Chinese General Practice ›› 2022, Vol. 25 ›› Issue (12): 1499-1505.DOI: 10.12114/j.issn.1007-9572.2021.02.092
Special Issue: 安全用药最新文章合集
• Medication Analysis • Previous Articles Next Articles
Received:
2021-09-13
Revised:
2021-10-25
Published:
2021-11-18
Online:
2022-03-21
Contact:
Wenbin FAN
About author:
通讯作者:
樊文彬
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2021.02.092
上市PAMORA | 上市时间 | 常规用法 | 常见不良反应 | 使用注意事项 |
---|---|---|---|---|
纳洛西醇 | 2014年9月 | 口服:25 mg/次,1次/d,如不耐受则剂量减半 | 腹痛、腹泻、恶心、胀气、呕吐、头痛等 | 合并肠梗阻患者禁用;禁与CYP3A4强抑制剂合用 |
羟考酮/纳洛酮缓释片剂 | 2014年7月 | 口服:10 mg/5 mg/次,1次/12 h | 恶心、呕吐等 | 合并肝损伤、肠梗阻、呼吸抑制、支气管哮喘患者禁用 |
甲基纳曲酮 | 2009年11月 | 口服:450 mg/次,1次/早;皮下注射:12 mg/次,1次/d | 腹痛、腹泻、头痛、腹胀、呕吐、多汗、焦虑等 | 合并肠梗阻患者禁用;中重度肝、肾功能不全者减量使用 |
纳德米定 | 2017年3月 | 口服:0.2 mg/次,1次/d | 腹痛、腹泻、恶心 | 合并肠梗阻患者禁用;重度肝功能不全者不推荐使用;避免与CYP3A4抑制剂同用 |
阿维莫潘 | 2008年5月 | 术前30 min~5 h口服12 mg,术后口服12 mg/次,2次/d,持续7 d | 贫血、消化不良、低钾血症、背痛、尿潴留 | 尚未被批准用于治疗OIC |
Table 1 Marketing time,general usage,common adverse reactions and precautions of marketed PAMORA
上市PAMORA | 上市时间 | 常规用法 | 常见不良反应 | 使用注意事项 |
---|---|---|---|---|
纳洛西醇 | 2014年9月 | 口服:25 mg/次,1次/d,如不耐受则剂量减半 | 腹痛、腹泻、恶心、胀气、呕吐、头痛等 | 合并肠梗阻患者禁用;禁与CYP3A4强抑制剂合用 |
羟考酮/纳洛酮缓释片剂 | 2014年7月 | 口服:10 mg/5 mg/次,1次/12 h | 恶心、呕吐等 | 合并肝损伤、肠梗阻、呼吸抑制、支气管哮喘患者禁用 |
甲基纳曲酮 | 2009年11月 | 口服:450 mg/次,1次/早;皮下注射:12 mg/次,1次/d | 腹痛、腹泻、头痛、腹胀、呕吐、多汗、焦虑等 | 合并肠梗阻患者禁用;中重度肝、肾功能不全者减量使用 |
纳德米定 | 2017年3月 | 口服:0.2 mg/次,1次/d | 腹痛、腹泻、恶心 | 合并肠梗阻患者禁用;重度肝功能不全者不推荐使用;避免与CYP3A4抑制剂同用 |
阿维莫潘 | 2008年5月 | 术前30 min~5 h口服12 mg,术后口服12 mg/次,2次/d,持续7 d | 贫血、消化不良、低钾血症、背痛、尿潴留 | 尚未被批准用于治疗OIC |
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