Molecular Mechanism of Oxidative Stress
Mediated Androgen Receptor Signal Reactivation in Prostatic Cancer Progression

doi:10.12114/j.issn.1007-9572.2021.01.114

Abstract

Abstract:

After androgen-deprivation therapy, a large amount of reactive oxygen species are produced in patients with advanced prostate cancer (PCa) to aggravate oxidative stress. This article explains the different molecular mechanisms by which oxidative stress regulates the androgenreceptor and its signaling pathways, such as oxidative stress mediated transcription factors induce AR expression, leading to increased local androgen levels in tumors; increased AR sensitivity leads to decreased level of testosterone and induce the bypass via AR activation, in order to explore the molecular mechanism of PCa evolution to castration-resistant prostate cancer, providing new ideas for the prevention, diagnosis and treatment of castration-resistant prostate cancer.

Key words: Prostatic neoplasms, Reactive oxygen species, Oxdative stress, Receptors, androgen, Prostate cancer, Castration-resistant prostate cancer, Signaling pathway, Review

摘要：

晚期前列腺癌患者经过去势治疗后，体内产生大量的活性氧加重氧化应激。本文阐述了氧化应激调节雄激素受体（AR）及其信号通路的不同分子机制，例如氧化应激介导转录因子诱导AR过表达，导致瘤内局部雄激素水平升高，增加AR对低水平雄激素的敏感性以及诱导旁路途经导致AR激活，进而探究前列腺癌向去势抵抗性前列腺癌演进的分子机制，为势抵抗性前列腺癌的预防、诊断、治疗提供新的思路。

关键词: 前列腺肿瘤, 活性氧, 氧化应激, 受体, 雄激素, 前列腺癌, 去势抵抗性前列腺癌, 信号通路, 综述

CLC Number:

R737.25

HENG Li, ZHANG Liguo, DONG Jingting, LI Zhiguo, CAO Fenghong.

Molecular Mechanism of Oxidative Stress Mediated Androgen Receptor Signal Reactivation in Prostatic Cancer Progression [J]. Chinese General Practice, 2022, 25(05): 636-642.

衡立,张立国,董婧婷等. 氧化应激介导雄激素受体信号重激活在前列腺癌演进中的分子机制研究进展[J]. 中国全科医学, 2022, 25(05): 636-642. DOI: 10.12114/j.issn.1007-9572.2021.01.114.

Figures/Tables 2

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