Chinese General Practice ›› 2025, Vol. 28 ›› Issue (34): 4337-4343.DOI: 10.12114/j.issn.1007-9572.2024.0489

• Article·Focus on Chronic Disease Comorbidity • Previous Articles     Next Articles

The Prevalence of Multimorbidity and Complex Multimorbidity in Patients with Chronic Diseases and Patterns in Urumqi City, 2016-2022

  

  1. 1. Department of Epidemiology and Health Statistics, School of Public Health, Xinjiang Medical University, Urumqi 830054, China
    2. Medical Engineering Technology College of Xinjiang Medical University, Urumqi 830054, China
    3. The First People's Hospital of Urumqi, Urumqi 830002, China
    4. Department of General Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China
    5. Urumqi Center for Disease Control and Prevention/Municipal Health Supervision, Urumqi 830022, China
  • Received:2025-02-28 Revised:2025-06-22 Published:2025-12-05 Online:2025-10-21
  • Contact: LU Yaoqin

2016—2022年乌鲁木齐市慢性病患者共病及复杂共病流行情况与共病模式研究

  

  1. 1.830054 新疆维吾尔自治区乌鲁木齐市,新疆医科大学公共卫生学院
    2.830054 新疆维吾尔自治区乌鲁木齐市,新疆医科大学医学工程技术学院
    3.830002 新疆维吾尔自治区乌鲁木齐市第一人民医院感染管理科
    4.830011 新疆维吾尔自治区乌鲁木齐市,新疆医科大学第一附属医院全科医学科
    5.830026 新疆维吾尔自治区乌鲁木齐市疾病预防控制中心 乌鲁木齐市卫生监督所
  • 通讯作者: 卢耀勤
  • 作者简介:

    作者贡献:

    周燚然提出主要研究目标,负责研究的构思与设计、研究的实施、论文撰写;周燚然、苏银霞、殷峰、武云进行数据的收集与整理、统计学处理、图表绘制与展示;周燚然、古丽加衣娜·艾肯进行论文的修订;卢耀勤负责文章的质量控制与审查,对文章整体负责,监督管理。

  • 基金资助:
    新疆维吾尔自治区自然科学基金杰出青年科学基金项目(2024D01E29); 新疆维吾尔自治区研究生科研创新项目(XJ2024G170)

Abstract:

Background

Currently, the prevalence of multimorbidity among patients with chronic diseases in China is increasing, resulting in a growing burden of disease. However, research on complex multimorbidity is relatively limited in China, underscoring an urgent need for a substantial body of evidence to inform the development of comprehensive and coordinated strategies for the control of persistent impacts of multimorbidity and complex multimorbidity.

Objective

The present study aims to investigate the prevalence of, and patterns of, multimorbidity and complex multimorbidity among patients with chronic diseases in Urumqi City between 2016 and 2022.

Methods

In June 2023, a comprehensive data set encompassing general demographic information and the prevalence of chronic diseases among patients with 27 chronic diseases was retrieved from the Urumqi City Public Health Surveillance Database and Electronic Medical Record Information Database from 2016 to 2022. The prevalence trends of multimorbidity (suffering from≥2 chronic diseases) and complex multimorbidity (suffering from ≥3 chronic diseases) in patients with chronic diseases were analyzed. Multifactorial logistic regression was used to This analysis sought to elucidate the factors that influence the occurrence of both chronic disease multimorbidity and complex multimorbidity. Additionally, the Apriori association rule algorithm was employed to identify the common patterns underlying chronic disease multimorbidity and complex multimorbidity.

Results

A total of 45 150 cases of study subjects were included during the seven-year period, comprising 12 969 (28.72%) cases of patients with a single chronic disease and 27 992 (62.00%) cases of patients with Additionally, 4 189 cases (9.28%) were identified as patients with complex multimorbidity, and the mean number of concomitant diseases per patient increased from (1.73±0.86) to (2.56±1.15). The results of the multifactorial Logistic regression analysis indicated that advancing age, male gender, and urban residence were significant risk factors for the development of comorbidities and complex multimorbidity in patients with chronic diseases. Of the 27 chronic diseases included in the study, the top three chronic disease prevalence rates were 33 675 cases of hypertension (74.58%), 32 942 cases of dyslipidemia (72.96%) and 12 408 cases of diabetes mellitus (27.48%). The most common binary co-morbidity patterns were "dyslipidemia+hypertension" "diabetes+hypertension" and "diabetes+dyslipidemia". The most common ternary co-morbidity patterns were "dyslipidemia+diabetes mellitus+hypertension" "oronary heart disease+dyslipidemia+hypertension" and "dyslipidemia+renal cyst+hypertension". Coronary heart disease was the preceding disease in all directional association rules. All rules appeared as antecedent diseases. The circulatory system was the most common co-occurring system, and the antecedents of several association rules directed to the circulatory system were all related to the endocrine system.

Conclusion

The prevalence of chronic disease multimorbidity and complex multimorbidity in Urumqi City has been increasing annually, with age, gender, and urban/rural differences playing a significant role. Hypertension, dyslipidemia, and diabetes mellitus are the most prevalent multimorbidity, while the most affected organ systems are the circulatory, digestive, and endocrine systems. The most common aggregation pattern is cardiometabolic disease.

Key words: Multimorbidity, Complex multimorbidity, Association rule, Multimorbidity pattern

摘要:

背景

目前我国慢性病患者共病数目不断攀升,疾病负担日益加重,但关于复杂共病的研究较为有限,亟须通过大量研究来获取证据,以制定综合、协调的策略来控制共病及复杂共病的持续影响。

目的

探讨2016—2022年乌鲁木齐市慢性病患者的共病和复杂共病流行情况及共病模式。

方法

于2023年6月,通过乌鲁木齐市公共卫生监测数据库和电子病历信息库收集2016—2022年27种慢性病患者的一般人口学信息和慢性病患病信息。分析慢性病患者共病(患≥2种慢性病)和复杂共病(患≥3种慢性病)的流行趋势,采用多因素Logistic回归分析慢性病共病和复杂共病的影响因素,采用Apriori关联规则算法分析慢性病共病和复杂共病的常见模式。

结果

7年间共纳入慢性病患者45 150例次,包括单一慢性病患者12 969例次(28.72%)、2种慢性病共病患者27 992例次(62.00%)、复杂共病患者4 189例次(9.28%),患者平均累积患病数由2016年的(1.73±0.86)种增至2022年的(2.56±1.15)种。多因素Logistic回归分析显示,年龄增加、男性、城市人口是慢性病患者发生共病及复杂共病的危险因素(P<0.05)。纳入的27种慢性病中,患病率居于前3位的分别为高血压33 675例次(74.58%)、血脂异常32 942例次(72.96%)、糖尿病12 408例次(27.48%)。常见二元共病模式为"血脂异常+高血压""糖尿病+高血压""糖尿病+血脂异常",常见三元共病模式为"血脂异常+糖尿病+高血压""冠心病+血脂异常+高血压""血脂异常+肾囊肿+高血压",冠心病在具有方向性的关联规则中均作为前项疾病出现。循环系统是最常见的共现系统,多条指向循环系统的关联规则中,前项均涉及内分泌系统。

结论

乌鲁木齐市慢性病共病及复杂共病发生率逐年上升且与年龄、性别、城乡分布密切相关;高血压、血脂异常、糖尿病是常见的共病因子,循环系统、消化系统、内分泌系统是常见的共病系统,心脏代谢性疾病为常见的聚集模式。

关键词: 慢性病共病, 复杂共病, 关联规则, 共病模式