Recent Advances in the Relationship between Intestinal Flora and Respiratory Diseases

doi:10.12114/j.issn.1007-9572.2021.00.003

Abstract

Abstract: Intestinal flora is a large microbial community inhabiting in the intestinal tract.Studies have shown that intestinal flora plays an important role in metabolism，immune system development and inflammation in the human body，and is closely associated with diseases of digestive，immune，nervous，and respiratory systems.With the development of technologies for microbial analysis，the relationship between intestinal flora and respiratory diseases has drawn increasing attentions and concerns.The proposal of gut-lung axis provides a new idea for studying the pathogenesis and treatment of respiratory diseases.This paper reviews the correlation between intestinal and respiratory flora and their interaction with gut-lung axis，focusing on the relationship and mechanism of action of intestinal flora with respiratory diseases such as respiratory infectious diseases，airway allergic diseases，chronic obstructive pulmonary diseases，cystic fibrosis，pulmonary tuberculosis，lung cancer and so on，providing new insights into the pathogenesis research and treatment of respiratory diseases.

Key words: Intestinal microflora, Microbial consortia, Gastrointestinal microbiome, Respiratory diseases, Gut-lung axis, Review

摘要： 肠道菌群是定植在肠道内的庞大微生物群落。研究表明，肠道菌群在生物体内的新陈代谢、免疫系统发育、炎性反应等方面发挥着重要作用，与消化系统、免疫系统、神经系统、呼吸系统等疾病密切相关。随着微生物分析技术的发展，肠道菌群与呼吸系统疾病之间的关系受到越来越多的关注和重视，“肠-肺轴”的提出更为呼吸系统疾病的发病机制研究和治疗手段提供了新的思路。本文综述了肠道和呼吸道菌群的相关性以及与肠-肺轴之间的交互作用，重点介绍了肠道菌群与呼吸道感染性疾病、气道过敏性疾病、慢性阻塞性肺疾病、囊性纤维化、肺结核、肺癌等呼吸系统疾病之间的关系和作用机制，以期为呼吸系统疾病的发病机制研究和治疗提供新的思路。

关键词: 肠道菌群, 微生物群落, 肠道微生态, 呼吸系统疾病, 肠-肺轴, 综述

XIAO Siyao,ZHANG Shunan. Recent Advances in the Relationship between Intestinal Flora and Respiratory Diseases　[J]. Chinese General Practice, 2021, 24(9): 1165-1172. DOI: 10.12114/j.issn.1007-9572.2021.00.003.
肖锶瑶,张纾难. 肠道菌群和呼吸系统疾病相关性的研究进展[J]. 中国全科医学, 2021, 24(9): 1165-1172. DOI: 10.12114/j.issn.1007-9572.2021.00.003.

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