Anxiety and Depression Prevalence in Chinese Patients with Gastroesophageal Reflux Disease：a Meta-analysis

doi:10.12114/j.issn.1007-9572.2021.00.080

Abstract

Key words: Gastroesophageal reflux, Anxiety, Depression, Prevalence, Epidemiology, Meta analysis

摘要： 背景　胃食管反流病（GERD）是一种常见的消化系统疾病，在全球呈高发趋势，给患者造成严重的心理负担。GERD与患者的焦虑抑郁密切相关，因此，准确地了解GERD患者的精神状态将有助于更好地进行诊治。但是，目前尚缺乏此方面基于中国人群的系统性分析。目的　通过Meta分析的方法系统评价中国GERD患者焦虑抑郁患病情况。方法　通过计算机检索中国生物医学文献服务系统、中国知网、万方数据知识服务平台、维普网、PubMed等数据库，检索时间为2000年1月—2020年5月，收集关于中国GERD患者焦虑抑郁患病情况的调查研究。采用Stata 12.0、Revman 5.1软件对焦虑抑郁患病率进行Meta分析。结果　共纳入17篇文献，90 537例受调查者，文献质量整体较好。Meta分析结果显示，GERD患者焦虑患病率为41%〔95%CI（31%，51%）〕，反流性食管炎（RE）患者焦虑患病率为36%〔95%CI（25%，48%）〕，非糜烂性胃食管反流病（NERD）患者焦虑患病率为51%〔95%CI（44%，58%）〕。GERD患者抑郁患病率为37%〔95%CI（32%，42%）〕，RE患者抑郁患病率为34%〔95%CI（28%，39%）〕，NERD患者抑郁患病率为45%〔95%CI（23%，67%）〕。结论　中国人群GERD患者中焦虑抑郁呈高发趋势，GERD患者患焦虑抑郁的风险更大，临床工作中准确地了解GERD患者的精神状况将有助于更好地对GERD患者进行诊疗。

关键词: 胃食管反流, 焦虑, 抑郁, 患病率, 流行病学, Meta分析

ZHOU Jinchi,DOU Weijia,WEI Yan, et al. Anxiety and Depression Prevalence in Chinese Patients with Gastroesophageal Reflux Disease：a Meta-analysis　[J]. Chinese General Practice, 2021, 24(5): 608-613. DOI: 10.12114/j.issn.1007-9572.2021.00.080.
周金池,窦维佳,魏延等. 中国胃食管反流病患者焦虑抑郁患病率的Meta分析[J]. 中国全科医学, 2021, 24(5): 608-613. DOI: 10.12114/j.issn.1007-9572.2021.00.080.

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