Advances in Mechanisms Underlying the Comorbidity of Depression and Cardiovascular Disease

doi:10.12114/j.issn.1007-9572.2021.00.430

Abstract

Abstract: There are bidirectional associations between depression and cardiovascular disease （CVD）.In other words，people with depression are more likely to develop CVD than the general population and vice versa.And depression is an independent risk factor for prognosis in patients with CVD.This review summarizes epidemiological evidence on the relationship between depression and CVD，as well as the potential mechanisms of comorbidity of the two，including the influences of unhealthy lifestyle，inflammation，hypothalamic-pituitary-adrenal axis dysfunction and autonomic dysfunction.The discovery of these mechanisms may have important implications for the prevention and treatment of coexistence of depression and CVD，and may suggest that early screening and management of depression in CVD patients are very important and achievable goals.However，more studies are needed to determine the optimal management option for patients with depression and CVD.

Key words: Depressive Disorder, Cardiovascular disease, Life style, Inflammation, Hypothalamic-pituitary-adrenal axis, Heart rate variability

摘要： 抑郁症与心血管疾病之间存在着双向关联，即抑郁症患者比健康个体更易罹患心血管疾病，反之亦然，且抑郁症还是预测心血管疾病患者预后的独立危险因素。本文总结了抑郁症与心血管疾病之间关系的流行病学证据，以及二者共病的潜在发生机制，包括生活方式、炎症、下丘脑-垂体-肾上腺轴及自主神经功能障碍等，这些机制的发现可能对预防及治疗抑郁症与心血管疾病共病有着重要意义，同时也提示早期对心血管疾病患者进行抑郁症筛查、管理，是一个十分重要且可以实现的目标。但如何实现还需要大量研究来确定抑郁症与心血管疾病共病患者的最佳管理方案。

关键词: 抑郁症, 心血管疾病, 生活方式, 炎症, 下丘脑-垂体-肾上腺轴, 心率变异性

WANG Mingxin,LI Suxia,SONG Tao. Advances in Mechanisms Underlying the Comorbidity of Depression and Cardiovascular Disease　[J]. Chinese General Practice, 2021, 24(11): 1426-1430. DOI: 10.12114/j.issn.1007-9572.2021.00.430.
王明鑫,李素霞,宋涛. 抑郁症与心血管疾病共病机制的研究进展[J]. 中国全科医学, 2021, 24(11): 1426-1430. DOI: 10.12114/j.issn.1007-9572.2021.00.430.

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