Advances in Energy Metabolism Regulation of Intestinal Stem Cell Function and the Therapeutic Advantages of Traditional Chinese Medicine

doi:10.12114/j.issn.1007-9572.2023.0676

Abstract

Abstract:

Intestinal stem cells are an important part of maintaining the stability of intestinal barrier function, which is closely related to intestinal homeostasis, intestinal epithelial renewal, and repair of intestinal damage. Normal physiological activities of the human body cannot be separated from energy intake and metabolism, and the differentiation fate of stem cells is affected by energy metabolism, and impaired intestinal barrier is associated with the development of many intestinal diseases. Therefore, this paper focuses on intestinal stem cells, takes energy metabolism and metabolites as the background to investigate how energy metabolism and metabolites regulate the function and activity of stem cells, thus regulating the function of intestinal barrier and providing ideas for the treatment of various intestinal diseases; in addition, with the in-depth research of modern medical science in protecting intestinal barrier, the theory of traditional Chinese medicine (TCM) that cares for spleen and stomach is gradually showing its scientific validity, with the hope of providing ideas for the subsequent research.

Key words: Intestinal stem cells, Energy metabolism, Intestinal diseases, Traditional Chinese medicine, Review

摘要：

肠道干细胞是维持肠道屏障功能稳定的一个重要部分，与肠道稳态、肠道上皮更新、肠道损伤的修复密切相关。人体正常生理活动离不开能量的摄入与代谢，干细胞的分化命运受能量代谢的影响，且肠道屏障受损与多种肠道疾病的发生发展有关。故本文以肠道干细胞为中心，以能量代谢及代谢物为背景，探究能量代谢及代谢物如何调控干细胞功能和活性，从而调节肠道屏障功能，为多种肠道疾病的治疗提供思路；此外，随着现代医学在保护肠道屏障方面研究的深入，中医讲求"顾护脾胃"的理论逐渐显示出科学性，以期为后续的研究提供思路。

关键词: 肠道干细胞, 能量代谢, 肠道疾病, 中医药, 综述

ZHU Yan,XIAO Jin,YANG Yang, et al. Advances in Energy Metabolism Regulation of Intestinal Stem Cell Function and the Therapeutic Advantages of Traditional Chinese Medicine[J]. Chinese General Practice, 2024, 27(23): 2853-2857. DOI: 10.12114/j.issn.1007-9572.2023.0676.
朱焰,肖瑾,杨阳等. 能量代谢调控肠道干细胞功能研究进展及中医药治疗优势初探[J]. 中国全科医学, 2024, 27(23): 2853-2857. DOI: 10.12114/j.issn.1007-9572.2023.0676.

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