Advances in the Use of Regional Homogeneity from Resting-state Functional MRI for the Diagnosis of Insomnia in Depressive Disorder

doi:10.12114/j.issn.1007-9572.2022.0443

Abstract

Abstract:

Insomnia is a common concomitant symptom in patients with depressive disorder. Early and effective assessment of insomnia symptoms in these patients is the key to preventing sleep problems and delaying the deterioration of depression disorder. Currently, the effectiveness of subjective and objective sleep assessment tools has often been expounded in relevant reviews, but the assessment indicators related to insomnia in depressive disorder, and rs-fMRI technique, an objective sleep assessment tool, have been rarely reviewed. We reviewed the latest advances in the use of regional homogeneity from resting-state functional MRI for the diagnosis of insomnia in major depressive disorder, and described its use in the differentiation between unipolar and bipolar disorders, with a view to providing theoretical and practical evidence for clinical diagnosis, differentiation, and treatment of unipolar and bipolar disorders, and for relevant studies.

Key words: Sleep initiation and maintenance disorders, Insomnia, Depression, fMRI, ReHo, Review

摘要：

在抑郁障碍患者中，失眠是常见的伴发症状。早期有效评估抑郁障碍患者的失眠症状是预防患者睡眠问题与抑郁障碍进一步恶化的关键。目前关于睡眠评估工具的综述仅说明了主客观评估工具的效用，极少综述指出与抑郁障碍伴失眠症状相关的评估指标，也很少围绕静息态功能磁共振成像（rs-fMRI）技术作为睡眠状况的客观评估工具进行阐述。因此，本文就用于抑郁障碍伴发失眠症状患者的rs-fMRI局部一致性进行阐述，并指出目前研究单相抑郁障碍（UDD）和双相抑郁障碍（BDD）患者之间在rs-fMRI局部一致性的区别，以期为临床上UDD与BDD患者的诊断、鉴别、治疗及相关研究提供理论基础和实用性参考。

关键词: 入睡和睡眠障碍, 失眠症, 抑郁, 静息态功能磁共振成像, 局部一致性, 综述

CHEN Pinqi,ZHANG Liqing,XIANG Ting, et al. Advances in the Use of Regional Homogeneity from Resting-state Functional MRI for the Diagnosis of Insomnia in Depressive Disorder[J]. Chinese General Practice, 2022, 25(35): 4462-4467. DOI: 10.12114/j.issn.1007-9572.2022.0443.
陈品琪,张丽清,向婷等. 静息态功能磁共振局部一致性在抑郁障碍伴失眠症状患者中的研究进展[J]. 中国全科医学, 2022, 25(35): 4462-4467. DOI: 10.12114/j.issn.1007-9572.2022.0443.

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