Research Progress of Anxiety and Depression Related to Chronic Fatigue Syndrome

doi:10.12114/j.issn.1007-9572.2023.0218

Abstract

Abstract:

The relationship between fatigue and diseases continues to receive widespread attention and fatigue is becoming an important public health issue. The World Health Organization added overexertion to the International Classification of Diseases in May, 2019, which had took effect globally in 2022. The concept of chronic fatigue syndrome (CFS) was proposed earlier, while its etiology and pathogenesis still remain unclear till now, resulting in lacking of specific therapies, which may be due to the involvement of multiple systems and the difficulties in distinguishing CFS symptoms from anxiety/depression, the complexity of the diagnosis and treatment of the disease and researches on it are also increased. This review initially investigates the characteristics of CFS associated with anxiety/depression, further explores the similarities and differences in indicator change characteristics between CFS and anxiety/depression in terms of the current research status on biological indicators, imaging abnormalities and treatment, in order to provide new ideas for the diagnosis and typing of CFS, and provide suggestions for conducting clinical and basic researches on the disease.

Key words: Fatigue syndrome, chronic, Anxiety, Depression, Neuroendocrine system, Immunity, Inflammation, Oxidative stress, Brain function, Review

摘要：

疾病与疲劳的关系持续受到广泛关注，且疲劳已成为重要的公共卫生问题，2019年5月世界卫生组织将"过劳"列入《国际疾病分类》中，并于2022年在全球生效。慢性疲劳综合征（CFS）则是更早提出的疾病概念，到目前为止，该病的病因和发病机制尚不清楚，也缺乏特异性的治疗方法。主要原因除了该病涉及多个系统外，其症状表现还通常与焦虑、抑郁难以区分，这也明显增加了该病诊疗及研究的复杂性。本文结合现有的研究文献，初步探讨了CFS与焦虑、抑郁的相关研究特点，从生物学指标研究现状、影像学异常和治疗等方面，进一步探讨了CFS的指标变化特征与焦虑、抑郁的异同点，旨在为CFS诊断及分型提供新的思路，并为开展该病的临床和基础研究提供建议。

关键词: 疲劳综合征, 慢性, 焦虑, 抑郁, 神经内分泌系统, 免疫, 炎症, 氧化性应激, 脑功能, 综述

LIU Xinyi,LIU Zhandong. Research Progress of Anxiety and Depression Related to Chronic Fatigue Syndrome[J]. Chinese General Practice, 2023, 26(35): 4477-4482. DOI: 10.12114/j.issn.1007-9572.2023.0218.
刘欣怡,刘占东. 慢性疲劳综合征相关焦虑及抑郁的研究进展[J]. 中国全科医学, 2023, 26(35): 4477-4482. DOI: 10.12114/j.issn.1007-9572.2023.0218.

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