Latest Research Development in Histone
Acetylation in the Pathogenesis of Asthma

doi:10.12114/j.issn.1007-9572.2021.01.015

Abstract

Abstract:

Asthma is primarily marked by airway hyperresponsiveness, inflammation, and remodeling. Histone acetylation is one of the most common epigenetic modifications that regulates histone acetyltransferase and histone deacetylase, and imbalanced regulation may lead to pathological changes. We reviewed the advances in histone acetylation in the pathogenesis of asthma in recent five years, revealing the direction of systematic and in-depth research, in order to provide evidence for clinical treatment.

Key words: Asthma, Histone acetylation, Histone acetyltransferase, Histone deacetylase, Review

摘要：

哮喘主要以气道炎症、气道重塑和气道高反应性为特征。组蛋白乙酰化是最常见的表观遗传修饰之一，主要指组蛋白乙酰转移酶和组蛋白去乙酰化酶的调节，调节失衡会导致病理变化。该文回顾论述了近5年来组蛋白乙酰化修饰在哮喘发病机制中的研究，揭示系统和深入研究的发展方向，旨在为临床治疗提供依据。

关键词: 哮喘, 组蛋白乙酰化, 组蛋白酰基转移酶, 组蛋白去乙酰化酶, 综述

CLC Number:

R562.25

CHEN Shaopeng, ZENG Minjuan, LAI Tianwen.

Latest Research Development in Histone Acetylation in the Pathogenesis of Asthma [J]. Chinese General Practice, 2022, 25(05): 631-635.

陈绍鹏,曾敏娟,赖天文. 组蛋白乙酰化修饰在哮喘发病机制中的研究进展[J]. 中国全科医学, 2022, 25(05): 631-635. DOI: 10.12114/j.issn.1007-9572.2021.01.015.

Figures/Tables 1

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