Advances in Immune Characteristics and Immune Regulation in the Elderly

doi:10.12114/j.issn.1007-9572.2020.00.373

Abstract

Abstract: Distinctive physiological changes occur with aging in immune system and other human body systems.How to determine therapies to effectively boost the weakened immune system in the elderly，is a major medical challenge of the 21st century.Probiotics and thymosin，two immunity-modulators，have obtained increasing attention in terms of benefiting the immune system in the elderly.Here we reviewed the role of immunity，immune characteristics of the elderly，recent advances in immunomodulators，problems existing in current studies on immunosenescence，and the application prospect of probiotics combined with thymosin in modulating immunity in the elderly，with a view to providing clinical and theoretical basis for promoting the health of the elderly.

Key words: Immunity, Immunomodulation, Aging, Probiotics, Thymosin

摘要： 随着年龄的增长，人体生理机能发生特征性改变，老年人的免疫功能有所减弱，制定平衡老年人免疫缺陷的战略是21世纪医学的一大挑战。其中益生菌和胸腺肽对于老年人的有益作用越来越受到重视。本文综述了免疫的作用、老年人免疫系统的特点以及免疫调节剂的研究进展，阐述了免疫衰老现况研究中存在的一些问题及益生菌联合胸腺肽在老年人免疫中的应用前景，为促进老年人健康提供临床理论依据。

关键词: 免疫, 免疫调节, 衰老, 益生菌, 胸腺肽

WANG Jian,GONG Yanfeng. Advances in Immune Characteristics and Immune Regulation in the Elderly　[J]. Chinese General Practice, 2021, 24(11): 1431-1435. DOI: 10.12114/j.issn.1007-9572.2020.00.373.
王健,龚燕锋. 老年人免疫特点及免疫调节的研究进展[J]. 中国全科医学, 2021, 24(11): 1431-1435. DOI: 10.12114/j.issn.1007-9572.2020.00.373.

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