Effects of Iodine Deficiency in Pregnancy and Iodine Supplementation on Neurointellectual Development of Offspring

doi:10.12114/j.issn.1007-9572.2019.00.231

Abstract

Abstract: Iodine is a necessary trace element for the synthesis of thyroid hormone，which is crucial for human brain development and physical growth.Due to increased physiological demand for iodine during pregnancy，iodine deficiency is a common problem of malnutrition during pregnancy，which has attracted much attention.During pregnancy，especially in the first trimester，even mild and moderate iodine deficiency may cause irreversible damage to neurointellectual development and cognitive function of the offspring.However，the necessity and timing of iodine supplementation are still controversial.On the basis of literature review，we summarized recent advances in the impact of iodine deficiency during pregnancy，especially mild and moderate iodine deficiency during pregnancy on neurodevelopment in children，and in iodine supplementation，and concluded that iodine supplementation therapy should be used mainly for preventing iodine deficiency rather than curing，and maintaining optimal iodine nutrition status in pregnancy is crucial to the prevention of brain development injury of offspring.

Key words: Iodine, Pregnant women, Nervous system, Intelligence, Iodine deficiency, Thyroid hormones, Fetus

摘要： 碘是合成甲状腺激素必需的微量元素，而甲状腺激素对人体的脑发育及生长发育至关重要。由于妊娠期机体对碘的需求量明显增加，妊娠期碘缺乏已成为妊娠期营养不良的常见问题，目前备受关注。妊娠期尤其是妊娠早期，即使是轻、中度碘缺乏也可能导致后代的神经智力发育及认知功能产生不可逆性损伤，然而补充碘剂的必要性及时机还存在争议。本文回顾了相关文献，对妊娠期碘缺乏，尤其是妊娠期轻、中度碘缺乏对儿童神经智力发育的影响及补碘干预的相关研究进展进行总结，指出补碘治疗应以预防为主，妊娠期维持最佳碘营养状态对于后代神经智力发育至关重要。

关键词: 碘, 孕妇, 神经系统, 智力, 碘缺乏, 甲状腺激素类, 胎儿

ZHANG Le,BAI Yu,ZHAI Xiaodan. Effects of Iodine Deficiency in Pregnancy and Iodine Supplementation on Neurointellectual Development of Offspring　[J]. Chinese General Practice, 2019, 22(24): 2962-2966. DOI: 10.12114/j.issn.1007-9572.2019.00.231.
张乐,白宇,翟晓丹. 妊娠期碘缺乏及补碘干预对后代神经智力发育的影响[J]. 中国全科医学, 2019, 22(24): 2962-2966. DOI: 10.12114/j.issn.1007-9572.2019.00.231.

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