Spinal degenerative diseases are currently most common clinical conditions and also dominant diseases in the field of traumatology and orthopedics. Traditional Chinese manipulative therapy is a common approach for spinal degenerative diseases in traumatology and orthopedics of Chinese medicine. However, the current researches on the efficacy mechanism of traditional Chinese manipulative therapy is still not deep enough, which hinders the modernization and internationalization of the study on the manipulative therapy. Combination of medicine and industry is a novel research idea generated by the combination of relevant scientific and technological progress and the modernization of traditional Chinese medicine in recent years, which is helpful to realize the modernization of the research on the efficacy mechanism of traditional Chinese manipulative therapy and promote the internationalization of traditional Chinese manipulative therapy. Using the application status of modern engineering technologies such as mechanical engineering technology, software engineering technology, neural engineering technology and artificial intelligence technology in the research of traditional Chinese manipulative therapy as research ideas, this paper sorts out the researches on the modernization on the efficacy mechanism of traditional Chinese manipulation under the "combination of medicine and industry" research model in recent years, in order to provide reference ideas for the subsequent researches of the efficacy mechanism of manipulation in the treatment of spinal degenerative diseases.

脊柱退行性疾病是目前骨伤科临床较为常见的病种之一，也是中医骨伤科学的主要优势病种。中医手法是中医骨伤科学治疗该类疾病的常用手段，但现阶段中医手法疗效机制研究仍不够深入，阻碍了手法研究的现代化进程与国际化推广。医工结合是近年来相关科学技术进步与中医药现代化需求相结合而产生的全新研究思路，有助于实现中医手法疗效机制研究现代化，促进中医手法的国际化推广。本文将从机械工程技术、软件工程技术、神经工程技术及人工智能技术等现代工程技术在中医手法中的应用现状为思路，梳理近年来"医工结合"研究模式下中医手法疗效机制的现代化研究，为后续手法治疗脊柱退行性疾病的疗效机制研究提供参考。