Abstract: Background　Cancer-related fatigue（CRF），as a common，multidimensional，and subjective sense of tiredness related to cancer，severely affects the quality of life. Compared to standard chemotherapy，cord blood stem cell transplantation is a more intensive treatment that its side effects of chemotherapy，infection and graft-versus-host disease can easily appear，and can increase the risk of fatigue. Objective　To investigate the status and correlation of CRF and quality of life in children with umbilical cord blood stem cell transplantation from different ages.Methods　A total of 32 cases with umbilical cord blood stem cell transplantation admitted to Department of Hematology ，the First Affiliated Hospital of University of Science and Technology of China from November 2016 to January 2018 were selected by convenience sampling method.Patients were divided into children group （age of 8 to 12 years，15 cases） and adolescent group （age of 13 to 17 years，17 cases）.Pediatric Quality of Life Inventory Multidimensional Fatigue Scale （PedsQLTM MFS） and PedsQLTM3.0 Cancer Module were used to evaluate the fatigue level and quality of life 1 to 3 days before discharge.Results　There were no significant differences in general fatigue，cognitive fatigue and PedsQLTM MFS total score between children group and adolescent group （P>0.05）.Rest fatigue score of children group was higher than that of adolescent group （P<0.05）.No significant differences were found in pain，nausea and vomiting，procedure anxiety，treatment anxiety，worry，cognition，appearance，communication and PedsQLTM3.0 Cancer Module total score （P>0.05）.The total score of PedsQLTM MFS was positively correlated with PedsQLTM3.0 Cancer Module （r=0.620，P<0.001）.The score of general fatigue was associated with scores of nausea and vomiting，procedure anxiety，treatment anxiety，worry and cognition positively in all subjects （P<0.05）.The score of rest fatigue was positively related with scores of pain，nausea and vomiting，procedure anxiety，treatment anxiety，worry and cognition （P<0.05）.The score of cognitive fatigue was positively related with scores of procedure anxiety，treatment anxiety，worry，cognition，appearance and communication （P<0.05）.Conclusion　Patients with umbilical cord blood stem cell transplantation suffered heavy CRF，especially in adolescent group.They have poor quality of life，positively associated with fatigue.

Key words: Cord blood stem cell transplantation, Fatigue, Cancer related fatigue, Quality of life, Child

摘要： 背景　癌因性疲乏（CRF）作为一种与肿瘤相关的、常见的、多维的、主观的症状，严重影响患者的生命质量。脐血干细胞移植是一种比标准化疗更强化的治疗，患者极易发生化疗毒副作用、感染、移植物抗宿主病等，增加疲乏发生的风险。目的　调查不同年龄脐血干细胞移植患儿CRF与生活质量的现状，并分析其相关性。方法　采用便利抽样方法选取2016年11月—2018年1月中国科学技术大学附属第一医院血液科住院的32例脐血干细胞移植患儿，按照年龄将其分为儿童组（8~12岁，15例）、青少年组（13~17岁，17例）。于患儿出院前1~3 d，采用中文版儿童多维疲乏量表（PedsQLTM MFS）评价患儿住院期间的疲乏水平，采用中文版儿童生存质量量表（PedsQLTM）3.0癌症模块评价患儿住院期间的生活质量。结果　儿童组与青少年组一般疲乏、认知疲乏得分及PedsQLTM MFS总分比较，差异均无统计学意义（P>0.05）；儿童组休息疲乏得分高于青少年组（P<0.05）。儿童组与青少年组疼痛、恶心呕吐、操作焦虑、治疗焦虑、担忧、认知、外貌、交流得分及PedsQLTM3.0癌症模块总分比较，差异均无统计学意义（P>0.05）。所有患儿的PedsQLTM MFS总分与PedsQLTM3.0癌症模块总分呈正相关（r=0.620，P<0.001）。所有患儿的一般疲乏得分与恶心呕吐、操作焦虑、治疗焦虑、担忧、认知得分均呈正相关，休息疲乏得分与疼痛、恶心呕吐、操作焦虑、治疗焦虑、担忧、认知得分均呈正相关，认知疲乏得分与操作焦虑、治疗焦虑、担忧、认知、外貌、交流得分均呈正相关（P<0.05）。结论　脐血干细胞移植患儿CRF较重，特别是青少年组患儿的休息疲乏更严重；生活质量水平低，且与疲乏水平呈正相关。

关键词: 脐血干细胞移植, 疲劳, 癌因性疲乏, 生活质量, 儿童