Symptom clusters refers to two or more than two symptoms occurring at the same time and influencing each other. At present, symptom clusters in gastric cancer patients receiving chemotherapy obtained from different studies are not same, and there is a certain heterogeneity, which is not conducive to the management and intervention of symptom clusters.

To identify the characteristics, composition and assess the current research status of the symptom clusters of gastric cancer patients receiving chemotherapy, and to provide valuable insights for future studies on symptom clusters.

Following the PRISMA extended list of scope review report as the methodological framework, a literature search was performed in the PubMed, Web of Science, Medline, CINAHL, CNKI, Wanfang Data, VIP and SinoMed databases to identify relevant studies about symptom clusters in patients with gastric cancer from inception until May 24, 2023. The included studies were thoroughly analyzed to extract pertinent information.

A total of 12 articles were included. The elements of identifying symptom clusters included symptom assessment and analysis methods. There were 20 kinds of symptom clusters during chemotherapy. Before chemotherapy, the symptom clusters of disease, the symptom clusters digestive tract, the symptom clusters of emotional, the symptom clusters of stomach specific and the symptom clusters of nervous system appearing. After the first chemotherapy, the symptom clusters of physical, the symptom clusters of image change and the symptom clusters of energy deficiency appearing. After the 3rd chemotherapy, the type and composition of symptom clusters after chemotherapy were the most complex. After the 6th chemotherapy, the symptom clusters of chemotherapy would appear.

During receiving chemotherapy, the gastric cancer patient experienced a variety of symptom clusters with dynamic change, which changes with the progression of chemotherapy stage. Future research can explore the gastric cancer patients with specific symptom assessment tools, combined with the symptoms of advanced analysis technology such as network analysis, to accurately identify symptoms clusters at an early stage and build the symptoms of precise management solution.

症状群是指2种或2种以上的症状同时发生且互相影响，目前不同研究调查所得的胃癌患者化疗症状群不尽相同，存在一定的异质性，不利于症状群的管理和干预。

对胃癌患者化疗期间症状群的相关研究进行范围综述，以确定症状群的种类和构成及其研究现状，为今后症状群研究提供参考。

以范围综述报告的PRISMA扩展版清单为方法学框架，计算机检索PubMed、Web of Science、Medline、CINAHL、中国知网、万方数据知识服务平台、维普网和中国生物医学文献数据库中有关胃癌患者化疗期间症状群的相关研究，检索时限为建库至2023-05-24。提取和分析纳入文献的信息内容。

共纳入12篇文献，症状群的研究方法包括症状的评估方法和症状群的提取分析。胃癌患者在化疗期间涉及20种症状群，化疗前即可出现病感症状群、情绪症状群、消化道症状群、胃癌特异症状群和神经系统相关性症状群。第1次化疗后，还会出现肢体相关症状群、形象改变症状群和能量缺乏症状群。第3次化疗后，症状群的类型和构成最为复杂。第6次化疗后，则会出现化疗相关症状群。

胃癌患者在化疗期间存在多种症状群，并随化疗阶段进展发生动态变化。未来可探索胃癌患者特异性症状评估工具，结合症状网络分析等先进分析技术，以早期准确识别症状群，构建精准化的症状管理方案。