Rational Application of Antidepressants in Pregnancy

doi:10.12114/j.issn.1007-9572.2019.00.182

Abstract

Abstract: The study of drug use during gestation is influenced by many factors other than medical ethics.It is still one of the most easily neglected fields with the slowest development in clinical pharmacology and pharmaceutical research.Due to unique changes in maternal physiology and the vulnerability of fetal development during pregnancy，rational use of drugs in pregnancy has been widely concerned.Depression is a kind of chronic mental disease characterized by high prevalence rate，high disability rate，high recurrence rate，and high suicide rate.Therefore，the safety and necessity of antidepressant use during pregnancy in depressed women has become a major problem in clinical treatment.This paper detailedly discusses the rational application of antidepressants in pregnancy.

Key words: Pregnancy, Antidepressive agents, Embryonic and fetal development, Drug therapy, Depressive disorder

摘要： 妊娠期用药的研究受医学伦理学等因素的影响，迄今为止仍是临床药理学和药物研究发展最缓慢和最受忽视的领域之一。由于妊娠期独特的母体生理学变化和胎儿发育的易损性，使得妊娠期妇女的合理用药问题被广泛关注。抑郁症是一种慢性精神疾病，具有患病率高、致残率高、复发率高和自杀率高等特点，因此抑郁症妇女妊娠期抗抑郁药物应用的安全性及必要性，成为临床治疗面临的一大难题。本文主要就妊娠期抗抑郁药物的合理应用进行
详述。

关键词: 妊娠, 抗抑郁药, 胚胎和胎儿发育, 药物疗法, 抑郁症

ZHAI Qian,ZHANG Guofu,FENG Lei. Rational Application of Antidepressants in Pregnancy　[J]. Chinese General Practice, 2019, 22(24): 2955-2961. DOI: 10.12114/j.issn.1007-9572.2019.00.182.
翟倩,张国富,丰雷. 妊娠期抗抑郁药物的合理应用[J]. 中国全科医学, 2019, 22(24): 2955-2961. DOI: 10.12114/j.issn.1007-9572.2019.00.182.

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[3]	CHEN Hongxu, WANG Denglan, CHEN Yuanyuan, SHEN Juanjuan, SONG Chun, WANG Fan, KONG Tiantian. The Relationship between Remnant Cholesterol and Maternal Depression and Pregnancy Stress in the Second Trimester [J]. Chinese General Practice, 2025, 28(11): 1347-1353.
[4]	LUO Xiaoxi, CHEN Junyu, JIA Honghong, LIU Li, LI Chunhong, YANG Nana, HAN Guangli, ZHOU Yuqiu. Investigation on the Current Status of Standard Pregnancy Health Care and Self-management Behavior of Rural Women [J]. Chinese General Practice, 2025, 28(08): 989-995.
[5]	FANG Xiang, SONG Haiqi, LIAO Xiaoyang, LIU Lidi, ZHANG Peng, JIA Yu, YANG Ziyu, YANG Rong, LIU Ruhui. Recommendations for the Management of Hypertensive Disorders of Pregnancy in China: Based on the A Summary of the 2023 Society of Obstetric Medicine of Australia and New Zealand Hypertension in Pregnancy Guideline [J]. Chinese General Practice, 2025, 28(06): 649-654.
[6]	WEI Zhanchao, WANG Jia, LIU Cheng, ZHENG Wei, LI Guanghui. Isolated Maternal Hypothyroxinemia in the First Trimester Increases the Risks of Macrosomia and Large for Gestational Age During Pregnancy: a Retrospective Cohort Study [J]. Chinese General Practice, 2024, 27(29): 3595-3601.
[7]	XU Lili, ZHENG Wei, YUAN Xianxian, MA Kaiwen, ZHANG Puyang, LI Guanghui. The Relationship between Body Composition in Early Pregnancy and Gestational Diabetes Mellitus in a Population of Normal BMI Pregnant Women [J]. Chinese General Practice, 2024, 27(29): 3602-3607.
[8]	JIA Jianrui, YAN Xin, ZHANG Lirui, ZHENG Wei, LI Guanghui. The Relationship between Gestational Weight Gain and Pregnancy Outcomes in Patients with Type 2 Diabetes [J]. Chinese General Practice, 2024, 27(29): 3608-3615.
[9]	ZHANG Peng, LIU Lidi, YANG Ziyu, YANG Rong, LYU Yao, ZHOU Yiheng, FANG Xiang, LEI Yi, DAI Hua, LIAO Xiaoyang. Interpretation of the 2023 Recommendation Statement by the U.S. Preventive Services Task Force on the Screening for Hypertensive Disorders of Pregnancy [J]. Chinese General Practice, 2024, 27(29): 3581-3586.
[10]	YANG Xinhui, PENG Xiaoxiao, MA Lili, ZHAO Guoyu, MA Xiuhua, GUO Jing. Title Vaginal Microbiota Changes of Gestational Diabetes Mellitus Pregnant Women at Different Gestational Weeks and the Impact on Pregnancy Outcome: a Prospective Cohort Study [J]. Chinese General Practice, 2024, 27(29): 3587-3594.
[11]	ZHOU Jun, LIU Xiaoyu, WANG Ping, YAN Yan, LIN Jiaming, ZHANG Kuayue, DONG Pengxuan, LIU Yuzhi, HU Xiaocong, MI Baohong, WANG Rongtian, CHEN Yuefeng, CHEN Weiheng. The Current Status of Non-surgical Treatment for Knee Osteoarthritis Patients in the Community: a Multi-center Cross-sectional Study [J]. Chinese General Practice, 2024, 27(24): 2969-2975.
[12]	Eating Disorders Coordination Group of the Psychosomatic Medicine Society of the Chinese Medical Association, Eating Disorders Research Collaboration Group of the Psychiatric Medicine Society of the Chinese Medical Association, PENG Sufang, HE Qianqian, LIU Qiang, CHEN Yan, ZHANG Lan, LI Xueni, QIAO Huifen, KONG Qingmei, KUANG Guifang, CHEN Han, YU Yang, JIANG Jingjing, LIU Lanying, ZHANG Darong, LI Keqing, WANG Zhen, CHEN Jue. Chinese Expert Consensus on the Diagnosis and Treatment of Binge Eating Disorder [J]. Chinese General Practice, 2024, 27(24): 2941-2953.
[13]	DONG Yumeng, LIU Jinghua. Fetal Outcomes of Double Chorion Double Amniotic Sac Twin Pregnancy by Ultrasonographic Soft Marker Combined with Twin Specific Marker in Early Pregnancy [J]. Chinese General Practice, 2024, 27(12): 1460-1467.
[14]	WANG Chao, HOU Zheng, LI Huajun, LI Rong, QIAO Jie. Clinical Characteristics and Management of Different Types of Cesarean Scar Pregnancy [J]. Chinese General Practice, 2024, 27(12): 1475-1479.
[15]	XU Jun, QI Wenjie, WANG Chao, HU Lan, MIAO Bin. Analysis of Clinical Characteristics and Maternal and Neonatal Outcomes in Pregnancy Complicated with Acute Pancreatitis Patients of Different Etiologies [J]. Chinese General Practice, 2024, 27(11): 1343-1348.