modern medical diagnostic methods, including TCM syndrome diagnosis, integrated TCM and Western medicine diagnostic models, disease risk scoring models, biomarkers, and wearable devices, have been continuously improved. However, its primary focus lies in diabetes prevention rather than the early detection and screening of prediabetes. Besides, 1-hour plasma glucose may be a new outcome for prediabetes diagnosis or identifying high-risk diabetes populations in the future. However, further research is required to validate its broader application. Addressing the challenges of dynamic diagnostic standards, complex screening processes, atypical clinical symptoms, and low disease awareness during early prediabetes diagnosis, it is imperative to continuously update and refine diagnostic standards. The integration of digital health management and wearable devices should be promoted to fully capitalize on TCM strengths in constructingt disease diagnostic models that combine TCM macro manifestations and omics microdata for prediabetes. Simplified and expedited integrated TCM and modern medical screening methods can facilitate early screening, early diagnosis, early intervention, and early recovery for prediabetes.
In recent years, the Internet of Things technology (IoT) has been developed extremely rapidly, and has been widely applied in the medicine field. Chronic obstructive pulmonary disease (COPD) is one of the most common chronic respiratory diseases in China, and it is worth exploring how IoT can be used to improve the clinical practice of COPD management. We summarized the research progress of IoT technology in COPD management at home and abroad and found that the current research on the application of IoT in COPD management is still in the exploratory stage and lacks high-quality, large-sample studies by reviewing the literature. Real-world studies are needed to conduct systematic evaluation of designed mature models or products in the future, especially the impacts on long-term clinical outcomes of patients, quality of life and health economics evaluation. Products design should be tailored to the characteristics and target of COPD and the characteristics of users, and emphasis should also be placed on qualitative researches to understand the experiences, opinions or attitudes of users toward such products.
Heart failure patients are prone to depression, and interact with each other, leading to lower quality of life and poor prognosis of patients. As the largest microecosystem in the human body, changes in the composition, structure and function of the gut microbiota are closely related to the physiological and pathological states of the host. Currently, the "gut-heart/brain axis" has been used to explain the link between gut microbiota, cardiovascular diseases, and mood states, which is an important comorbid basis for heart failure and depression. In this paper, we reviewed the mechanisms of gut microbiota, metabolites, and vagus nerve in the development of heart failure and depression, and propose that mediterranean diet, probiotics, and microbiota transplantation have the potential to improve the "microbiota-gut-heart/brain axis", providing a new perspective for the treatment of heart failure patients comorbid with depression.
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a clinically common functional gastrointestinal disease, in which immune imbalance plays an important role. Related immune cells include innate immune cells and adaptive immune cells, and immune cytokines include immunoglobulin, interferon, interleukin, tumor necrosis factor, etc. Traditional Chinese medicine monomers/compounds or compound formulas can regulate immunotherapy for IBS-D through multi-pathway, multi-target. This article systematically reviews and sorts out relevant literature on targeted immunotherapy of IBS-D using traditional Chinese medicine monomers/compounds and compound therapies from the perspectives of immune imbalance and intestinal infection, dysbiosis of flora, brain-gut axis disorder, and endocrine disorders. At the same time, it confirms the similarities between the "spleen as the guard" and immunity, to provide ideas for traditional Chinese medicine to treat IBS-D and related diseases through immune-mediated pathways.
Pathologic pain is a serious chronic disease, including inflammatory pain, neuropathic pain and cancer pain. Previous studies have proved a close correlation of estrogen and its receptors with pathologic pain, which plays an important role in its occurrence and development, therefore, it has attracted the attention of many researchers at home and abroad. Combining the relevant literature at home and abroad in recent years, this paper reviews the relevant research progress of the mechanism of estrogen and its receptors in pathologic pain, in order to provide a theoretical basis for the prevention and treatment of pathologic pain, as well as the guidance for future research.
Diabetic hyperglycemia in males is a significant contributing factor to the development of spermatogenesis disorder. The hypothalamic-pituitary-gonadal (HPG) axis serves as a crucial center for autonomic sexual function and the neuroendocrine network within the human body. It dominates physiological prominence in human reproduction, growth, and development, while also being susceptible to hyperglycemia, which is one of the key mechanisms in the development of spermatogenic disorder in type 2 diabetes mellitus (T2DM). This mechanism involves kidney deficiency, which is a common etiology and pathogenesis of both spermatogenesis disorder and T2DM. The kidney storing essence, which encompasses the functions of "dominating reproduction, manufacturing marrow to fill up the brain" bears similarities to the HPG axis. Kidney tonifying therapy can regulate and improve the function of HPG axis, thereby establishing a theoretical basis for the use of kidney tonification therapy in the treatment of spermatogenesis disorder in T2DM. The traditional formula of tonifying the kidney can serve as a complementary treatment for both DM and spermatogenesis disorder. This approach offers a conceptual framework and methodology for the prevention and treatment of T2DM-induced infertility through kidney tonification.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a major public health emergency in the world, which poses a major threat to the global health system. After rehabilitation from SARS-CoV-2 infection, some patients may experience multiple respiratory symptoms for a long time, which is called the acute sequelae of SARS-CoV-2 infection. Post-COVID-19 pulmonary fibrosis (PCPF) as one of them, can affect the respiratory function and quality of life of patients to varying degrees. Regarding the treatment of PCPF is a hot topic in current research, and this article provides a review of treatment methods for PCPF, aiming to improve the prognosis of PCPF patients.
The diagnosis and treatment of disorder of consciousness (DOC) is still challenging. One of the neural mechanisms of DOC is the destruction of synchronization and connectivity of neural oscillation. This article will review the progress of neural oscillation in the diagnosis and treatment of DOC from three aspects: theoretical basis, application progress, and existing deficiencies of neural oscillations applied to DOC. Neural oscillation is the periodic and synchronous activity of neurons under certain conditions. There are obvious differences in the spectrum characteristics, phase synchronization, and response to neural regulation of neural oscillations among different severities of DOC. The analysis of neural oscillation based on electroencephalography (EEG) reveals the information transmission and processing ability at different levels of consciousness, which is helpful to distinguish different degrees of DOC more accurately and achieve the purpose of DOC wakening treatment by regulating neuro oscillation. Despite there being some problems like insufficient mechanism studies and slow application transformation, neural oscillation has shown great application potential in the diagnosis and treatment of DOC.
Non-alcoholic fatty liver disease (NAFLD) is a progressive disease. NAFLD, viral hepatitis B, viral hepatitis C, and alcoholic liver disease are the major cause of chronic liver disease in the world. Without effective intervention measures, NAFLD can gradually deteriorate to non-alcoholic steatohepatitis, fatty liver fibrosis, liver cirrhosis and even hepatocellular carcinoma, and may become the main cause of end-stage liver disease in the future. The prevalence and incidence of NAFLD are increasing in the world, and the problem is becoming more and more serious. On the basis of relevant data collection and literature research, this article analyzes the epidemiological characteristics in gender and region of NAFLD, and discusses the possible effects of hormones and environment, and other risk factors on NAFLD, so as to provide new ideas for the prevention and control of NAFLD.
Atrial fibrillation (AF) is among the most prevalent types of arrhythmia, leading to severe complications such as heart failure and stroke, thus increasing rates of mortality and disability. Silent AF, which lacks clinical symptoms and has irregular onset, tends to have a low diagnosis rate and often experiences delays in receiving standardized treatments, resulting in negative clinical outcomes. Recent clinical studies highlight the significant benefits of wearable devices in the screening and management of silent AF. In this article, we review the clinical outcomes, cost-effectiveness, challenges and future application prospects of wearable devices in the detection and management of silent AF based on relevant domestic and international literature of recent years to provide more evidence-based support for its further applications.
Preserved ratio impaired spirometry (PRISm) is a common pulmonary functional impairment, considered a pre-chronic obstructive pulmonary disease stage and has received increased attention from the academic community in recent years. Despite a comprehensive review of the etiology, epidemiology, and risk factors of the PRISm population, there is a lack of systematic review for chest CT imaging. To gain a more comprehensive understanding of this population, this article summarizes the chest CT imaging features of the PRISm population using both visual and quantitative assessment methods, including the characteristic changes of airways, lung parenchyma, and vessels. The article indicates that the reference value of visual assessment of chest CT results for the PRISm population is limited, while quantitative assessment of chest CT, combined with pulmonary function testing, is advantageous in gaining a deeper understanding of the lung structural features of the PRISm population. Future studies are expected to employ a more systematic approach through prospective, large-sample, multi-center cohort studies to elucidate the characteristics of the PRISm population in chest imaging.
Senescence-associated secretory phenotype (SASP) is an important feature of cellular senescence and plays an important role in regulating the disease microenvironment. At present, the role of SASP in intervening bone metabolism and inducing bone loss is very limited. Therefore, this paper discusses the regulatory mechanism of SASP in osteoporosis models and summarizes its regulatory characteristics: SASP is fully expressed in senescent bone cells and transmits aging effects to mesenchymal stem cells in an autocrine/paracrine manner, thereby interfering with osteogenic differentiation. SASP activates immune cells and promotes their aging, thus inducing the formation of inflammatory tissue microenvironment and aggravating bone loss. Mitochondrial homeostasis, pathologic hyperglycemia, and obesity-induced fat accumulation all promote SASP expression, thus disrupting microenvironmental homeostasis and transmitting aging effects to bone tissue. To sum up, understanding the role of SASP in osteoporosis lays a solid foundation for us to develop anti-SASP therapy for osteoporosis in the future.
Henoch-Schonlein purpura is a vascular inflammatory illness that develops in childhood and in some children involves the kidneys, clinically known as Henoch-Schonlein purpura nephritis. Different studies have suggested different interventions, and there is a wide variation in the outcome indicators used for the intervention approaches.
To investigate and analyze the current status of clinical research outcome indicators for Henoch-Schonlein purpura nephritis in China, so as to provide a reference basis for the establishment of a core set of outcome indicators in this field.
CNKI, CBM, VIP, Wanfang Data, PubMed, Cochrane Library, Embase and Web of Science were systematically searched to collect publicly available Henoch-Schonlein purpura nephritis studies from January 2010 to June 2021. The Chinese databases were searched using the search strategy of title or keywords combined with subject terms, and the English databases were searched using subject terms combined with free words. Two investigators independently screened the literature and extracted information according to the inclusion and exclusion criteria, processed and analyzed the data on outcome indicators.
A total of 148 randomized controlled trials of Henoch-Schonlein purpura nephritis were included, and the outcome indicators of Henoch-Schonlein purpura nephritis studies were mainly physical and chemical indicators, with fewer symptomatic indicators. The highest frequency of outcome indicators were clinical efficacy (121 times, 81.76%), adverse reactions (74 times, 50.00%), 24-hour urine protein (68 times, 45.95%), urinary red blood cells (43 times, 29.05%), and recurrence rate (20 times, 13.51%). The division between primary and secondary outcome indicators was clearly distinguished in only two articles.
There are several indicators for the research outcomes of Henoch-Schonlein purpura nephritis in China, primarily physical and chemical variables, with significant variation. The research focuses on efficacy measures but ignores adverse reactions. As a result, it is necessary to establish a set of outcome indicators for clinical intervention studies on Henoch-Schonlein purpura nephritis in order to provide a reference basis for selecting outcome indicators and guiding clinical decision-making in future similar studies.
The low-pressure and low-oxygen environment at high altitude causes a series of changes in the metabolic level in the human body. The high altitude environment increases the level of oxidative stress and homocysteine in the body, which damages vascular endothelial cells. Hyperhomocysteinemia exacerbates oxidative stress, further aggravates the damage to the vascular endothelium, and accelerates the occurrence and development of hypertension. The combination of antioxidant drugs on the basis of traditional antihypertensive drug treatment provides a new direction for the treatment of H-type hypertension in high-altitude areas. This article reviews the relationship between vascular endothelial function and oxidative stress in patients with H-type hypertension in high-altitude areas, and explores its pathogenesis and possible treatments.
Cardiovascular disease (CVD) is a major cause of human mortality worldwide, characterized by its insidious onset, intricate and variable course, and poor prognosis. Early identification and active intervention of potentially critically ill patients is essential to improve their prognosis.
To conduct a scoping review of the research on early warning assessment tools for cardiovascular disease risk at home and abroad, summarize and analyze their assessment content and application, ultimately providing reference for the selection of appropriate early warning tools for cardiovascular disease patients in China.
CNKI, Wanfang Data, VIP, CBM, PubMed, Web of Science, Cochrane Library, Embase, CINAHL, and Scopus were systematically searched from inception to May 2023. Two investigators independently screened literature and extracted data, analyzed in terms of assessment content, study subjects, validation method, reliability and validity, and predictive efficacy.
A total of 16 papers were included, comprising 7 papers on the development and validation of assessment tools and 9 papers on the localized application of these tools, involving 20 early warning assessment tools for cardiovascular disease risk. The results of the analysis showed that each assessment tool contained 3 to 17 assessment items, with the most frequently mentioned items of age, systolic blood pressure, respiratory rate, oxygen saturation, heart rate, comorbidities, level of consciousness, and gender. The results of the reliability and validity tests for 2 papers indicated robust reliability and validity, while all other studies lacked reliability and validity evaluations. Ten papers reported the area under the curve (AUC), with values ranging from 0.550 to 0.926 9.
Diverse early warning assessment tools for cardiovascular disease risk are available, however, their overall quality remains to be improved and there is a lack of specific assessment tools. In the future, it is imperative to conduct further validations of the reliability and validity of the existing tools, and develop localized early warning assessment tools specialized for cardiovascular diseases considering the unique characteristics of the disease, which exhibit robust reliability and validity.
With the aging and life expectancy increasing in China, sleep disorders in the elderly (≥80 years old) have received widespread attention. As one of the common problems, sleep disorders seriously affect the quality of life and physical and mental health among the elderly, and can also aggravate or induce multiple diseases.
To conduct a scoping review of studies on sleep disorders in community dwelling older adults over 80 years and provide guidance for the early diagnosis and treatment of sleep disorders in community dwelling older adults in China.
PubMed, Embase, CINAHL, Web of Science, Cochrane Library, OpenGrey, SinoMed, CNKI, Wanfang Data, and VIP databases were searched for literature on sleep disorders in community dwelling older adults from inception to March 15, 2023. Literature was independently screened by 2 investigators and basic characteristics of the literature were extracted (authors, time of publication, country, type of study, sample size, assessment tool or modality, prevalence, findings) .
A total of 10 486 papers were searched, and 21 papers were finally included, of which 14 were in English and 7 were in Chinese, 16 were cross-sectional studies, 2 were quasi-experiment studies and 3 were longitudinal studies. The results of the analysis indicated that sleep disorders were more prevalent with serious adverse effects in the community dwelling older adults aged over 80 years (the prevalence rate ranged from 10.0% to 60.3%), which were assessed by nine tools or modalities, including three structured scales with the more commonly used scale being Pittsburgh Sleep Quality Index (PSQI). The influencing factors of sleep disorders were divided into three categories of social demographic factors, physical health and disease-related factors, psychological and behavioral characteristic factors. Interventions such as music therapy, therapy combined with interaction mode groups were found to be effective in improving sleep disorders. However, few prevention and intervention studies were conducted.
The high prevalence of sleep disorders among older people in the community is high with serious effects, there is insufficient knowledge about sleep disorders among community dwelling older adults and fewer types of assessment tools lacking specificity in China. The influencing factors of sleep disorders among older people are complex and diverse, with a lack of research on prevention and intervention.
The glial lymphatic system is a recently discovered anatomical structure in the field of neuroscience, with functions such as regulation of interstitial fluid movement, waste removal and potentially brain immunity, playing an important role in physiology and pathology of the central nervous system. With the development of imaging technology, more and more magnetic resonance imaging (MRI) techniques have been applied to the study of the glial lymphatic system of the human brain. Currently, the commonly used imaging techniques include dynamic contrast-enhanced MRI, diffusion tensor image analysis along the perivascular space, and novel multimodal ultra-fast magnetic resonance techniques, etc. This article summarizes and reviews the application of these techniques in the brain glymphatic system, in order to provide a reference for the imaging study of the glymphatic system.
Metabolic fatty liver disease (MAFLD) is one of the most common chronic liver diseases worldwide, with a prevalence of up to 30% in China, and still rising. The disease is associated with genetic factors, environmental factors and patients' lifestyle habits, and is easily combined with various metabolism-related diseases such as diabetes, cardiovascular and cerebral vascular diseases, as well as serious complications such as liver cirrhosis and liver cancer. An increasing number of basic experimental and clinical studies have demonstrated the relevance of oral and gut microbiota to MAFLD, and targeted treatment of oral and gut microbiota may play an important role in the prevention and treatment of MAFLD. In this paper, we summarize the oral and gut microbiota characteristics of MAFLD patients based on the theory of the oral-gut-liver axis and the mechanism of the role of oral and gut microbiota dysbiosis on the development of MAFLD, hoping to provide ideas for the diagnosis and treatment of MAFLD.
Using discrete choice experiment (DCE) to study the employment preference of health personnel to choose jobs can provide scientific and efficient basis for the formulation of policies related to the attraction and retention of health personnel in rural and remote areas.
To review, summarize and generalize the researches on the application of DCE to the field of human resources for health, so as to provide reference for future research.
Web of Science, PubMed, CNKI, Wanfang and VIP were systematically searched for literature related to DCE application to the field of health human resources from February to April in 2022. The data of included studies such as study objectives, data analysis models, the choice item settings and results were extracted.
A total of 44 papers published from 2000 to 2020 were finally included. The study objects were mainly health workers in service and students; six studies were labeled and others were unlabeled in the included papers; the number of working attributes ranged from 4 to 8; the number of levels of working attributes was predominantly 2 to 4 (88.6%, 39/44). The teamwork of general practitioners and workload were used as working attributes in the studies in high-income countries; the most frequently selected working attribute in studies from low-and middle-income countries was housing (21 times), followed by essential equipment such as facilities and medications (19 times), and learning/training opportunities (16 times). Income (salary) was incorporated into the working attributes across the literature. Furthermore, we formulated a framework of working attributes containing four aspects: social aspects, including the hospital volume, social support/respect, identification (establishment or becoming a permanent employee) ; working aspects, including working location, working conditions, workload, working (management) atmosphere, teamwork, mentoring by supervisors (for primary health workers) ; career development aspects, including years of promotion, training (continuing education) opportunities, academic and research opportunities; life aspects, including income, housing, traffic, and children's education. Mixed Logit Model was the frequently used analytical model (19 times), followed by Conditional Logit Model (9 times), Generalized Multinomial Logit Model (3 times) .
The heterogeneity of research findings in this field is large, making it difficult to draw uniform conclusions. Moreover, the application of DCE in the field of human resources for health still needs to be promoted globally. Relevant studies are very limited and the evidence obtained needs to be confirmed by further research.
Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) and asthma are two prevalent chronic respiratory diseases. Recent research has revealed that OSAHS not only shares several common risk factors with asthma but also exhibits a high comorbidity rate with it. This mutual interaction complicates the course of both diseases and increases complexity to clinical diagnosis and treatment. This review aims to provide a comprehensive summary and analysis, from an epidemiological and pathophysiological perspective, of the research progress and challenges concerning the OSAHS comorbided with asthma, particularly in severe asthma.
Short-chain fatty acids (SCFAs) play a major mediating role in gut microbiota regulation of host metabolism and are strongly associated with type 2 diabetes mellitus (T2DM), which improves glycemic, body weight, and lipid indices in T2DM patients. Although it has been suggested that SCFAs are expected to be novel therapeutic targets for T2DM, no review has been conducted. Therefore, this paper summarizes the biological properties of SCFAs, discusses the evidence that SCFAs regulate appetite, inflammation, pancreatic β-cells, lipid metabolism and hepatic glycogen metabolism, further clarifies the progress of research on regulating the role of SCFAs in T2DM and their mechanisms, and explores the potential of regulating SCFAs for the treatment of T2DM.
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune encephalitis that is a rare complication of ovarian teratoma. The primary treatment is surgical resection of the tumor combined with immunotherapy, however, the pathogenesis of ovarian teratoma associated anti-NMDAR encephalitis is still unclear. In addition, the patients present with various clinical manifestations, with neurological manifestations predominating, which is easy to be misdiagnosed and overlooked, requiring joint diagnosis and treatment by gynecologists and neurologists. This article briefly describes the structure and function of NMDAR, reviews the previous research results on ovarian teratoma associated anti-NMDAR encephalitis, and summarizes the research progress on its pathogenesis, early diagnosis, differential diagnosis, treatment, prognosis and recurrence, aiming to provide theoretical basis and ideas for better diagnosis and treatment of ovarian teratoma associated anti-NMDAR encephalitis.
As a crucial component of the cardiac autonomic nervous system, the cardiac vagus nerve plays a significant role in the management of chronic heart failure. In recent years, several studies have found that vagus nerve stimulation protects cardiac function and delays the progression of chronic heart failure by reducing the expression of inflammatory factors and related proteins, apoptosis-related proteins, and improving myocardial function and ventricular remodeling. However, there are limited reports related to the mechanism of inflammation and apoptosis of the vagus nerve in chronic heart failure. Hence, this article reviews the anatomy of the cardiac vagus nerve, potential treatment mechanisms, practical parameters of vagus nerve stimulation, and the recent applications and clinical progress of vagus nerve stimulation in inflammation and apoptosis mechanisms in chronic heart failure, in order to provide a reference for the future related research.
Cancer is a significant global public health issue. With the continuous increase in cancer incidence rates and the prolonged survival time of cancer patients, the number of cancer survivors is also steadily rising. Cancer survivors face complex challenges in terms of physical, psychological, and social care, and their care services require effective coordination and integration across disciplines, sectors, and domains. Establishing integrated care model for cancer survivors has become an important strategy for addressing the challenges of survivorship care globally. However, the development of cancer survivorship care in China has been relatively lagging. This article synthesizes and summarizes the conceptual frameworks, characteristics and practical application of several representative integrated care models for survivorships. Based on China's healthcare service system, recommendations for designing and implementing integrated care strategies for cancer survivorships in China are proposed from five aspects: establishing consensus, pilot testing and exploration, workforce development, strengthening primary care, and policy support.
Cancer is a major traumatic event that causes serious interference in the pursuit of individual's life goals and leads to a variety of emotional disorders. Rational adjustment of life goals is beneficial to rebuild life direction, improve physical and mental health of patients. This paper reviews the current research of domestic and international studies on cancer affecting patients' pursuit of life goals, and summarizes the advances in the existing literature on the goal-adjustment behaviors of cancer patients and the effects on their physical and mental health by literature review. Literature review shows that the impact of cancer diagnosis on patients' pursuit of life goals is mainly manifested in the impact on self-efficacy, goal pursuit ability and goal prioritization. Reasonable goal-adjustment behaviors can help improve patients' physical and mental health, which includes promoting positive emotions, alleviating negative emotions, reducing physical discomfort, and improving quality of life. Therefore, future psychosocial intervention design for the emotional health of cancer patients can be based on guiding patients to replan and regulate their goals, so as to improve patients' emotional health and disease prognosis.
Sepsis is characterized by a dysregulation of immune response to infection, leading to life-threatening organ dysfunction. Sepsis-associated liver injury (SALI) is considered an independent risk factor for predicting death in the intensive care unit (ICU). With the increasing number of studies on the gut-liver axis in recent years, the close linkage of gut microbiota and liver diseases has been gradually revealed. Dysbiosis of gut microbiota has been shown to induce SALI through the mitogen-activated protein kinase/nuclear transcription factorκB (MAPK/NF-κB) signaling pathway and damage to the intestinal barrier. Meanwhile, fecal microbiota transplantation (FMT) and the application of probiotics have great potential in the treatment of SALI. This paper reviews the relevant research progress in recent years both at home and abroad, in order to provide new insights into the pathogenesis and treatment of SALI.
Craniopharyngioma-related hypothalamic obesity (CHO) has become a key issue in postoperative management of craniopharyngioma. Modified low calorie diet and exercise interventions have been found by some studies to be effective in relieving CHO, and suggested to be used as non-pharmacological treatments for weight management of craniopharyngioma patients. However, there are few relevant studies in China. We reviewed the latest developments in prevalence, hazards and risk factors as well as diet and exercise interventions towards CHO, in order to improve the outcomes and quality of life of CHO patients. In addition, we put forward recommendations on comprehensively improving the quality of life of CHO patients, such as making efforts to value CHO clinically, carrying out prospective studies on weight control in CHO, and developing rigorous diet and exercise interventions.
A large number of studies have confirmed that endoplasmic reticulum stress (ERS) is closely related to the development and progression of liver diseases, but the mechanism of the association between ERS and liver disease progression has not been clarified and needs to be further explored. Numerous studies have found that moderate ERS can activate the unfolded protein response (UPR) to protect cells, while severe or persistent ERS can induce apoptosis. Therefore, exploring the role of ERS in the pathogenesis of liver diseases may help to discover new therapeutic strategies. This paper describes the current research status and potential therapeutic strategies of ERS and UPR in various liver diseases.
