Abstract: Secondary bone malignancy is the disease of bone damage and pain，which is caused by the metastasis of malignant tumor originating outside bone tissue through blood. Secondary bone malignancy can cause Skeletal Related events such as pain，pathological fractures，spinal cord compression and hypercalcemia，which seriously affect the quality of life of patients with advanced malignant tumors. Therefore，the formal and comprehensive diagnosis and treatment of secondary bone malignancy combined with traditional Chinese and western medicine is of great significance for the clinical treatment of secondary bone malignancy and its complications. The purpose of this Guide is to summarize the basis of traditional Chinese and Western medicinediagnosis and treatment of secondary bone malignancy by searching and analyzing relevant evidence at home and abroad，and to provide decision-making basis for the diagnosis and treatment of patients with secondary malignant tumors of bone causing pain and bone destruction.This guideline was jointly formulated by the Cancer Hospital of the Chinese Academy of Medical Sciences and Peking Union Medical College，in collaboration with experts from relevant fields from 24 medical institutions across the country，including Dongzhimen Hospital of Beijing University of Chinese Medicine，China-Japan Friendship Hospital，and Guang 'anmen Hospital of the China Academy of Chinese Medical Sciences. The guideline formulation work is based on the current situation of integrated traditional Chinese and Western medicine diagnosis and treatment practice of secondary malignant tumors of bone at home and abroad. It systematically reviews the relevant literature evidence and reaches a consensus through multiple rounds of expert argumentation. This guideline systematically sorts out the definition，etiology，diagnosis and treatment strategies of secondary malignant tumors of bone，aiming to provide evidence-based basis for the clinical diagnosis of this disease and the formulation of integrated traditional Chinese and Western medicine treatment plans，in order to standardize clinical practice.

Key words: Neoplasms, second primary；Bone neoplasms；Integrated Traditional Chinese Medicine & Western Medicine；Diagnosis；Guidebook

摘要： 骨继发恶性肿瘤是由原发于骨组织以外的恶性肿瘤经血行转移至骨组织引起的以骨损害、疼痛为主要表现的疾病。骨继发恶性肿瘤可致疼痛、病理性骨折、脊髓压迫和高钙血症等骨相关事件，这些症状严重影响恶性肿瘤晚期患者的生活质量。进行正规全面综合的骨继发恶性肿瘤中西医结合诊疗，对于临床治疗骨继发恶性肿瘤及其并发症具有十分重要的意义。本指南由中国医学科学院北京协和医学院肿瘤医院牵头，联合北京中医药大学东直门医院、中日友好医院、中国中医科学院广安门医院等全国 24 家医疗机构的相关领域专家共同制定。指南制定工作基于当前国内外骨继发恶性肿瘤中西医结合诊疗实践的现状，系统回顾了相关文献证据，并通过多轮专家论证达成共识。本指南系统梳理了骨继发恶性肿瘤的定义、病因、诊断及治疗策略，旨在为该疾病的临床诊断及中西医结合治疗方案的制定提供循证依据，以规范临床实践。

关键词: 肿瘤, 继发原发性；骨肿瘤；中西医结合；诊断；指南