Abstract: Background　Cancer mortality rate in China has increased significantly in recent years with vast geographic disparities.Along with accelerated urbanization-induced great changes in living environment and lifestyle，variation has been found in cancer mortality profile in suburban residents，which deserves great attention.Objective　To explore the epidemiological characteristics and trends of cancer associated deaths in a community in Shanghai's Pudong New Area from 2010 to 2016，providing guidances for the development of intervention measures．Methods　This study was conducted between June and November 2018.Data about causes of death during 2010—2016 stemmed from Liuzao Community part of Pudong New Area death records database.Causes of death were coded based on the 2010 International Classification of Diseases （ICD-10），in which codes for cancers range from C00 to C97.Primary outcomes are crude and standardized mortality rate，potential years of life lost （PYLL），PYLL rate and average years of life lost （AYLL）．Results　The crude cancer mortality rate showed a year-over-year increasing trend 〔annual percentage change （APC）=5.44%，Z=2.750，P=0.040）〕．The standardized mortality rate showed an increasing trend during 2010—2013 （APC=13.00%，Z=4.380，P=0.048），in contrast，no obvious changes were observed during 2013—2016 （APC=-4.74%，Z=-1.740，P=0.224）．During 2010—2016，the crude cancer mortality rate was higher among males than that of females （u=5.60，P<0.001）．There was an increasing trend in the crude cancer mortality rate among males （APC=6.79%，Z=3.383，P=0.020）．The increasing trend of standardized mortality rate for males was not statistically significant （APC=1.57%，Z=0.572，P=0.591）．There was no apparent changes in the crude cancer mortality rate for females （APC=1.27%，Z=0.996，P=0.365）．The standardized mortality rate for females showed an increasing trend （APC=7.54%，Z=2.843，P=0.036）．The PYLL，PYLL rate，and AYLL were 2 865.20 person years，11.72‰，and 5.32 years per person，respectively.PYLL showed an increasing trend （APC=6.79%，Z=3.383，P=0.019），but AYLL showed no apparent trend of changes （APC=1.27%，Z=0.996，P=0.394）．Conclusion　There was an increasing trend in the crude cancer mortality and PYLL due to cancer in the study community.The results suggest that we need to improve the implementation of targeted cancer prevention and control programs，and to further promote early detection of cancer in the community.

Key words: Neoplasms, Death, Mortality, Potential years of life lost, Epidemiology

摘要： 背景　近年来我国恶性肿瘤死亡率显著上升且有明显地区差异，随着城市化进程的加快，生活环境与习惯发生巨大变化的城市郊区居民恶性肿瘤死因谱的变化值得重点关注。目的　了解2010—2016年上海市某社区居民恶性肿瘤相关死亡流行病学特点及其趋势，为制定相关的干预措施提供依据。方法　2018年6—11月，以上海市浦东新区六灶社区户籍人口为研究对象，死因资料来源于浦东新区2010—2016年户籍人口死亡数据库。死因分类根据2010年国际疾病分类第10版（ICD-10）统一编码，其中恶性肿瘤的ICD-10编码范围包括C00-97，以粗死亡率、标化死亡率、潜在减寿年数（PYLL）、PYLL率、平均减寿年数（AYLL）为主要分析指标。结果　恶性肿瘤粗死亡率呈现逐年上升的趋势〔年度变化百分比（APC）=5.44%，Z=2.750，P=0.040〕；2010—2013年恶性肿瘤标化死亡率呈上升趋势（APC=13.00%，Z=4.380，P=0.048）；2013—2016年恶性肿瘤标化死亡率无明显变化（APC=-4.74%，Z=-1.740，P=0.224）。2010—2016年男性恶性肿瘤粗死亡率高于女性（u=5.60，P<0.001）；男性恶性肿瘤粗死亡率呈上升趋势（APC=6.79%，Z=3.383，P=0.020），标化死亡率无明显变化（APC=1.57%，Z=0.572，P=0.591）；女性恶性肿瘤粗死亡率无明显变化（APC=1.27%，Z=0.996，P=0.365），标化死亡率呈上升趋势（APC=7.54%，Z=2.843，P=0.036）。2010—2016年恶性肿瘤PYLL为2 865.20人年，PYLL率为11.72‰，AYLL为5.32年/人；PYLL呈现逐年上升趋势（APC=6.79%，Z=3.383，P=0.019），AYLL无明显变化趋势（APC=1.27%，Z=0.996，P=0.394）。结论　该社区恶性肿瘤粗死亡率及PYLL呈现逐年上升的趋势，提示应加强针对的恶性肿瘤的防控措施，深入推进恶性肿瘤社区早发现工作。

关键词: 肿瘤, 死亡, 死亡率, 潜在减寿年数, 流行病学