Factors Associated with Increased Risk of SARS-CoV-2 Infections in Diabetics

doi:10.12114/j.issn.1007-9572.2020.00.494

Abstract

Abstract: Novel coronavirus 2019 （COVID-19）is spreading worldwide in 2020. Previous studies showed that elderly diabetic patients are more susceptible to COVID-19 and have higher rates of severity and mortality，though the reasons for this are unclear yet. This research retrieved，the relevant articles in recent years and found that it may be related to the changes of lung structure and function， cellular and humoral immunity deficiency，angiotensin converting enzyme 2，obesity and inflammatory factors，hypercoagulability，oxidative stress，glycosylation，age and other factors in diabetic patients，but whether diabetes increases the susceptibility to COVID-19 needs to be confirmed by further research.

Key words: Diabetes mellitus, SARS-CoV-2, Coronavirus disease 2019（COVID-19）, Respiratory function tests, Lung function, Immunity deficiency, Angiotensin converting enzyme, Obesity

摘要： 2020年新型冠状病毒席卷全球，有研究显示，患有糖尿病的老年人更易受到感染，且重症率和病死率更高，但具体原因尚不清楚。本研究检索近年来的相关文献，发现其可能与糖尿病患者的肺形态及功能改变、细胞免疫和体液免疫缺陷、血管紧张素转化酶2、肥胖和炎性因子、高凝状态、氧化应激和糖基化、年龄等因素有关，但是否是糖尿病本身增加了其易感性，尚需进一步研究证实。

关键词: 糖尿病, 新型冠状病毒, 新型冠状病毒肺炎, 呼吸功能试验, 肺功能, 免疫缺陷, 血管紧张素转换酶, 肥胖

GAO Jie,GAO Yun,ZHANG Mingfeng, et al. Factors Associated with Increased Risk of SARS-CoV-2 Infections in Diabetics　[J]. Chinese General Practice, 2020, 23(35): 4436-4442. DOI: 10.12114/j.issn.1007-9572.2020.00.494.
高杰,高云,张明峰等. 糖尿病患者新型冠状病毒感染风险增加的因素分析[J]. 中国全科医学, 2020, 23(35): 4436-4442. DOI: 10.12114/j.issn.1007-9572.2020.00.494.

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