Nanoparticle- and Exosome-based Targeted Drug Delivery Systems Used in the Diagnosis and Treatment of Atherosclerosis: Opportunities and Challenges

doi:10.12114/j.issn.1007-9572.2022.0795

Abstract

Abstract:

Atherosclerosis is a chronic inflammatory disease in which atheromatous plaque long-termly accumulates and obstructs the intima of medium and large arteries, causing first severe stenosis and blood flow disorders, and then ischemia and hypoxia in tissues and organs. Nanomedicines have received widespread attention for their unique advantages over conventional drugs in the treatment of atherosclerosis. This article detailedly reviews several nanoparticle- and exosome-based targeted drug delivery systems in anti-atherosclerosis research, briefly describes the synthesis of representative nanomaterials, analyses their targeting properties and outlines the benefits and inherent challenges of nanomedicines. Despite the challenges that need to be addressed and refined, nanoparticles and exosomes used as drug delivery vehiclesin treatments for atherosclerosis hold great promise and are expected to have wider clinical applications.

Key words: Atherosclerosis, Cardiovascular diseases, Nanoparticles, Exosomes, Inflammation, Targeted therapy

摘要：

动脉粥样硬化是一种慢性炎症性疾病，粥样斑块慢性聚集并沉积于大中型动脉内膜，导致严重的狭窄和血运障碍，引发组织器官缺血缺氧。纳米药物相对于传统药物在动脉粥样硬化治疗中因其具有独特的优势而广泛受到关注。本文重点综述几种纳米靶向颗粒（系统）和外泌体靶向载药系统在抗动脉粥样硬化研究中的应用，简述代表性纳米材料的合成过程，对其靶向性进行分析，并概述纳米药物的益处和内在挑战。尽管面临着一些需要解决和完善的挑战，但是纳米颗粒和外泌体靶向载药治疗的前景广阔，并有望将其推广应用于临床实践中。

关键词: 动脉粥样硬化, 心血管疾病, 纳米颗粒, 外泌体, 炎症, 靶向治疗

LIU Taotao,LI Tianrong,WANG Xue, et al. Nanoparticle- and Exosome-based Targeted Drug Delivery Systems Used in the Diagnosis and Treatment of Atherosclerosis: Opportunities and Challenges[J]. Chinese General Practice, 2023, 26(08): 903-910. DOI: 10.12114/j.issn.1007-9572.2022.0795.
刘滔滔,李天容,王雪等. 纳米颗粒和外泌体靶向载药系统诊治动脉粥样硬化的机遇与挑战[J]. 中国全科医学, 2023, 26(08): 903-910. DOI: 10.12114/j.issn.1007-9572.2022.0795.

Figures/Tables 1

References 61

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纳米粒子	类型	粒径（nm）	药物	实验模型	靶点	报道时间（年）
RP-PU	膜包裹纳米颗粒	239.2±5.40	普罗布考	ApoE^-/-小鼠	斑块内ROS	2022^[18]
CDNPs	金属纳米粒子	388±34	2-羟丙基-β-环糊精	ApoE^-/-小鼠	动脉粥样硬化斑块	2022^[19]
RAP@T/R NPs	复合纳米粒子	274.9	雷帕霉素	ApoE^-/-小鼠	变中组织蛋白酶K酶	2022^[20]
MP-QT-NP	脂质体	105	槲皮素	ApoE^-/-小鼠		2022^[21]
CD9-HMSN@RSV	介孔二氧化硅纳米颗粒	100~150	瑞舒伐他汀	ApoE^-/-小鼠	CD9高表达的衰老细胞	2021^[22]
MM/RAPNPs	膜包裹纳米颗粒	90	雷帕霉素	ApoE^-/-小鼠	动脉粥样硬化斑块	2021^[23]
L-NPs	脂质体	88.7±1.4	—	LDLR^-/-小鼠	巨噬细胞内膜上CD36受体	2021^[24]
HASF@CUR	纳米胶束	150.8	姜黄素	HFD大鼠	巨噬细胞内的活性氧	2020^[25]
argo-switching nanoparticles （CSNP）	核-壳结构纳米颗粒	104±13	甲基-β-环糊精和辛伐他汀	ApoE^-/-小鼠和HFD小鼠	动脉粥样斑块胆固醇	2020^[26]
Leuko-Rapa	"Leukosomes"	108±2.3	雷帕霉素	ApoE^-/-小鼠	动脉粥样斑块下内皮细胞	2020^[27]
HA-NPs	复合纳米粒子	90	—	ApoE^-/-小鼠	动脉粥样斑块下内皮细胞	2019^[28]
IL10-NC	金属纳米粒子	81±16	IL-10	ApoE^-/-小鼠	斑块新生血管中过表达的αvβ3整合素	2020^[29]
TPCD NP	复合纳米粒子	128±1	Tempol	ApoE^-/-小鼠	巨噬细胞	2018^[30]
1cM-PFAG	复合纳米粒子	215±31	阿魏酸	HMDMs	巨噬细胞	2017^[31]

纳米粒子	类型	粒径（nm）	药物	实验模型	靶点	报道时间（年）
RP-PU	膜包裹纳米颗粒	239.2±5.40	普罗布考	ApoE^-/-小鼠	斑块内ROS	2022^[18]
CDNPs	金属纳米粒子	388±34	2-羟丙基-β-环糊精	ApoE^-/-小鼠	动脉粥样硬化斑块	2022^[19]
RAP@T/R NPs	复合纳米粒子	274.9	雷帕霉素	ApoE^-/-小鼠	变中组织蛋白酶K酶	2022^[20]
MP-QT-NP	脂质体	105	槲皮素	ApoE^-/-小鼠		2022^[21]
CD9-HMSN@RSV	介孔二氧化硅纳米颗粒	100~150	瑞舒伐他汀	ApoE^-/-小鼠	CD9高表达的衰老细胞	2021^[22]
MM/RAPNPs	膜包裹纳米颗粒	90	雷帕霉素	ApoE^-/-小鼠	动脉粥样硬化斑块	2021^[23]
L-NPs	脂质体	88.7±1.4	—	LDLR^-/-小鼠	巨噬细胞内膜上CD36受体	2021^[24]
HASF@CUR	纳米胶束	150.8	姜黄素	HFD大鼠	巨噬细胞内的活性氧	2020^[25]
argo-switching nanoparticles （CSNP）	核-壳结构纳米颗粒	104±13	甲基-β-环糊精和辛伐他汀	ApoE^-/-小鼠和HFD小鼠	动脉粥样斑块胆固醇	2020^[26]
Leuko-Rapa	"Leukosomes"	108±2.3	雷帕霉素	ApoE^-/-小鼠	动脉粥样斑块下内皮细胞	2020^[27]
HA-NPs	复合纳米粒子	90	—	ApoE^-/-小鼠	动脉粥样斑块下内皮细胞	2019^[28]
IL10-NC	金属纳米粒子	81±16	IL-10	ApoE^-/-小鼠	斑块新生血管中过表达的αvβ3整合素	2020^[29]
TPCD NP	复合纳米粒子	128±1	Tempol	ApoE^-/-小鼠	巨噬细胞	2018^[30]
1cM-PFAG	复合纳米粒子	215±31	阿魏酸	HMDMs	巨噬细胞	2017^[31]