
Chinese General Practice ›› 2025, Vol. 28 ›› Issue (08): 996-1003.DOI: 10.12114/j.issn.1007-9572.2024.0519
Special Issue: 老年问题最新文章合辑; 老年人群健康最新文章合辑
• Original Research·Epidemiological Study • Previous Articles Next Articles
Received:2024-10-20
Revised:2024-11-18
Published:2025-03-15
Online:2025-01-02
Contact:
CHEN Hongru
通讯作者:
陈虹汝
作者简介:作者贡献:
任义涛提出研究思路和研究方案,撰写论文;韩树奎负责检索GBD 2021数据库,进行数据整理、统计分析、图表绘制、论文修改;宋盼盼、马金祥负责对数据资料进行二次校对;马昕、张紫钰负责论文的质量控制及审校,对论文最终版本进行修订;陈虹汝负责对科研过程全程把控。全部作者已确认论文终稿。
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2024.0519
| 指标 | 全国 | 男性 | 女性 | |||
|---|---|---|---|---|---|---|
| AAPC(95%CI) | P值 | AAPC(95%CI) | P值 | AAPC(95%CI) | P值 | |
| 发病率 | 0.57(0.41~0.72) | <0.001 | 0.63(0.59~0.67) | <0.001 | 0.60(0.45~0.75) | <0.001 |
| 患病率 | 0.64(0.60~0.68) | <0.001 | 0.66(0.62~0.70) | <0.001 | 0.68(0.48~0.87) | <0.001 |
| 死亡率 | -0.05(-0.15~0.06) | 0.368 | 0.12(0.04~0.19) | 0.003 | -0.09(-0.20~0.02) | 0.119 |
| DALY率 | 0.09(-0.01~0.19) | 0.088 | 0.20(0.12~0.29) | <0.001 | 0.10(-0.02~0.21) | 0.095 |
Table 1 Epidemiological trends of ADRD in the elderly population in China from 1992 to 2021
| 指标 | 全国 | 男性 | 女性 | |||
|---|---|---|---|---|---|---|
| AAPC(95%CI) | P值 | AAPC(95%CI) | P值 | AAPC(95%CI) | P值 | |
| 发病率 | 0.57(0.41~0.72) | <0.001 | 0.63(0.59~0.67) | <0.001 | 0.60(0.45~0.75) | <0.001 |
| 患病率 | 0.64(0.60~0.68) | <0.001 | 0.66(0.62~0.70) | <0.001 | 0.68(0.48~0.87) | <0.001 |
| 死亡率 | -0.05(-0.15~0.06) | 0.368 | 0.12(0.04~0.19) | 0.003 | -0.09(-0.20~0.02) | 0.119 |
| DALY率 | 0.09(-0.01~0.19) | 0.088 | 0.20(0.12~0.29) | <0.001 | 0.10(-0.02~0.21) | 0.095 |
| 指标 | 全国 | 男性 | 女性 | |||
|---|---|---|---|---|---|---|
| 年份(年) | APC(95%CI)(%) | 年份(年) | APC(95%CI)(%) | 年份(年) | APC(95%CI)(%) | |
| 发病率 | ||||||
| 1992—1996 | 1.28(0.86~1.70) | 1992—1995 | 1.46(1.30~1.62) | 1992—1996 | 1.37(0.97~1.77) | |
| 1996—2011 | 0.03(-0.03~0.09) | 1995—2005 | 0.35(0.32~0.38) | 1996—2011 | -0.002(-0.06~0.06) | |
| 2011—2015 | 1.42(0.76~2.09) | 2005—2010 | -0.21(-0.30~-0.11) | 2011—2015 | 1.44(0.80~2.07) | |
| 2015—2019 | -0.18(-0.83~0.48) | 2010—2015 | 1.50(1.40~1.60) | 2015—2019 | -0.10(-0.72~0.53) | |
| 2019—2021 | 3.01(1.67~4.36) | 2015—2019 | -0.31(-0.47~-0.15) | 2019—2021 | 3.35(2.06~4.65) | |
| 2019—2021 | 2.58(2.26~2.90) | |||||
| 患病率 | ||||||
| 1992—1995 | 1.69(1.54~1.83) | 1992—1995 | 1.60(1.45~1.76) | 1992—1996 | 1.60(1.08~2.12) | |
| 1995—2005 | 0.27(0.24~0.30) | 1995—2005 | 0.40(0.37~0.43) | 1996—2011 | 0.02(-0.06~0.09) | |
| 2005—2010 | -0.41(-0.50~-0.32) | 2005—2010 | -0.19(-0.28~-0.09) | 2011—2015 | 1.53(0.71~2.35) | |
| 2010—2015 | 1.37(1.28~1.46) | 2010—2015 | 1.43(1.33~1.53) | 2015—2019 | -0.24(-1.05~0.57) | |
| 2015—2019 | -0.26(-0.40~-0.12) | 2015—2019 | -0.40(-0.55~-0.25) | 2019—2021 | 4.00(2.33~5.70) | |
| 2019—2021 | 3.59(3.29~3.88) | 2019—2021 | 2.92(2.61~3.24) | |||
| 死亡率 | ||||||
| 1992—2005 | -0.11(-0.16~-0.05) | 1992—2019 | -0.06(-0.08~-0.04) | 1992—2019 | -0.24(-0.27~-0.21) | |
| 2005—2013 | -0.41(-0.56~-0.25) | 2019—2021 | -2.45(1.29~3.63) | 2019—2021 | 1.97(0.30~3.67) | |
| 2013—2019 | -0.08(-0.34~0.18) | |||||
| 2019—2021 | 1.96(0.78~3.15) | |||||
| DALY率 | ||||||
| 1992—2019 | -0.08(-0.11~-0.05) | 1992—2019 | 0.05(0.03~0.08) | 1992—2019 | -0.08(-0.11~-0.05) | |
| 2019—2021 | 2.39(0.84~3.97) | 2019—2021 | 2.26(1.02~3.53) | 2019—2021 | 2.47(0.78~4.19) | |
Table 2 Epidemiological changes of ADRD in the elderly population in China from 1992 to 2021
| 指标 | 全国 | 男性 | 女性 | |||
|---|---|---|---|---|---|---|
| 年份(年) | APC(95%CI)(%) | 年份(年) | APC(95%CI)(%) | 年份(年) | APC(95%CI)(%) | |
| 发病率 | ||||||
| 1992—1996 | 1.28(0.86~1.70) | 1992—1995 | 1.46(1.30~1.62) | 1992—1996 | 1.37(0.97~1.77) | |
| 1996—2011 | 0.03(-0.03~0.09) | 1995—2005 | 0.35(0.32~0.38) | 1996—2011 | -0.002(-0.06~0.06) | |
| 2011—2015 | 1.42(0.76~2.09) | 2005—2010 | -0.21(-0.30~-0.11) | 2011—2015 | 1.44(0.80~2.07) | |
| 2015—2019 | -0.18(-0.83~0.48) | 2010—2015 | 1.50(1.40~1.60) | 2015—2019 | -0.10(-0.72~0.53) | |
| 2019—2021 | 3.01(1.67~4.36) | 2015—2019 | -0.31(-0.47~-0.15) | 2019—2021 | 3.35(2.06~4.65) | |
| 2019—2021 | 2.58(2.26~2.90) | |||||
| 患病率 | ||||||
| 1992—1995 | 1.69(1.54~1.83) | 1992—1995 | 1.60(1.45~1.76) | 1992—1996 | 1.60(1.08~2.12) | |
| 1995—2005 | 0.27(0.24~0.30) | 1995—2005 | 0.40(0.37~0.43) | 1996—2011 | 0.02(-0.06~0.09) | |
| 2005—2010 | -0.41(-0.50~-0.32) | 2005—2010 | -0.19(-0.28~-0.09) | 2011—2015 | 1.53(0.71~2.35) | |
| 2010—2015 | 1.37(1.28~1.46) | 2010—2015 | 1.43(1.33~1.53) | 2015—2019 | -0.24(-1.05~0.57) | |
| 2015—2019 | -0.26(-0.40~-0.12) | 2015—2019 | -0.40(-0.55~-0.25) | 2019—2021 | 4.00(2.33~5.70) | |
| 2019—2021 | 3.59(3.29~3.88) | 2019—2021 | 2.92(2.61~3.24) | |||
| 死亡率 | ||||||
| 1992—2005 | -0.11(-0.16~-0.05) | 1992—2019 | -0.06(-0.08~-0.04) | 1992—2019 | -0.24(-0.27~-0.21) | |
| 2005—2013 | -0.41(-0.56~-0.25) | 2019—2021 | -2.45(1.29~3.63) | 2019—2021 | 1.97(0.30~3.67) | |
| 2013—2019 | -0.08(-0.34~0.18) | |||||
| 2019—2021 | 1.96(0.78~3.15) | |||||
| DALY率 | ||||||
| 1992—2019 | -0.08(-0.11~-0.05) | 1992—2019 | 0.05(0.03~0.08) | 1992—2019 | -0.08(-0.11~-0.05) | |
| 2019—2021 | 2.39(0.84~3.97) | 2019—2021 | 2.26(1.02~3.53) | 2019—2021 | 2.47(0.78~4.19) | |
| 效应 | 发病率 | 患病率 | ||||
|---|---|---|---|---|---|---|
| 男性 | 女性 | 全国 | 男性 | 女性 | 全国 | |
| 年龄(岁) | ||||||
| 60~64 | 0.21(0.20~0.21) | 0.19(0.19~0.19) | 0.19(0.19~0.20) | 0.22(0.21~0.22) | 0.19(0.19~0.19) | 0.20(0.20~0.20) |
| 65~69 | 0.30(0.30~0.30) | 0.32(0.32~0.32) | 0.31(0.31~0.31) | 0.33(0.33~0.33) | 0.31(0.31~0.32) | 0.31(0.31~0.31) |
| 70~74 | 0.52(0.52~0.52) | 0.59(0.59~0.59) | 0.55(0.55~0.55) | 0.51(0.51~0.52) | 0.53(0.53~0.53) | 0.51(0.51~0.51) |
| 75~79 | 1.04(1.04~1.05) | 1.14(1.14~1.15) | 1.09(1.09~1.09) | 0.92(0.92~0.92) | 0.97(0.97~0.97) | 0.93(0.93~0.93) |
| 80~84 | 1.75(1.74~1.75) | 1.77(1.76~1.77) | 1.76(1.76~1.76) | 1.57(1.57~1.57) | 1.65(1.65~1.65) | 1.61(1.61~1.61) |
| 85~89 | 2.31(2.29~2.32) | 2.15(2.14~2.15) | 2.23(2.22~2.24) | 2.28(2.27~2.28) | 2.30(2.30~2.31) | 2.32(2.32~2.32) |
| 90~94 | 2.65(2.63~2.68) | 2.44(2.42~2.45) | 2.58(2.56~2.59) | 2.77(2.76~2.78) | 2.75(2.75~2.76) | 2.85(2.84~2.85) |
| ≥95 | 2.78(2.73~2.83) | 2.57(2.55~2.59) | 2.75(2.73~2.77) | 2.98(2.96~3.00) | 3.05(3.04~3.05) | 3.21(3.20~3.22) |
| 时期(年) | ||||||
| 1992—1996 | 0.77(0.76~0.77) | 0.78(0.77~0.78) | 0.77(0.77~0.78) | 0.77(0.76~0.77) | 0.77(0.77~0.77) | 0.77(0.77~0.77) |
| 1997—2001 | 0.86(0.85~0.86) | 0.87(0.87~0.88) | 0.87(0.86~0.87) | 0.86(0.86~0.86) | 0.86(0.86~0.86) | 0.86(0.86~0.86) |
| 2002—2006 | 0.96(0.95~0.96) | 0.96(0.95~0.96) | 0.96(0.95~0.96) | 0.95(0.95~0.96) | 0.95(0.95~0.95) | 0.95(0.95~0.95) |
| 2007—2011 | 1.04(1.03~1.04) | 1.03(1.02~1.03) | 1.03(1.03~1.03) | 1.04(1.04~1.04) | 1.03(1.02~1.03) | 1.03(1.03~1.03) |
| 2012—2016 | 1.18(1.17~1.18) | 1.16(1.15~1.16) | 1.16(1.16~1.17) | 1.18(1.17~1.18) | 1.17(1.17~1.17) | 1.17(1.17~1.17) |
| 2017—2021 | 1.30(1.29~1.31) | 1.30(1.29~1.30) | 1.30(1.30~1.31) | 1.31(1.30~1.31) | 1.32(1.32~1.32) | 1.32(1.32~1.32) |
| 队列(年) | ||||||
| 1897—1901 | 1.71(1.59~1.84) | 1.66(1.61~1.71) | 1.68(1.64~1.73) | 1.63(1.58~1.68) | 1.66(1.64~1.68) | 1.66(1.64~1.68) |
| 1902—1906 | 1.52(1.47~1.57) | 1.51(1.48~1.53) | 1.52(1.50~1.54) | 1.50(1.48~1.52) | 1.54(1.53~1.55) | 1.54(1.53~1.55) |
| 1907—1911 | 1.38(1.35~1.42) | 1.40(1.38~1.41) | 1.41(1.39~1.42) | 1.39(1.38~1.41) | 1.43(1.42~1.43) | 1.43(1.42~1.43) |
| 1912—1916 | 1.28(1.26~1.30) | 1.29(1.28~1.30) | 1.30(1.29~1.31) | 1.28(1.27~1.29) | 1.30(1.30~1.30) | 1.31(1.30~1.31) |
| 1917—1921 | 1.17(1.16~1.19) | 1.17(1.16~1.18) | 1.18(1.17~1.19) | 1.18(1.17~1.19) | 1.19(1.18~1.19) | 1.19(1.19~1.19) |
| 1922—1926 | 1.07(1.06~1.08) | 1.07(1.06~1.07) | 1.07(1.06~1.07) | 1.09(1.08~1.09) | 1.09(1.09~1.09) | 1.09(1.09~1.09) |
| 1927—1931 | 0.99(0.98~0.99) | 0.98(0.97~0.98) | 0.98(0.98~0.98) | 1.01(1.00~1.01) | 1.00(1.00~1.00) | 1.00(1.00~1.00) |
| 1932—1936 | 0.91(0.91~0.92) | 0.90(0.90~0.90) | 0.90(0.90~0.90) | 0.93(0.93~0.93) | 0.92(0.92~0.92) | 0.92(0.92~0.92) |
| 1937—1941 | 0.85(0.85~0.85) | 0.84(0.84~0.85) | 0.84(0.84~0.84) | 0.86(0.85~0.86) | 0.85(0.85~0.85) | 0.85(0.85~0.85) |
| 1942—1946 | 0.78(0.78~0.79) | 0.80(0.79~0.80) | 0.78(0.78~0.79) | 0.78(0.78~0.78) | 0.78(0.78~0.78) | 0.78(0.78~0.78) |
| 1947—1951 | 0.72(0.71~0.72) | 0.74(0.74~0.74) | 0.73(0.72~0.73) | 0.72(0.72~0.72) | 0.71(0.71~0.72) | 0.71(0.71~0.71) |
| 1952—1956 | 0.66(0.66~0.67) | 0.68(0.67~0.68) | 0.67(0.67~0.67) | 0.66(0.66~0.66) | 0.64(0.64~0.65) | 0.65(0.65~0.65) |
| 1957—1961 | 0.61(0.60~0.62) | 0.60(0.60~0.61) | 0.60(0.60~0.61) | 0.60(0.60~0.61) | 0.58(0.57~0.58) | 0.58(0.58~0.59) |
Table 3 Age-period-cohort model analysis results of ADRD in China
| 效应 | 发病率 | 患病率 | ||||
|---|---|---|---|---|---|---|
| 男性 | 女性 | 全国 | 男性 | 女性 | 全国 | |
| 年龄(岁) | ||||||
| 60~64 | 0.21(0.20~0.21) | 0.19(0.19~0.19) | 0.19(0.19~0.20) | 0.22(0.21~0.22) | 0.19(0.19~0.19) | 0.20(0.20~0.20) |
| 65~69 | 0.30(0.30~0.30) | 0.32(0.32~0.32) | 0.31(0.31~0.31) | 0.33(0.33~0.33) | 0.31(0.31~0.32) | 0.31(0.31~0.31) |
| 70~74 | 0.52(0.52~0.52) | 0.59(0.59~0.59) | 0.55(0.55~0.55) | 0.51(0.51~0.52) | 0.53(0.53~0.53) | 0.51(0.51~0.51) |
| 75~79 | 1.04(1.04~1.05) | 1.14(1.14~1.15) | 1.09(1.09~1.09) | 0.92(0.92~0.92) | 0.97(0.97~0.97) | 0.93(0.93~0.93) |
| 80~84 | 1.75(1.74~1.75) | 1.77(1.76~1.77) | 1.76(1.76~1.76) | 1.57(1.57~1.57) | 1.65(1.65~1.65) | 1.61(1.61~1.61) |
| 85~89 | 2.31(2.29~2.32) | 2.15(2.14~2.15) | 2.23(2.22~2.24) | 2.28(2.27~2.28) | 2.30(2.30~2.31) | 2.32(2.32~2.32) |
| 90~94 | 2.65(2.63~2.68) | 2.44(2.42~2.45) | 2.58(2.56~2.59) | 2.77(2.76~2.78) | 2.75(2.75~2.76) | 2.85(2.84~2.85) |
| ≥95 | 2.78(2.73~2.83) | 2.57(2.55~2.59) | 2.75(2.73~2.77) | 2.98(2.96~3.00) | 3.05(3.04~3.05) | 3.21(3.20~3.22) |
| 时期(年) | ||||||
| 1992—1996 | 0.77(0.76~0.77) | 0.78(0.77~0.78) | 0.77(0.77~0.78) | 0.77(0.76~0.77) | 0.77(0.77~0.77) | 0.77(0.77~0.77) |
| 1997—2001 | 0.86(0.85~0.86) | 0.87(0.87~0.88) | 0.87(0.86~0.87) | 0.86(0.86~0.86) | 0.86(0.86~0.86) | 0.86(0.86~0.86) |
| 2002—2006 | 0.96(0.95~0.96) | 0.96(0.95~0.96) | 0.96(0.95~0.96) | 0.95(0.95~0.96) | 0.95(0.95~0.95) | 0.95(0.95~0.95) |
| 2007—2011 | 1.04(1.03~1.04) | 1.03(1.02~1.03) | 1.03(1.03~1.03) | 1.04(1.04~1.04) | 1.03(1.02~1.03) | 1.03(1.03~1.03) |
| 2012—2016 | 1.18(1.17~1.18) | 1.16(1.15~1.16) | 1.16(1.16~1.17) | 1.18(1.17~1.18) | 1.17(1.17~1.17) | 1.17(1.17~1.17) |
| 2017—2021 | 1.30(1.29~1.31) | 1.30(1.29~1.30) | 1.30(1.30~1.31) | 1.31(1.30~1.31) | 1.32(1.32~1.32) | 1.32(1.32~1.32) |
| 队列(年) | ||||||
| 1897—1901 | 1.71(1.59~1.84) | 1.66(1.61~1.71) | 1.68(1.64~1.73) | 1.63(1.58~1.68) | 1.66(1.64~1.68) | 1.66(1.64~1.68) |
| 1902—1906 | 1.52(1.47~1.57) | 1.51(1.48~1.53) | 1.52(1.50~1.54) | 1.50(1.48~1.52) | 1.54(1.53~1.55) | 1.54(1.53~1.55) |
| 1907—1911 | 1.38(1.35~1.42) | 1.40(1.38~1.41) | 1.41(1.39~1.42) | 1.39(1.38~1.41) | 1.43(1.42~1.43) | 1.43(1.42~1.43) |
| 1912—1916 | 1.28(1.26~1.30) | 1.29(1.28~1.30) | 1.30(1.29~1.31) | 1.28(1.27~1.29) | 1.30(1.30~1.30) | 1.31(1.30~1.31) |
| 1917—1921 | 1.17(1.16~1.19) | 1.17(1.16~1.18) | 1.18(1.17~1.19) | 1.18(1.17~1.19) | 1.19(1.18~1.19) | 1.19(1.19~1.19) |
| 1922—1926 | 1.07(1.06~1.08) | 1.07(1.06~1.07) | 1.07(1.06~1.07) | 1.09(1.08~1.09) | 1.09(1.09~1.09) | 1.09(1.09~1.09) |
| 1927—1931 | 0.99(0.98~0.99) | 0.98(0.97~0.98) | 0.98(0.98~0.98) | 1.01(1.00~1.01) | 1.00(1.00~1.00) | 1.00(1.00~1.00) |
| 1932—1936 | 0.91(0.91~0.92) | 0.90(0.90~0.90) | 0.90(0.90~0.90) | 0.93(0.93~0.93) | 0.92(0.92~0.92) | 0.92(0.92~0.92) |
| 1937—1941 | 0.85(0.85~0.85) | 0.84(0.84~0.85) | 0.84(0.84~0.84) | 0.86(0.85~0.86) | 0.85(0.85~0.85) | 0.85(0.85~0.85) |
| 1942—1946 | 0.78(0.78~0.79) | 0.80(0.79~0.80) | 0.78(0.78~0.79) | 0.78(0.78~0.78) | 0.78(0.78~0.78) | 0.78(0.78~0.78) |
| 1947—1951 | 0.72(0.71~0.72) | 0.74(0.74~0.74) | 0.73(0.72~0.73) | 0.72(0.72~0.72) | 0.71(0.71~0.72) | 0.71(0.71~0.71) |
| 1952—1956 | 0.66(0.66~0.67) | 0.68(0.67~0.68) | 0.67(0.67~0.67) | 0.66(0.66~0.66) | 0.64(0.64~0.65) | 0.65(0.65~0.65) |
| 1957—1961 | 0.61(0.60~0.62) | 0.60(0.60~0.61) | 0.60(0.60~0.61) | 0.60(0.60~0.61) | 0.58(0.57~0.58) | 0.58(0.58~0.59) |
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