Recent Developments in Pituitary-directed Medical Treatment for Cushing's Disease

doi:10.12114/j.issn.1007-9572.2021.01.039

Abstract

Abstract:

Cushing's disease is caused by excessive secretion of adrenocorticotropic hormone (ACTH) by hormone-secreting pituitary adenomas, the first-choice treatment for which is surgical resection of the pituitary adenoma. Medication therapy is the second-line treatment, and a necessary treatment for some patients with unsatisfactory surgical results or failing to use the surgery. With recent developments in pathogenesis studies of Cushing's disease, medications specifically targeting hormone-secreting pituitary adenomas have proven to be effective in controlling the tumor growth, and suppressing the tumor's secretion of ACTH, which may be a theoretical and practical basis for medical treatment of Cushing's disease. In this review, we discussed pituitary-directed medical therapies for Cushing's disease and their mechanisms of actions, aiming to increase medical workers' understanding of this disease, and to offer theoretical evidence for the development of appropriate treatment strategies.

Key words: Cushing syndrome, Adrenocorticotropic hormone, Drug therapy, Review

摘要：

由垂体促肾上腺皮质激素腺瘤分泌过多的促肾上腺皮质激素（ACTH）所致的库欣综合征又称为库欣病，其首选治疗方式为手术切除垂体腺瘤，但部分患者术后治疗效果欠佳或无法进行手术，药物治疗作为二线治疗，也是必不可少的治疗手段。近年来对库欣病发病机制的研究得到了很大进展，作用于垂体促肾上腺皮质激素腺瘤的药物既能控制肿瘤增殖也能抑制ACTH分泌，为库欣病的药物治疗奠定了理论和临床实践基础。本文致力于论述垂体促肾上腺皮质激素腺瘤导向药物及其相应作用机制，以期进一步加深对库欣病治疗的了解，为制订更有效的治疗策略提供理论参考。

关键词: 库欣综合征, 促肾上腺皮质激素, 药物疗法, 综述

Ling LI,Huijuan ZHANG. Recent Developments in Pituitary-directed Medical Treatment for Cushing's Disease[J]. Chinese General Practice, 2022, 25(14): 1789-1794. DOI: 10.12114/j.issn.1007-9572.2021.01.039.
李玲,张会娟. 作用于垂体治疗库欣病的药物研究进展[J]. 中国全科医学, 2022, 25(14): 1789-1794. DOI: 10.12114/j.issn.1007-9572.2021.01.039.

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