Cryptococcal Pulmonary and Skin Infections Secondary to Immunosuppressive Agent Treatment for Nephrotic Syndrome：a Case Report and Literature Review

doi:10.12114/j.issn.1007-9572.2018.00.354

Abstract

Abstract: Invasive fungal infections are common in immunocompromised hosts with difficult diagnosis and high fatality.Nephrotic syndrome patients receiving immunosuppressive agent treatment are probably susceptible to invasive fungal infections due to decreased immune functions caused by the treatment.Cryptococcal infections is a global fungal disease caused by cryptococcus whose incidence rate is rising in recent years.However，nephrotic syndrome with cryptococcal infections is relatively rare，in particular，cryptococcus spreads to the skin via the bloodstream is more rare，which is often misdiagnosed.In this paper，we reported a case of nephrotic syndrome with cryptococcal pulmonary and skin infections following immunosuppressive agent treatment on the basis of reviewing adequate studies pertinent to the case.

Key words: Nephrotic syndrome, Immunosuppressive agents, Cryptococcus, Case reports, Historical article

摘要： 侵袭性真菌感染常见于免疫功能受损的免疫宿主，确诊困难，病死率高，肾病综合征患者应用免疫抑制剂治疗可导致其成为侵袭性真菌感染的免疫宿主。隐球菌感染是由隐球菌引起的一种全球性的真菌病，发病率呈上升趋势，但肾病综合征隐球菌感染相对少见，特别是经血液播散至皮肤更少见，误诊率高。本文报道1例肾病综合征患者应用免疫抑制剂治疗并发肺及皮肤隐球菌感染的病例，并结合国内外相关文献进行分析。

关键词: 肾病综合征, 免疫抑制剂, 隐球菌, 病例报告, 历史文献

FENG Zhen,DONG Chunxia,GUO Lan, et al. Cryptococcal Pulmonary and Skin Infections Secondary to Immunosuppressive Agent Treatment for Nephrotic Syndrome：a Case Report and Literature Review　[J]. Chinese General Practice, 2019, 22(17): 2130-2135. DOI: 10.12114/j.issn.1007-9572.2018.00.354.
冯珍,董春霞,郭岚等. 肾病综合征应用免疫抑制剂治疗并发肺及皮肤隐球菌感染一例报道并文献复习[J]. 中国全科医学, 2019, 22(17): 2130-2135. DOI: 10.12114/j.issn.1007-9572.2018.00.354.

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