Abstract: Background Fatigue is prevalent in patients with chronic kidney disease（CKD）and closely associated with reduced quality of life and increased mortality. Currently，Patient-Reported Outcome Measures（PROMs）are commonly employed to assess fatigue. However，these measures exhibit variations in format. There is no consensus about how to choose an appropriate one to use in clinical practice. Objective Systematically assess the advantages, disadvantages, and target populations of various scales to provide clinical practitioners with a reference for choosing appropriate assessment tools. Methods A systematic search of database like PubMed, Web of Science, CNKI, VIP, and Wanfang Data was conducted for literatures about fatigue assessment in patients with CKD, from January 2018 to April 2024. The data were independently screened and extracted by two researchers, and by comparing the assessment methods, advantages and disadvantages of each scale to inform the choice of fatigue assessment scales in different CKD populations. Results The study reveals that CKD-related fatigue scales can be categorized into general fatigue scales and specific population fatigue scale. All these scales employ Likert scale for fatigue assessment. We found that health status survey instruments and the Dialysis Symptom Index Scale（DSI）were suitable for screening fatigue symptoms in CKD；the Piper Fatigue Scale-Revised（PFS-R）with multidimensional scale was the most commonly used in clinical practice and a promising scale for the assessment of fatigue in CKD because it could clearly differentiate between the degree and dimensions of fatigue. Conclusion There are many fatigue scales to assess fatigue for patients with CKD. Clinical practitioners should consider the characteristics of the CKD study population comprehensively and choose the appropriate scale for fatigue assessment.

Key words: Nephrology, Chronic Kidney Disease, Fatigue, Patient-Reported Outcome Measures, General Fatigue Scale, Specific Population Fatigue Scale

摘要： 背景 疲乏是慢性肾脏病（CKD）患者最常见的症状，并且与较低的生活质量和较高的死亡风险密切相关。目前常用患者报告结局评估量表（PROM）评估CKD相关疲乏，然而此类量表形式各异，适用人群有所侧重，尚未形成一致的共识，影响临床选择应用。目的 系统评价各量表的优缺点及适用人群，为临床工作者选择合适的评估量表提供参考。方法 系统检索 PubMed、Web of Science、中国知网、维普网、万方数据知识服务平台，筛选与慢性肾脏病疲乏评估的相关文献，检索时间限制为2018年1月—2024年4月，数据由两位研究者独立筛选和提取，通过对比各量表的评估方式、优缺点等，探索分析不同CKD人群疲乏评估量表的选择。结果 CKD 相关疲乏量表主要可分为普适性量表和特殊人群量表，其中所有量表均采用Likert法评估。健康状况调查量表、透析症状指数量表（DSI）适用于CKD疲乏症状的筛查；Piper疲乏修订量表（PFS-R）作为多维度量表，临床应用最广泛，能够明确区分疲乏程度和维度，可能较适合CKD患者的疲乏评估。结论 CKD 相关疲乏量表众多，临床从业者需综合考虑CKD研究人群特点，选择疲乏评估量表。

关键词: 肾脏病学, 慢性肾脏病, 疲乏, 患者报告结局评估量表, 普适性疲乏量表, 特殊人群疲乏量表