Abstract: Background　Cancer-related fatigue （CRF） is one of the most common uncomfortable symptoms experienced by cancer patients during and after chemotherapy， which seriously affects their quality of life and treatment progress. At present， its pathophysiological mechanism is not clear， and there is a lack of widely recognized and effective interventions.Objective　To observe the clinical efficacy of Jianpi Shengsui Herbal Paste for post-chemotherapy cancer-related fatigue.Methods　In the tumor outpatient or impatient department of First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from July 2015 to July 2016，a total of 80 patients with post-chemotherapy cancer-related fatigue who met the research criteria were selected and divided into two groups in the principle of voluntariness，with 38 cases in the treatment group and 42 patients in the control group.Patients in the treatment group received chemotherapy and Jianpi Shengsui Herbal Paste，which was given 3 times/day and 20 g/time，with 21 days as a course and totally 2 courses.Patients in the control group received chemotherapy only，with 21 days as a course，and totally 2 courses.The Fatigue Scale（FS-14） scores（physical fatigue score，mental fatigue score，FS-14 total score），anemia condition and marrow function indexes（hemoglobin level and neutrophil count） were observed and compared during the process.Results　There was a positive correlation between FS-14 total score and anemia（rs=0.882，P<0.001）．For patients with mild anemia in the two groups，the differences of their physical fatigue score，mental fatigue score and FS-14 total score before and after treatment showed no statistical significance（P>0.05）；for patients with mild anemia in the control group，the differences of their physical fatigue score，mental fatigue score and FS-14 total score before and after treatment showed no statistical significance（P>0.05）；and for patients with mild anemia in the treatment group，the differences of their physical fatigue score and FS-14 total score before and after treatment were not statistically significant（P>0.05），but the difference of their mental fatigue score before and after treatment was statistically significant（P<0.05）．For patients with moderate anemia，there was no significant differences in physical fatigue score，mental fatigue score and FS-14 total score between the two groups before treatment （P>0.05）；after treatment，the difference of physical fatigue score in these patients in the two groups showed statistical significance（P<0.05），but the differences of their mental fatigue score and FS-14 total score still had no statistical significance（P>0.05）．In the control group，the difference of physical fatigue scores before and after treatment in patients with moderate anemia was statistically significant（P<0.05）；and the differences of mental fatigue score and FS-14 total score before and after treatment showed no statistical significance（P>0.05）；in the treatment group，the differences of physical fatigue score and FS-14 total score before and after treatment in patients with moderate anemia showed statistical significance（P<0.05），but the differences of the mental fatigue score had no statistical significance（P>0.05）．For the hemoglobin level and neutrophil count of the two groups，their differences before and after treatment showed no statistical significance（P>0.05）．There was no significant difference in neutrophil count and hemoglobin level between the two groups after treatment（P>0.05）．The difference of hemoglobin in treatment group before and after treatment was significant（P<0.05）．Conclusion　Jianpi Shengsui Herbal Paste can alleviate the post-chemotherapy cancer-related fatigue，and improve anemia outcome and the survival quality of patients.

Key words: Fatigue, Herbal paste, Cancer-related fatigue, Chemoradiotherapy, Treatment outcome

摘要： 背景　癌因性疲乏（CRF）是肿瘤患者进行化疗过程中及化疗后最常见的不适症状之一，严重影响患者的生活质量、治疗进度。目前，其病理生理学机制尚不明确，也缺少广泛认可和有效的干预手段。目的　观察健脾生髓膏方治疗化疗后CRF的临床疗效。方法　选取2015年7月—2016年7月广州中医药大学第一附属医院肿瘤门诊或住院部符合研究标准的80例化疗后癌症患者，按照自愿原则将患者分为治疗组38例，对照组42例。治疗组给予化疗+健脾生髓膏方治疗，健脾生髓膏方3次/d，20 g/次，21 d为1个疗程；对照组给予化疗。观察并比较两组疲劳量表（FS-14）评分（包括躯体疲劳、脑力疲劳）、贫血情况、骨髓功能指标（血红蛋白水平和中性粒细胞计数）。结果　FS-14总分与贫血情况呈正相关（rs=0.882，P<0.001）。两组轻度贫血患者治疗前、后躯体疲劳评分、脑力疲劳评分、FS-14总分比较，差异无统计学意义（P>0.05）；对照组轻度贫血患者躯体疲劳评分、脑力疲劳评分、FS-14总分组内治疗前后比较，差异无统计学意义（P>0.05）；治疗组轻度贫血患者躯体疲劳评分、FS-14总分组内治疗前后比较，差异无统计学意义（P>0.05）；治疗组轻度贫血患者脑力疲劳评分组内治疗前后比较，差异有统计学意义（P<0.05）。治疗前两组中度贫血患者躯体疲劳评分、脑力疲劳评分、FS-14总分比较，差异无统计学意义（P>0.05）；治疗后两组中度贫血患者躯体疲劳评分比较，差异有统计学意义（P<0.05）；治疗后两组中度贫血患者脑力疲劳评分、FS-14总分比较，差异无统计学意义（P>0.05）。对照组中度贫血患者躯体疲劳评分组内治疗前后比较，差异有统计学意义（P<0.05）；对照组中度贫血患者脑力疲劳评分、FS-14总分组内治疗前后比较，差异无统计学意义（P>0.05）；治疗组中度贫血患者躯体疲劳评分、FS-14总分组内治疗前后比较，差异有统计学意义（P<0.05）；治疗组中度贫血患者脑力疲劳评分组内治疗前后比较，差异无统计学意义（P>0.05）。两组治疗前、后血红白蛋水平与中性粒细胞计数比较，差异无统计学意义（P>0.05）。两组血红蛋白水平、中性粒细胞计数组内治疗前后比较，差异无统计学意义（P>0.05）。治疗组血红蛋白水平组内治疗前后比较，差异有统计学意义（P<0.05）。结论　健脾生髓膏方能缓解化疗后CRF，改善贫血，提高患者生存质量。

关键词: 疲劳, 膏剂, 癌因性疲乏, 化放疗, 治疗结果