Abstract: Background As one of the main causes of children's disability， cerebral palsy（ hereinafter referred to as CP） affects the improvement of our population quality.At present， the results of researches on the prevalence of children suffering from CP inour country are quite different， and there is a lack of epidemiological studies based on larger sample sizes and the current prevalence of CP.Objective To learn about the prevalence of CP in children aged 0-6 in China.Methods Literatures on the prevalence of CP in children aged 0-6 in China were retrievaled through computer in PubMed， Web of Science， The Cochrane Library， China National Knowledge Infrastructure（ CNKI） ， Wanfang Data Knowledge Service System， VIP Database（ VIP） ， and China Biology Medicine disc（ CBM） ， and the publication date limited from January 1st to January 1st， 2020.Based on established inclusion criteria， literatures were screened.Meta-analysis was performed on the included literatures with Stata 12.0 software， the prevalence was quantitatively combined， and subgroup analysis was carried out on classification indicators， such as gender and age.Results This study finally included 8 papers of medium or above quality，with a total of 527 758 people， including 1 022 CP children.The results of Meta-analysis proved that the overall prevalence of CP among children aged 0 to 6 in China was 0.23%〔 95%CI（ 0.17%， 0.29%）〕 .The subgroup analysis results revealed that the prevalence of boys was 0.22%〔 95%CI（ 0.14%， 0.29%） 〕 ， the prevalence of girls was 0.12%〔 95%CI（ 0.06%， 0.19%） 〕 . The prevalence of CP among children at the ages of below one years， one years， two years， three years， four years， five years， and six years was 0.21%〔 95%CI （ 0.02%， 0.40%）〕， 0.20%〔 95%CI （ 0.10%， 0.30%）〕， 0.19%〔 95%CI （ 0.08%， 0.30%）〕，0.21%〔 95%CI（ 0.09%， 0.32%） 〕 ， 0.13%〔 95%CI（ 0.02%， 0.24%） 〕 ， 0.20%〔 95%CI（ 0.09%， 0.32%） 〕 ， 0.32%〔 95%CI （ 0.14%， 0.50%）〕， respectively.Conclusion The prevalence of CP in children aged 0 to 6 in China was 0.23%， and the prevalence of gender and age was different， guiding significance for policy formulation and clinical intervention.It is recommended to conduct more cross-sectional investigations based on the new classification of CP.

Key words: Cerebral palsy, Children, Prevalence, Epidemiology, Meta-analysis

摘要： 背景　脑性瘫痪（以下简称脑瘫）是导致儿童残疾的主要原因之一，同时影响我国人口素质的提高。目前，我国对儿童脑瘫患病率的研究结果差异较大，缺乏基于较大样本量和较新的儿童脑瘫的流行病学研究。目的　了解较新的中国0~6岁儿童脑瘫患病情况。方法　计算机检索PubMed、Web of Science、The Cochrane Library、中国知网、万方数据知识服务系统、维普网和中国生物医学文献数据库（CBM）发表的关于中国0~6岁儿童脑瘫流行病学研究的文献，检索时限为2015-01-01至2020-01-01。收集纳入文献中调查对象的样本量、调查地区、性别、年龄、患儿例数等信息，并对纳入的文献运用Stata 12.0软件进行Meta分析，对患病率进行定量合并，并对性别、年龄等分类指标进行亚组分析。结果　共纳入文献8篇，文献质量均为中等及以上，调查对象共527 758例，其中脑瘫患儿1 022例。Meta分析结果显示，中国0~6岁儿童脑瘫总患病率为0.23%〔95%CI（0.17%，0.29%）〕；亚组分析结果显示，男童脑瘫患病率为0.22%〔95%CI（0.14%，0.29%）〕，女童脑瘫患病率为0.12%〔95%CI（0.06%，0.19%）〕；<1、1、2、3、4、5、6岁儿童脑瘫患病率分别为0.21%〔95%CI（0.02%，0.40%）〕、0.20%〔95%CI（0.10%，0.30%）〕、0.19%〔95%CI（0.08%，0.30%）〕、0.21%〔95%CI（0.09%，0.32%）〕、0.13%〔95%CI（0.02%，0.24%）〕、0.20%〔95%CI（0.09%，0.32%）〕、0.32%〔95%CI（0.14%，0.50%）〕。结论　中国0~6岁儿童脑瘫患病率为0.23%，性别和年龄段的患病率均表现不同，对于政策制定、临床干预有指导意义，建议依据新的脑瘫分型进行更多横断面研究。

关键词: 大脑性瘫痪, 儿童, 患病率, 流行病学, Meta分析