Abstract: Heart failure patients are prone to depression，and interact with each other，leading to lower quality of life and poor prognosis of patients. As the largest microecosystem in the human body，changes in the composition，structure and function of the gut microbiota are closely related to the physiological and pathological states of the host. Currently，the “gut heart/brain axis” has been used to explain the link between gut microbiota，cardiovascular diseases，and mood states，which is an important comorbid basis for heart failure and depression. In this paper，we reviewed the mechanisms of gut microbiota，metabolites，and vagus nerve in the development of heart failure and depression，and propose that mediterranean diet，probiotics，and microbiota transplantation have the potential to improve the “microbiota-gut-heart/brain axis”，providing a new perspective for the treatment of heart failure patients comorbid with depression.

Key words: Heart failure, Depression, Gut microbiota, Metabolite, Review

摘要： 心力衰竭患者容易罹患抑郁，二者相互影响，导致患者生活质量降低与预后不良。肠道菌群作为人体最大的微生态系统，其组成、结构及功能变化与宿主的生理和病理状态密切相关。目前，“肠-心/脑轴”已用于解释肠道微生物、血管疾病及情绪状态之间的联系，是心力衰竭与抑郁的重要共病基础。本文综述了肠道微生物、代谢产物、迷走神经等在心力衰竭与抑郁发生发展中的作用机制，提出地中海饮食、益生菌、菌群移植等具有改善微生物-肠-心/脑轴的潜力，为心衰共病抑郁患者的治疗提供了新的切入点。

关键词: 心力衰竭, 抑郁, 肠道菌群, 代谢产物, 综述